Trait
Liver failure
Clinical name: Hepatic failure
Summary
- Also called
- Hepatic insufficiency
- Body system
- Abnormality of the digestive system
Reference genomeGRCh38hg38
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Get my Genome Test141 genes linked to Liver failure
Changes in these genes cause rare conditions in which Liver failure is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCD3ATP binding cassette subfamily D member 3 | Always | In 1 condition |
| APOA1apolipoprotein A1 | Always | In 1 condition |
| ATP7BATPase copper transporting beta | Always | In 1 condition |
| CYP7B1cytochrome P450 family 7 subfamily B member 1 | Always | In 2 conditions |
| DCDC2doublecortin domain containing 2 | Always | In 1 condition |
| DGUOKdeoxyguanosine kinase | Always | In 1 condition |
| F8coagulation factor VIII | Always | In 1 condition |
| FAHfumarylacetoacetate hydrolase | Always | In 1 condition |
| FHfumarate hydratase | Always | In 1 condition |
| IL18BPinterleukin 18 binding protein | Always | In 1 condition |
| IL27RAinterleukin 27 receptor subunit alpha | Always | In 1 condition |
| LIPAlipase A, lysosomal acid type | Always | In 3 conditions |
| MARS1methionyl-tRNA synthetase 1 | Always | In 1 condition |
| MRM2mitochondrial rRNA methyltransferase 2 | Always | In 1 condition |
| NR1H4nuclear receptor subfamily 1 group H member 4 | Always | In 1 condition |
| PCK1phosphoenolpyruvate carboxykinase 1 | Always | In 1 condition |
| PEX19peroxisomal biogenesis factor 19 | Always | In 2 conditions |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Always | In 2 conditions |
| POT1protection of telomeres 1 | Always | In 1 condition |
| PSKH1protein serine kinase H1 | Always | In 1 condition |
| RFC4replication factor C subunit 4 | Always | In 1 condition |
| TFAMtranscription factor A, mitochondrial | Always | In 1 condition |
| UBR1ubiquitin protein ligase E3 component n-recognin 1 | Always | In 1 condition |
| CPT1Acarnitine palmitoyltransferase 1A | Very often (80–99%) | In 1 condition |
| OTCornithine transcarbamylase | Very often (80–99%) | In 1 condition |
| PEX1peroxisomal biogenesis factor 1 | Very often (80–99%) | In 1 condition |
| PEX10peroxisomal biogenesis factor 10 | Very often (80–99%) | In 1 condition |
| PEX11Bperoxisomal biogenesis factor 11 beta | Very often (80–99%) | In 1 condition |
| PEX12peroxisomal biogenesis factor 12 | Very often (80–99%) | In 1 condition |
| PEX13peroxisomal biogenesis factor 13 | Very often (80–99%) | In 1 condition |
| PEX14peroxisomal biogenesis factor 14 | Very often (80–99%) | In 1 condition |
| PEX16peroxisomal biogenesis factor 16 | Very often (80–99%) | In 1 condition |
| PEX2peroxisomal biogenesis factor 2 | Very often (80–99%) | In 1 condition |
| PEX26peroxisomal biogenesis factor 26 | Very often (80–99%) | In 1 condition |
| PEX3peroxisomal biogenesis factor 3 | Very often (80–99%) | In 1 condition |
| PEX5peroxisomal biogenesis factor 5 | Very often (80–99%) | In 1 condition |
| PEX6peroxisomal biogenesis factor 6 | Very often (80–99%) | In 1 condition |
| SMPD1sphingomyelin phosphodiesterase 1 | Very often (80–99%) | In 2 conditions |
| ACTG2actin gamma 2, smooth muscle | Often (30–79%) | In 1 condition |
| AKR1D1aldo-keto reductase family 1 member D1 | Often (30–79%) | In 2 conditions |
Show 101 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| COX16cytochrome c oxidase assembly factor COX16 | Often (30–79%) | In 1 condition |
| CPT2carnitine palmitoyltransferase 2 | Often (30–79%) | In 2 conditions |
| DEF6DEF6 guanine nucleotide exchange factor | Often (30–79%) | In 1 condition |
| FOCADfocadhesin | Often (30–79%) | In 1 condition |
| GALTgalactose-1-phosphate uridylyltransferase | Often (30–79%) | In 1 condition |
| GFM1G elongation factor mitochondrial 1 | Often (30–79%) | In 1 condition |
| H4C3H4 clustered histone 3 | Often (30–79%) | In 1 condition |
| IL12Ainterleukin 12A | Often (30–79%) | In 1 condition |
| IL12RB1interleukin 12 receptor subunit beta 1 | Often (30–79%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Often (30–79%) | In 1 condition |
| MMEL1membrane metalloendopeptidase like 1 | Often (30–79%) | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Often (30–79%) | In 1 condition |
| MRPS7mitochondrial ribosomal protein S7 | Often (30–79%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 1 condition |
| POU2AF1POU class 2 homeobox associating factor 1 | Often (30–79%) | In 1 condition |
| RBM10RNA binding motif protein 10 | Often (30–79%) | In 1 condition |
| SC5Dsterol-C5-desaturase | Often (30–79%) | In 1 condition |
| SERAC1serine active site containing 1 | Often (30–79%) | In 1 condition |
| SLC7A7solute carrier family 7 member 7 | Often (30–79%) | In 1 condition |
| SPIBSpi-B transcription factor | Often (30–79%) | In 1 condition |
| TJP2tight junction protein 2 | Often (30–79%) | In 1 condition |
| TNFSF15TNF superfamily member 15 | Often (30–79%) | In 1 condition |
| TNPO3transportin 3 | Often (30–79%) | In 1 condition |
| VMA22vacuolar ATPase assembly factor VMA22 | Often (30–79%) | In 1 condition |
| ACDACD shelterin complex subunit and telomerase recruitment factor | Sometimes (5–29%) | In 1 condition |
| ACVRL1activin A receptor like type 1 | Sometimes (5–29%) | In 1 condition |
| ALMS1ALMS1 centrosome and basal body associated protein | Sometimes (5–29%) | In 1 condition |
| ASLargininosuccinate lyase | Sometimes (5–29%) | In 1 condition |
| BAATbile acid-CoA:amino acid N-acyltransferase | Sometimes (5–29%) | In 1 condition |
| BTNL2butyrophilin like 2 | Sometimes (5–29%) | In 1 condition |
| CILK1ciliogenesis associated kinase 1 | Sometimes (5–29%) | In 1 condition |
| CLDN1claudin 1 | Sometimes (5–29%) | In 1 condition |
| COG4component of oligomeric golgi complex 4 | Sometimes (5–29%) | In 1 condition |
| CTC1CST telomere replication complex component 1 | Sometimes (5–29%) | In 1 condition |
| DKC1dyskerin pseudouridine synthase 1 | Sometimes (5–29%) | In 1 condition |
| DLDdihydrolipoamide dehydrogenase | Sometimes (5–29%) | In 1 condition |
| ENGendoglin | Sometimes (5–29%) | In 1 condition |
| EPM2AEPM2A glucan phosphatase, laforin | Sometimes (5–29%) | In 2 conditions |
| GDF2growth differentiation factor 2 | Sometimes (5–29%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Sometimes (5–29%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 2 conditions |
| IARS1isoleucyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Sometimes (5–29%) | In 1 condition |
| IL21Rinterleukin 21 receptor | Sometimes (5–29%) | In 1 condition |
| JAG1jagged canonical Notch ligand 1 | Sometimes (5–29%) | In 1 condition |
| MED12mediator complex subunit 12 | Sometimes (5–29%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Sometimes (5–29%) | In 1 condition |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Sometimes (5–29%) | In 1 condition |
| MT-ND2mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 | Sometimes (5–29%) | In 1 condition |
| MT-ND3mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 | Sometimes (5–29%) | In 1 condition |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Sometimes (5–29%) | In 1 condition |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Sometimes (5–29%) | In 1 condition |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Sometimes (5–29%) | In 1 condition |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Sometimes (5–29%) | In 1 condition |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Sometimes (5–29%) | In 1 condition |
| MT-TVmitochondrially encoded tRNA-Val (GUN) | Sometimes (5–29%) | In 1 condition |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Sometimes (5–29%) | In 1 condition |
| NHLRC1NHL repeat containing E3 ubiquitin protein ligase 1 | Sometimes (5–29%) | In 1 condition |
| NHP2NHP2 ribonucleoprotein | Sometimes (5–29%) | In 1 condition |
| NOP10NOP10 ribonucleoprotein | Sometimes (5–29%) | In 1 condition |
| NPM1nucleophosmin 1 | Sometimes (5–29%) | In 1 condition |
| P4HA2prolyl 4-hydroxylase subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Sometimes (5–29%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Sometimes (5–29%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Sometimes (5–29%) | In 1 condition |
| SH2D1ASH2 domain containing 1A | Sometimes (5–29%) | In 1 condition |
| SLC25A20solute carrier family 25 member 20 | Sometimes (5–29%) | In 1 condition |
| SLC2A2solute carrier family 2 member 2 | Sometimes (5–29%) | In 1 condition |
| SMAD4SMAD family member 4 | Sometimes (5–29%) | In 1 condition |
| TERCtelomerase RNA component | Sometimes (5–29%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Sometimes (5–29%) | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Sometimes (5–29%) | In 1 condition |
| TYMSthymidylate synthetase | Sometimes (5–29%) | In 1 condition |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Sometimes (5–29%) | In 1 condition |
| WRAP53WD repeat containing antisense to TP53 | Sometimes (5–29%) | In 1 condition |
| XIAPX-linked inhibitor of apoptosis | Sometimes (5–29%) | In 2 conditions |
| ASAH1N-acylsphingosine amidohydrolase 1 | Rarely (1–4%) | In 1 condition |
| ATRXATRX chromatin remodeler | Rarely (1–4%) | In 1 condition |
| F13A1coagulation factor XIII A chain | Rarely (1–4%) | In 1 condition |
| F13Bcoagulation factor XIII B chain | Rarely (1–4%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Rarely (1–4%) | In 2 conditions |
| MAP2K1mitogen-activated protein kinase kinase 1 | Rarely (1–4%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Rarely (1–4%) | In 1 condition |
| RYR1ryanodine receptor 1 | Rarely (1–4%) | In 1 condition |
| SCARB2scavenger receptor class B member 2 | Rarely (1–4%) | In 1 condition |
| SLC25A15solute carrier family 25 member 15 | Rarely (1–4%) | In 1 condition |
| ACAD9acyl-CoA dehydrogenase family member 9 | Not recorded | In 1 condition |
| AMACRalpha-methylacyl-CoA racemase | Not recorded | In 1 condition |
| APTXaprataxin | Not recorded | In 1 condition |
| COQ2coenzyme Q2, polyprenyltransferase | Not recorded | In 1 condition |
| FECHferrochelatase | Not recorded | In 1 condition |
| GBE11,4-alpha-glucan branching enzyme 1 | Not recorded | In 1 condition |
| HSD3B7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | Not recorded | In 1 condition |
| IFT122intraflagellar transport 122 | Not recorded | In 1 condition |
| IFT172intraflagellar transport 172 | Not recorded | In 1 condition |
| MPImannose phosphate isomerase | Not recorded | In 1 condition |
| NDUFS4NADH:ubiquinone oxidoreductase subunit S4 | Not recorded | In 1 condition |
| OSTM1osteoclastogenesis associated transmembrane protein 1 | Not recorded | In 1 condition |
| PCK2phosphoenolpyruvate carboxykinase 2, mitochondrial | Not recorded | In 1 condition |
| SCYL1SCY1 like pseudokinase 1 | Not recorded | In 1 condition |
| SKIC3SKI3 subunit of superkiller complex | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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