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Gene

YWHAZ

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

Summary

Cytogenetic location
8q22.3
Coordinates
Chromosome 8: 100,916,523–100,952,020 (GRCh38)
Exons
6 exons across 35.5 kb
Protein
245 amino acids
Also known as
KCIP-1, 14-3-3-zeta
Previous symbols
YWHAD
MANE Select transcript
ENST00000395958.6NM_145690.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads YWHAZ yet. The test sequences your whole genome, so your data includes it all the same.

How YWHAZ is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 8, with a bracket where YWHAZ sits. YWHAZ and 4 genes near it on chromosome 8, from 100,434,272 to 101,434,271.Chromosome 88q22.3p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.3100.6 Mb100.8 Mb101 Mb101.2 Mb101.4 MbANKRD46: 100,509,752–100,559,789, reverse strandANKRD46SNX31: 100,572,882–100,663,415, reverse strandSNX31PABPC1: 100,685,816–100,722,809, reverse strandPABPC1YWHAZ: 100,916,523–100,952,020, reverse strandYWHAZZNF706: 101,171,214–101,207,085, reverse strandZNF706Diagram of YWHAZ: 6 exons on the reverse strand of chromosome 8Exon 3: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 6: 100,916,523–100,920,752, 4,230 basesExon 5: 100,923,955–100,924,050, 96 basesExon 4: 100,924,135–100,924,298, 164 basesExon 3: 100,924,916–100,925,039, 124 basesExon 2: 100,948,596–100,948,900, 305 basesExon 1: 100,951,929–100,952,020, 92 bases64215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5 kb of the gene's 35.5 kb; 738 of those bases code for the protein.

How a genome test reads YWHAZ

2

positions in YWHAZ where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (50%) falls in a region short reads find hard.

  • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.

A whole genome covers all 35.5 kb of YWHAZ, introns included, not only the 5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). YWHAZ gene: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta. Retrieved 17 October 2026, from https://dantelabs.com/genes/ywhaz

Vancouver

Dante Labs. YWHAZ gene: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ywhaz

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