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Trait

High blood monocyte number

Clinical name: Increased total monocyte count

Abnormal increase of absolute number of monocytes in the blood, per microlitre, compared to a reference range for a given sex and age-group.

HPO HP:0012311

Summary

Also called
Monocytosis
Body system
Abnormality of blood and blood-forming tissuesAbnormality of the immune system

18 genes linked to High blood monocyte number

Changes in these genes cause rare conditions in which High blood monocyte number is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ARPC5actin related protein 2/3 complex subunit 5AlwaysIn 1 condition
COPZ1coat protein complex I subunit zeta 1AlwaysIn 1 condition
OTULINOTU deubiquitinase with linear linkage specificityAlwaysIn 1 condition
PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit deltaAlwaysIn 1 condition
SEC61A1SEC61 translocon subunit alpha 1AlwaysIn 1 condition
SRP68signal recognition particle 68AlwaysIn 1 condition
TMEM63Btransmembrane protein 63BAlwaysIn 1 condition
CLPBClpB family mitochondrial disaggregaseOften (30–79%)In 1 condition
ELANEelastase, neutrophil expressedOften (30–79%)In 2 conditions
GFI1growth factor independent 1 transcriptional repressorOften (30–79%)In 2 conditions
IKBKBinhibitor of nuclear factor kappa B kinase subunit betaOften (30–79%)In 1 condition
SRP19signal recognition particle 19Often (30–79%)In 1 condition
TAFAZZINtafazzin, phospholipid-lysophospholipid transacylaseOften (30–79%)In 1 condition
TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3Often (30–79%)In 1 condition
ZNFX1zinc finger NFX1-type containing 1Often (30–79%)In 1 condition
DDX41DEAD-box helicase 41Not recordedIn 1 condition
G6PC3glucose-6-phosphatase catalytic subunit 3Not recordedIn 1 condition
NRASNRAS proto-oncogene, GTPaseNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal monocyte count

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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