Trait
Liver spots
Clinical name: Multiple lentigines
Presence of an unusually high number of lentigines (singular: lentigo), which are flat, tan to brown oval spots.
Summary
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Liver spots, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test17 genes linked to Liver spots
Changes in these genes cause rare conditions in which Liver spots is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Always | In 4 conditions |
| DSTYKdual serine/threonine and tyrosine protein kinase | Always | In 2 conditions |
| GTF2H4general transcription factor IIH subunit 4 | Always | In 1 condition |
| MAP2K2mitogen-activated protein kinase kinase 2 | Always | In 3 conditions |
| NRASNRAS proto-oncogene, GTPase | Always | In 1 condition |
| PTPN11protein tyrosine phosphatase non-receptor type 11 | Always | In 2 conditions |
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Very often (80–99%) | In 3 conditions |
| STK11serine/threonine kinase 11 | Very often (80–99%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Often (30–79%) | In 2 conditions |
| MAP2K1mitogen-activated protein kinase kinase 1 | Often (30–79%) | In 2 conditions |
| PDE11Aphosphodiesterase 11A | Often (30–79%) | In 1 condition |
| PORCNporcupine O-acyltransferase | Often (30–79%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Often (30–79%) | In 2 conditions |
| SMARCAL1SNF2 related chromatin remodeling annealing helicase 1 | Often (30–79%) | In 1 condition |
| MAPK1mitogen-activated protein kinase 1 | Sometimes (5–29%) | In 1 condition |
| SHOC2SHOC2 leucine rich repeat scaffold protein | Sometimes (5–29%) | In 1 condition |
| KITLGKIT ligand | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks