Skip to content
Use your HSA or FSA funds

Gene

TSHB

thyroid stimulating hormone subunit beta

Summary

Cytogenetic location
1p13.2
Coordinates
Chromosome 1: 115,029,826–115,034,302 (GRCh38)
Exons
3 exons across 4.5 kb
Protein
138 amino acids
MANE Select transcript
ENST00000256592.3NM_000549.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Congenital Hypothyroidism

    • A thyroid hormone deficiency present from birth.

      • 3 GenCC submitters rate it definitive or strong

  • Thyroid Cancer

    • Hypothyroidism

      Abnormally low levels of thyroid hormone.

      • 3 GenCC submitters rate it definitive or strong
    • Thyroid Gland Disorder

      A disease involving the thyroid gland.

      • 3 GenCC submitters rate it definitive or strong

How TSHB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 1, with a bracket where TSHB sits. TSHB and 9 genes near it on chromosome 1, from 114,532,064 to 115,532,063.Chromosome 11p13.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44114.6 Mb114.8 Mb115 Mb115.2 Mb115.4 MbBCAS2: 114,547,043–114,581,725, reverse strandBCAS2DENND2C: 114,582,848–114,670,451, reverse strandDENND2CAMPD1: 114,673,090–114,695,620, reverse strandAMPD1NRAS: 114,704,468–114,716,775, reverse strandNRASCSDE1: 114,716,913–114,758,704, reverse strandCSDE1SIKE1: 114,769,479–114,780,706, reverse strandSIKE1SYCP1: 114,854,836–114,995,370, forward strandSYCP1TSHB: 115,029,826–115,034,302, forward strandTSHBTSPAN2: 115,047,056–115,089,528, reverse strandTSPAN2NGF: 115,285,904–115,338,770, reverse strandNGFDiagram of TSHB: 3 exons on the forward strand of chromosome 1Exon 2: 2 known disease-causing sitesExon 3: 4 known disease-causing sitesExon 1: 115,029,826–115,029,860, 35 basesExon 2: 115,033,362–115,033,524, 163 basesExon 3: 115,033,973–115,034,302, 330 bases1235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.5 kb of the gene's 4.5 kb; 417 of those bases code for the protein.

How a genome test reads TSHB

8

positions in TSHB where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 4.5 kb of TSHB, introns included, not only the 0.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TSHB gene: thyroid stimulating hormone subunit beta. Retrieved 16 October 2026, from https://dantelabs.com/genes/tshb

Vancouver

Dante Labs. TSHB gene: thyroid stimulating hormone subunit beta [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tshb

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test