Trait
Premature breast development
Clinical name: Premature thelarche
Premature development of the breasts.
Summary
- Body system
- Abnormality of the endocrine system
Reference genomeGRCh38hg38
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Get my Genome Test18 genes linked to Premature breast development
Changes in these genes cause rare conditions in which Premature breast development is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| KDM6Alysine demethylase 6A | Often (30–79%) | In 2 conditions |
| KMT2Dlysine methyltransferase 2D | Often (30–79%) | In 2 conditions |
| CYP19A1cytochrome P450 family 19 subfamily A member 1 | Sometimes (5–29%) | In 1 condition |
| EIF5Aeukaryotic translation initiation factor 5A | Sometimes (5–29%) | In 1 condition |
| MMP14matrix metallopeptidase 14 | Sometimes (5–29%) | In 1 condition |
| MMP2matrix metallopeptidase 2 | Sometimes (5–29%) | In 1 condition |
| TANGO2transport and golgi organization 2 homolog | Sometimes (5–29%) | In 1 condition |
| ALKALK receptor tyrosine kinase | Rarely (1–4%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Rarely (1–4%) | In 1 condition |
| CYP11B1cytochrome P450 family 11 subfamily B member 1 | Rarely (1–4%) | In 1 condition |
| DYRK1Adual specificity tyrosine phosphorylation regulated kinase 1A | Rarely (1–4%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Rarely (1–4%) | In 1 condition |
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Rarely (1–4%) | In 1 condition |
| SOX5SRY-box transcription factor 5 | Rarely (1–4%) | In 1 condition |
| ZEB2zinc finger E-box binding homeobox 2 | Rarely (1–4%) | In 1 condition |
| CREBBPCREB binding lysine acetyltransferase | Not recorded | In 1 condition |
| EP300EP300 lysine acetyltransferase | Not recorded | In 1 condition |
| MKRN3makorin ring finger protein 3 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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