Trait
General overgrowth
Clinical name: Overgrowth
Excessive postnatal growth which may comprise increased weight, increased length, and/or increased head circumference.
Summary
- Body system
- Growth abnormality
Reference genomeGRCh38hg38
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Get my Genome Test47 genes linked to General overgrowth
Changes in these genes cause rare conditions in which General overgrowth is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DICER1dicer 1, ribonuclease III | Always | In 1 condition |
| DNMT3ADNA methyltransferase 3 alpha | Always | In 1 condition |
| EEDembryonic ectoderm development | Always | In 1 condition |
| EFEMP2EGF-like fibulin extracellular matrix protein 2 | Always | In 1 condition |
| EZH2enhancer of zeste 2 polycomb repressive complex 2 subunit | Always | In 1 condition |
| FIBPFGF1 intracellular binding protein | Always | In 1 condition |
| GPR101G protein-coupled receptor 101 | Always | In 1 condition |
| KDM2Blysine demethylase 2B | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| NFIXnuclear factor I X | Always | In 1 condition |
| PDGFRBplatelet derived growth factor receptor beta | Always | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Always | In 5 conditions |
| SPIN4spindlin family member 4 | Always | In 1 condition |
| TGFB3transforming growth factor beta 3 | Always | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Very often (80–99%) | In 1 condition |
| ESR1estrogen receptor 1 | Very often (80–99%) | In 1 condition |
| HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | Very often (80–99%) | In 1 condition |
| RNF135ring finger protein 135 | Very often (80–99%) | In 1 condition |
| SUZ12SUZ12 polycomb repressive complex 2 subunit | Very often (80–99%) | In 1 condition |
| ARHGEF9Cdc42 guanine nucleotide exchange factor 9 | Often (30–79%) | In 1 condition |
| EHMT1euchromatic histone lysine methyltransferase 1 | Often (30–79%) | In 1 condition |
| GPC3glypican 3 | Often (30–79%) | In 1 condition |
| KMT2Clysine methyltransferase 2C | Often (30–79%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Often (30–79%) | In 1 condition |
| PTENphosphatase and tensin homolog | Often (30–79%) | In 1 condition |
| CAMK2Acalcium/calmodulin dependent protein kinase II alpha | Sometimes (5–29%) | In 1 condition |
| DLK1delta like non-canonical Notch ligand 1 | Sometimes (5–29%) | In 2 conditions |
| H3-3BH3.3 histone B | Sometimes (5–29%) | In 1 condition |
| HECTD4HECT domain E3 ubiquitin protein ligase 4 | Sometimes (5–29%) | In 1 condition |
| HNRNPKheterogeneous nuclear ribonucleoprotein K | Sometimes (5–29%) | In 2 conditions |
| MEG3maternally expressed 3 | Sometimes (5–29%) | In 2 conditions |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Sometimes (5–29%) | In 2 conditions |
| PIK3R2phosphoinositide-3-kinase regulatory subunit 2 | Sometimes (5–29%) | In 1 condition |
| RTL1retrotransposon Gag like 1 | Sometimes (5–29%) | In 2 conditions |
| CDKN1Ccyclin dependent kinase inhibitor 1C | Not recorded | In 1 condition |
| FAM20AFAM20A golgi associated secretory pathway pseudokinase | Not recorded | In 1 condition |
| FBLN5fibulin 5 | Not recorded | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Not recorded | In 2 conditions |
| HSPG2heparan sulfate proteoglycan 2 | Not recorded | In 1 condition |
| IGF2insulin like growth factor 2 | Not recorded | In 1 condition |
Show 7 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| KCNQ1potassium voltage-gated channel subfamily Q member 1 | Not recorded | In 1 condition |
| KCNQ1OT1KCNQ1 opposite strand/antisense transcript 1 | Not recorded | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| NF1neurofibromin 1 | Not recorded | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Not recorded | In 1 condition |
| SETD2SET domain containing 2, histone lysine methyltransferase | Not recorded | In 1 condition |
| SOSTsclerostin | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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