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Gene

RRAS2

RAS related 2

Summary

Cytogenetic location
11p15.2
Coordinates
Chromosome 11: 14,277,922–14,359,183 (GRCh38)
Exons
6 exons across 81.3 kb
Protein
204 amino acids
Inheritance
Autosomal dominant
Also known as
TC21
MANE Select transcript
ENST00000256196.9NM_012250.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Noonan Syndrome

    • Autosomal dominant

      Noonan Syndrome (NS) is characterized by short stature, typical facial dysmorphism and congenital heart defects.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Cardiac surveillance, developmental support, growth hormone therapy, genetic counseling, MEK inhibitor trials

    • Noonan Syndrome and Noonan-Related Syndromes

      A group of RAS pathway conditions, including Noonan, Costello, cardiofaciocutaneous and Legius syndromes, with variable heart defects, short stature and distinctive facial features.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing about it supports heart, growth and developmental assessment.

Broader groupings

  • Hypertrophic Cardiomyopathy

    • Autosomal dominant

      One of 62 genes linked to it

      A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Beta-blockers, non-dihydropyridine calcium channel blockers, activity restriction, genetic counseling

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How RRAS2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
  • Variants with a page
Chromosome 11, with a bracket where RRAS2 sits. RRAS2 and 5 genes near it on chromosome 11, from 13,818,553 to 14,818,552.Chromosome 1111p15.2p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2514 Mb14.2 Mb14.4 Mb14.6 Mb14.8 MbSPON1: 13,962,372–14,268,133, forward strandSPON1RRAS2: 14,277,922–14,359,183, reverse strandRRAS2COPB1: 14,443,357–14,500,027, reverse strandCOPB1: 14,493,783–14,520,344, reverse strandPSMA1: 14,504,211–14,643,635, reverse strandPSMA1PDE3B: 14,643,663–14,874,657, forward strandPDE3BDiagram of RRAS2: 6 exons on the reverse strand of chromosome 11Exon 3: 2 known disease-causing sitesExon 1: 5 known disease-causing sitesExon 6: 14,277,922–14,279,424, 1,503 basesExon 5: 14,281,602–14,281,720, 119 basesExon 4: 14,294,471–14,294,579, 109 basesExon 3: 14,294,760–14,294,862, 103 bases. 1 variant with a page in exon 3. List themExon 2: 14,295,768–14,295,855, 88 basesExon 1: 14,358,763–14,359,183, 421 bases64215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.3 kb of the gene's 81.3 kb; 615 of those bases code for the protein.

How a genome test reads RRAS2

7

positions in RRAS2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 81.3 kb of RRAS2, introns included, not only the 2.3 kb of exons.

Variants with a page (1)

The RRAS2 variants with a page here, most review stars first. Each page describes ClinVar's public record of the variant, never a result.

VariantHGVS c.Exon or intronPosition (GRCh38)ClinVar classificationReview status
Q72Lc.215A>TExon 314,294,844Pathogenic3 stars out of 4 reviewed by expert panel

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RRAS2 gene: RAS related 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/rras2

Vancouver

Dante Labs. RRAS2 gene: RAS related 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/rras2

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