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Trait
Abnormality of the sternum
Clinical name: Abnormal sternum morphology
An anomaly of the sternum, also known as the breastbone.
Summary
- Also called
- Sternal anomalies, Pectus carinatum or pectus excavatum, Pectus deformities, Pectus deformity, Pectus excavatum or carinatum, Pectus excavatum or pectus carinatum, Pectus excavatum/carinatum
- Body system
- Abnormality of the musculoskeletal system
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This page as data
Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
url <- "https://dantelabs.com/traits/abnormal-sternum-morphology.json"
page <- fromJSON(url)
page$trait$nameAbnormality of the sternumHP:0000766
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Get my Genome Test42 condition reports read genes linked to this trait
Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.
- Aortic AneurysmReads 12 of these genesTGFB2TGFBR1TGFBR2ACTA2FBN1FOXE3About this report →
- Marfan Like SyndromesReads 8 of these genesBGNTGFB2TGFBR1TGFBR2FBN1SMAD2About this report →
- Loeys-Dietz SyndromeReads 6 of these genesTGFB2TGFBR1TGFBR2SMAD2SMAD3TGFB3About this report →
- Noonan SyndromeReads 10 of these genesSOS1NRASSHOC2BRAFMAP2K1PTPN11About this report →
Show 38 more reports
- Hereditary Gingival FibromatosisReads 2 of these genesSOS1RESTAbout this report →
- Hypertrophic CardiomyopathyReads 10 of these genesSOS1NRASSHOC2BRAFMAP2K1PTPN11About this report →
- Asphyxiating Thoracic Dystrophy 2 (IFT80)Reads 1 of these genesIFT80About this report →
- CHRNG-Related Multiple Pterygium SyndromeReads 1 of these genesCHRNGAbout this report →
- Ferguson-Smith Disease (Multiple Self-Healing Squamous Epithelioma)Reads 1 of these genesTGFBR1About this report →
- IFT140-Related CiliopathyReads 1 of these genesIFT140About this report →
- Jeune Asphyxiating Thoracic Dystrophy (DYNC2H1)Reads 1 of these genesDYNC2H1About this report →
- Short-Rib Thoracic Dysplasia 11 (DYNC2I2)Reads 1 of these genesDYNC2I2About this report →
- Short-Rib Thoracic Dysplasia 8 (DYNC2I1)Reads 1 of these genesDYNC2I1About this report →
- Hereditary Visceral Myopathy, CIPO & MMIHSReads 2 of these genesMYH11MYLKAbout this report →
- Cutis LaxaReads 3 of these genesRIN2EFEMP2ELNAbout this report →
- Hereditary Wilms TumourReads 1 of these genesRESTAbout this report →
- Juvenile Polyposis SyndromeReads 1 of these genesSMAD4About this report →
- Nevoid Basal Cell Carcinoma (Gorlin) SyndromeReads 1 of these genesPTCH1About this report →
- Pseudoxanthoma ElasticumReads 1 of these genesABCC6About this report →
- Hereditary Arterial CalcificationReads 1 of these genesABCC6About this report →
- Hereditary Hemorrhagic TelangiectasiaReads 1 of these genesSMAD4About this report →
- Moyamoya DiseaseReads 1 of these genesACTA2About this report →
- NeurofibromatosisReads 1 of these genesLZTR1About this report →
- Nephronophthisis and Senior-Løken SyndromeReads 2 of these genesTTC21BWDR19About this report →
- Ehlers-Danlos SyndromeReads 2 of these genesCHST14DSEAbout this report →
- Ellis-van Creveld Syndrome and Cranioectodermal DysplasiaReads 1 of these genesWDR19About this report →
- Anterior Segment Dysgenesis, Axenfeld-Rieger Syndrome & AniridiaReads 1 of these genesFOXE3About this report →
- Polycystic Kidney DiseaseReads 1 of these genesIFT140About this report →
- Inherited Congenital Heart DefectsReads 1 of these genesELNAbout this report →
- Retinitis PigmentosaReads 2 of these genesIFT140IFT172About this report →
- Autoimmune DiseaseReads 1 of these genesCHRNGAbout this report →
- Bardet-Biedl and Alström SyndromesReads 1 of these genesIFT172About this report →
- Syndromic CraniosynostosisReads 1 of these genesWDR19About this report →
- Congenital Disorders of GlycosylationReads 2 of these genesCHST14DSEAbout this report →
- Non-Acquired Combined Pituitary Hormone DeficiencyReads 1 of these genesPTCH1About this report →
- Spinal Muscular AtrophyReads 1 of these genesASAH1About this report →
- Inherited ThrombocytopeniasReads 1 of these genesCDC42About this report →
- Joubert Syndrome And Related DisordersReads 1 of these genesCEP120About this report →
- Dilated CardiomyopathyReads 1 of these genesRAF1About this report →
- Intellectual DisabilityReads 2 of these genesMED12SMAD4About this report →
- Lysosomal Storage DiseaseReads 1 of these genesASAH1About this report →
- Inherited Neurodegenerative DisordersReads 1 of these genesASAH1About this report →
Read the genes linked to Abnormality of the sternum, and the rest of your genome, with one test.
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Get my Genome Test57 genes linked to Abnormality of the sternum
Changes in these genes cause rare conditions in which Abnormality of the sternum is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 | Always | In 1 condition |
| CHRNGcholinergic receptor nicotinic gamma subunit | Very often (80–99%) | In 1 condition |
| CHST14carbohydrate sulfotransferase 14 | Very often (80–99%) | In 1 condition |
| DSEdermatan sulfate epimerase | Very often (80–99%) | In 1 condition |
| MYH3myosin heavy chain 3 | Very often (80–99%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Very often (80–99%) | In 1 condition |
| BGNbiglycan | Often (30–79%) | In 1 condition |
| CDC42cell division cycle 42 | Often (30–79%) | In 2 conditions |
| CEP120centrosomal protein 120 | Often (30–79%) | In 1 condition |
| DYNC2H1dynein cytoplasmic 2 heavy chain 1 | Often (30–79%) | In 1 condition |
| DYNC2I1dynein 2 intermediate chain 1 | Often (30–79%) | In 1 condition |
| DYNC2I2dynein 2 intermediate chain 2 | Often (30–79%) | In 1 condition |
| DYNC2LI1dynein cytoplasmic 2 light intermediate chain 1 | Often (30–79%) | In 1 condition |
| IFT140intraflagellar transport 140 | Often (30–79%) | In 1 condition |
| IFT172intraflagellar transport 172 | Often (30–79%) | In 1 condition |
| IFT80intraflagellar transport 80 | Often (30–79%) | In 1 condition |
| KIAA0753KIAA0753 | Often (30–79%) | In 1 condition |
| MED12mediator complex subunit 12 | Often (30–79%) | In 1 condition |
| RESTRE1 silencing transcription factor | Often (30–79%) | In 1 condition |
| RIN2Ras and Rab interactor 2 | Often (30–79%) | In 1 condition |
| RSPRY1ring finger and SPRY domain containing 1 | Often (30–79%) | In 1 condition |
| SHOC2SHOC2 leucine rich repeat scaffold protein | Often (30–79%) | In 1 condition |
| TGFB2transforming growth factor beta 2 | Often (30–79%) | In 2 conditions |
| TGFBR1transforming growth factor beta receptor 1 | Often (30–79%) | In 2 conditions |
| TGFBR2transforming growth factor beta receptor 2 | Often (30–79%) | In 2 conditions |
| TTC21Btetratricopeptide repeat domain 21B | Often (30–79%) | In 1 condition |
| WDR19WD repeat domain 19 | Often (30–79%) | In 1 condition |
| ACTA2actin alpha 2, smooth muscle | Sometimes (5–29%) | In 1 condition |
| ASAH1N-acylsphingosine amidohydrolase 1 | Sometimes (5–29%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| EFEMP2EGF-like fibulin extracellular matrix protein 2 | Sometimes (5–29%) | In 1 condition |
| ELNelastin | Sometimes (5–29%) | In 1 condition |
| FBN1fibrillin 1 | Sometimes (5–29%) | In 1 condition |
| FOXE3forkhead box E3 | Sometimes (5–29%) | In 1 condition |
| HEY2hes related family bHLH transcription factor with YRPW motif 2 | Sometimes (5–29%) | In 1 condition |
| LOXlysyl oxidase | Sometimes (5–29%) | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Sometimes (5–29%) | In 1 condition |
| MAT2Amethionine adenosyltransferase 2A | Sometimes (5–29%) | In 1 condition |
| MFAP5microfibril associated protein 5 | Sometimes (5–29%) | In 1 condition |
| MYH11myosin heavy chain 11 | Sometimes (5–29%) | In 1 condition |
Show 17 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MYLKmyosin light chain kinase | Sometimes (5–29%) | In 1 condition |
| PRKG1protein kinase cGMP-dependent 1 | Sometimes (5–29%) | In 1 condition |
| PTPN11protein tyrosine phosphatase non-receptor type 11 | Sometimes (5–29%) | In 1 condition |
| RIT1Ras like without CAAX 1 | Sometimes (5–29%) | In 1 condition |
| RNF135ring finger protein 135 | Sometimes (5–29%) | In 1 condition |
| SMAD2SMAD family member 2 | Sometimes (5–29%) | In 2 conditions |
| SMAD3SMAD family member 3 | Sometimes (5–29%) | In 2 conditions |
| SMAD4SMAD family member 4 | Sometimes (5–29%) | In 1 condition |
| SPRED1sprouty related EVH1 domain containing 1 | Sometimes (5–29%) | In 1 condition |
| TGFB3transforming growth factor beta 3 | Sometimes (5–29%) | In 1 condition |
| THSD4thrombospondin type 1 domain containing 4 | Sometimes (5–29%) | In 1 condition |
| ABCC6ATP binding cassette subfamily C member 6 | Not recorded | In 1 condition |
| LZTR1leucine zipper like post translational regulator 1 | Not recorded | In 1 condition |
| PIEZO2piezo type mechanosensitive ion channel component 2 | Not recorded | In 1 condition |
| PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha | Not recorded | In 1 condition |
| PTCH1patched 1 | Not recorded | In 1 condition |
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Not recorded | In 2 conditions |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.19-9814e911.
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