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Gene

PPP2R1A

protein phosphatase 2 scaffold subunit Aalpha

Summary

Cytogenetic location
19q13.41
Coordinates
Chromosome 19: 52,190,052–52,229,518 (GRCh38)
Exons
15 exons across 39.5 kb
Protein
589 amino acids
Also known as
PR65A, PP2A-Aalpha, PP2AA
MANE Select transcript
ENST00000322088.11NM_014225.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PPP2R1A yet. The test sequences your whole genome, so your data includes it all the same.

How PPP2R1A is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where PPP2R1A sits. PPP2R1A and 27 genes near it on chromosome 19, from 51,709,785 to 52,709,784.Chromosome 1919q13.41p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4351.8 Mb52 Mb52.2 Mb52.4 Mb52.6 MbSPACA6: 51,688,346–51,712,387, forward strandSPACA6HAS1: 51,713,106–51,723,992, reverse strandHAS1FPR1: 51,742,725–51,804,115, reverse strandFPR1FPR2: 51,752,026–51,771,307, forward strandFPR2FPR3: 51,795,131–51,827,761, forward strandFPR3ZNF577: 51,804,816–51,890,950, reverse strandZNF577ZNF649: 51,888,539–51,905,057, reverse strandZNF649ZNF613: 51,927,147–51,948,759, forward strandZNF613ZNF350: 51,963,979–51,986,860, reverse strandZNF350ZNF615: 51,991,332–52,008,237, reverse strandZNF615ZNF614: 52,012,765–52,030,240, reverse strandZNF614ZNF432: 52,031,378–52,095,773, reverse strandZNF432ZNF841: 52,058,490–52,095,773, reverse strandZNF841ZNF616: 52,112,053–52,139,965, reverse strandZNF616ZNF836: 52,153,864–52,171,678, reverse strandZNF836PPP2R1A: 52,190,052–52,229,518, forward strandPPP2R1AZNF766: 52,269,559–52,296,046, forward strandZNF766ZNF480: 52,297,146–52,325,926, forward strandZNF480ZNF610: 52,336,238–52,367,835, forward strandZNF610ZNF880: 52,369,914–52,393,738, forward strandZNF880ZNF528: 52,397,842–52,418,412, forward strandZNF528ZNF534: 52,429,143–52,452,315, forward strandZNF534ZNF578: 52,453,551–52,516,882, forward strandZNF578ZNF808: 52,527,623–52,564,464, forward strandZNF808ZNF701: 52,555,822–52,599,928, forward strandZNF701: 52,592,755–52,690,606, reverse strandZNF83: 52,612,356–52,638,388, reverse strandZNF83ZNF611: 52,701,842–52,735,102, reverse strandZNF611Diagram of PPP2R1A: 15 exons on the forward strand of chromosome 19Exon 4: 2 known disease-causing sitesExon 5: 10 known disease-causing sitesExon 6: 3 known disease-causing sitesExon 7: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 1: 52,190,052–52,190,174, 123 basesExon 2: 52,201,944–52,202,034, 91 basesExon 3: 52,205,963–52,206,063, 101 basesExon 4: 52,211,260–52,211,492, 233 basesExon 5: 52,212,686–52,212,833, 148 basesExon 6: 52,212,955–52,213,110, 156 basesExon 7: 52,215,779–52,215,893, 115 basesExon 8: 52,216,004–52,216,074, 71 basesExon 9: 52,216,529–52,216,663, 135 basesExon 10: 52,219,691–52,219,864, 174 basesExon 11: 52,220,189–52,220,249, 61 basesExon 12: 52,220,979–52,221,133, 155 basesExon 13: 52,222,099–52,222,241, 143 basesExon 14: 52,225,717–52,225,808, 92 basesExon 15: 52,225,965–52,229,518, 3,554 bases12468101214155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.4 kb of the gene's 39.5 kb; 1,770 of those bases code for the protein.

How a genome test reads PPP2R1A

18

positions in PPP2R1A where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 39.5 kb of PPP2R1A, introns included, not only the 5.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PPP2R1A gene: protein phosphatase 2 scaffold subunit Aalpha. Retrieved 16 October 2026, from https://dantelabs.com/genes/ppp2r1a

Vancouver

Dante Labs. PPP2R1A gene: protein phosphatase 2 scaffold subunit Aalpha [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ppp2r1a

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