Skip to content
Use your HSA or FSA funds

Gene

DMPK

DM1 protein kinase

Summary

Cytogenetic location
19q13.32
Coordinates
Chromosome 19: 45,769,717–45,782,490 (GRCh38)
Exons
15 exons across 12.8 kb
Protein
629 amino acids
Inheritance
Autosomal dominant
Also known as
DMK, DM1PK, MDPK, MT-PK
Previous symbols
DM1, DM
MANE Select transcript
ENST00000291270.9NM_004409.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Myotonic Dystrophy

    • Autosomal dominant

      An inherited progressive disorder affecting the muscles. It is characterized by muscle wasting and hypotonia, cataracts, heart conduction defects and endocrinopathies.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Mexiletine for myotonia; cardiac pacemaker/ICD for conduction disease; non-invasive ventilation for respiratory insufficiency; annual cardiac and pulmonary monitoring; avoidance of certain anesthetic agents

Broader groupings

  • Hypertrophic Cardiomyopathy

    • Autosomal dominant

      One of 62 genes linked to it

      A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Beta-blockers, non-dihydropyridine calcium channel blockers, activity restriction, genetic counseling

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How DMPK is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where DMPK sits. DMPK and 35 genes near it on chromosome 19, from 45,276,104 to 46,276,103.Chromosome 1919q13.32p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4345.4 Mb45.6 Mb45.8 Mb46 Mb46.2 MbMARK4: 45,079,288–45,305,284, forward strandMARK4CKM: 45,306,411–45,323,372, reverse strandCKMKLC3: 45,333,434–45,351,537, forward strandKLC3ERCC2: 45,349,773–45,370,918, reverse strandERCC2PPP1R13L: 45,379,634–45,406,367, reverse strandPPP1R13LPOLR1G: 45,406,644–45,410,737, forward strandPOLR1GERCC1: 45,407,333–45,479,055, reverse strandERCC1FOSB: 45,467,989–45,475,179, forward strandFOSBRTN2: 45,485,292–45,497,055, reverse strandRTN2PPM1N: 45,488,777–45,503,129, forward strandPPM1NVASP: 45,506,579–45,527,839, forward strandVASPOPA3: 45,527,767–45,602,212, reverse strandOPA3GPR4: 45,588,565–45,602,556, reverse strandGPR4EML2: 45,606,994–45,645,617, reverse strandEML2GIPR: 45,668,207–45,683,722, forward strandGIPRSNRPD2: 45,677,907–45,692,569, reverse strandSNRPD2QPCTL: 45,692,403–45,703,989, forward strandQPCTLFBXO46: 45,710,624–45,730,931, reverse strandFBXO46MEIOSIN: 45,733,439–45,764,541, forward strandSIX5: 45,764,767–45,769,252, reverse strandSIX5DMPK: 45,769,717–45,782,490, reverse strandDMPK: 45,779,437–45,785,973, reverse strandDMWD: 45,782,944–45,792,949, reverse strandDMWDRSPH6A: 45,795,713–45,815,308, reverse strandSYMPK: 45,815,410–45,866,862, reverse strandSYMPKFOXA3: 45,863,989–45,873,798, forward strandFOXA3IRF2BP1: 45,883,608–45,886,141, reverse strandIRF2BP1MYPOP: 45,890,020–45,902,808, reverse strandMYPOPNANOS2: 45,913,214–45,914,778, reverse strandNANOS2NOVA2: 45,933,734–45,974,044, reverse strandNOVA2CCDC61: 45,995,444–46,021,318, forward strandCCDC61PGLYRP1: 46,019,153–46,023,367, reverse strandPGLYRP1IGFL4: 46,039,182–46,077,118, reverse strandIGFL4IGFL2: 46,079,126–46,161,298, forward strandIGFL2IGFL3: 46,120,067–46,124,698, reverse strandIGFL3IGFL1: 46,229,732–46,231,243, forward strandIGFL1Diagram of DMPK: 15 exons on the reverse strand of chromosome 19Exon 15: 1 known disease-causing siteExon 15: 45,769,717–45,770,640, 924 basesExon 14: 45,770,971–45,771,060, 90 basesExon 13: 45,771,350–45,771,396, 47 basesExon 12: 45,771,568–45,771,665, 98 basesExon 11: 45,771,771–45,771,928, 158 basesExon 10: 45,772,641–45,772,752, 112 basesExon 9: 45,774,949–45,775,034, 86 basesExon 8: 45,777,327–45,777,590, 264 basesExon 7: 45,777,667–45,777,873, 207 basesExon 6: 45,778,127–45,778,220, 94 basesExon 5: 45,778,493–45,778,641, 149 basesExon 4: 45,779,264–45,779,359, 96 basesExon 3: 45,779,439–45,779,522, 84 basesExon 2: 45,779,778–45,779,869, 92 basesExon 1: 45,782,193–45,782,490, 298 bases15141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.8 kb of the gene's 12.8 kb; 1,890 of those bases code for the protein.

How a genome test reads DMPK

1

position in DMPK where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 12.8 kb of DMPK, introns included, not only the 2.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DMPK gene: DM1 protein kinase. Retrieved 16 October 2026, from https://dantelabs.com/genes/dmpk

Vancouver

Dante Labs. DMPK gene: DM1 protein kinase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dmpk

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test