Trait
Hemolytic anemia
A type of anemia caused by premature destruction of red blood cells (hemolysis).
Summary
- Also called
- Haemolytic anaemia, Haemolytic anemia, Hemolytic anaemia, Increased hemolysis
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Hemolytic anemia, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test99 genes linked to Hemolytic anemia
Changes in these genes cause rare conditions in which Hemolytic anemia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ANK1ankyrin 1 | Always | In 2 conditions |
| ATP11CATPase phospholipid transporting 11C (ATP11C blood group) | Always | In 1 condition |
| CDAN1codanin 1 | Always | In 1 condition |
| CYBC1cytochrome b-245 chaperone 1 | Always | In 1 condition |
| GATA1GATA binding protein 1 | Always | In 3 conditions |
| GCLCglutamate-cysteine ligase catalytic subunit | Always | In 2 conditions |
| GSSglutathione synthetase | Always | In 2 conditions |
| HMOX1heme oxygenase 1 | Always | In 2 conditions |
| IL2RAinterleukin 2 receptor subunit alpha | Always | In 1 condition |
| KCNN4potassium calcium-activated channel subfamily N member 4 | Always | In 2 conditions |
| KLF1KLF transcription factor 1 | Always | In 2 conditions |
| NT5C3A5'-nucleotidase, cytosolic IIIA | Always | In 1 condition |
| PAN2poly(A) specific ribonuclease subunit PAN2 | Always | In 1 condition |
| PGK1phosphoglycerate kinase 1 | Always | In 2 conditions |
| PIGTphosphatidylinositol glycan anchor biosynthesis class T | Always | In 1 condition |
| RHAGRh associated glycoprotein | Always | In 4 conditions |
| RHCERh blood group CcEe antigens | Always | In 2 conditions |
| SLC2A1solute carrier family 2 member 1 | Always | In 2 conditions |
| SLC4A1solute carrier family 4 member 1 (Diego blood group) | Always | In 6 conditions |
| SPTBspectrin beta, erythrocytic | Always | In 2 conditions |
| CD46CD46 molecule | Very often (80–99%) | In 1 condition |
| CFHcomplement factor H | Very often (80–99%) | In 1 condition |
| CFIcomplement factor I | Very often (80–99%) | In 1 condition |
| HBBhemoglobin subunit beta | Very often (80–99%) | In 2 conditions |
| HELLPARHELLP associated long non-coding RNA | Very often (80–99%) | In 1 condition |
| NBNnibrin | Very often (80–99%) | In 1 condition |
| PIEZO1piezo type mechanosensitive ion channel component 1 (Er blood group) | Very often (80–99%) | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Very often (80–99%) | In 1 condition |
| RHDRh blood group D antigen | Very often (80–99%) | In 1 condition |
| ABCG5ATP binding cassette subfamily G member 5 | Often (30–79%) | In 1 condition |
| ABCG8ATP binding cassette subfamily G member 8 | Often (30–79%) | In 1 condition |
| ALDOAaldolase, fructose-bisphosphate A | Often (30–79%) | In 1 condition |
| ATP7BATPase copper transporting beta | Often (30–79%) | In 2 conditions |
| C1GALT1C1C1GALT1 specific chaperone 1 | Often (30–79%) | In 1 condition |
| DEF6DEF6 guanine nucleotide exchange factor | Often (30–79%) | In 1 condition |
| TPP2tripeptidyl peptidase 2 | Often (30–79%) | In 1 condition |
| UROSuroporphyrinogen III synthase | Often (30–79%) | In 2 conditions |
| WASWASP actin nucleation promoting factor | Often (30–79%) | In 1 condition |
| ADARadenosine deaminase RNA specific | Sometimes (5–29%) | In 1 condition |
| BANK1B cell scaffold protein with ankyrin repeats 1 | Sometimes (5–29%) | In 1 condition |
Show 59 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| BLKBLK proto-oncogene, Src family tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Sometimes (5–29%) | In 1 condition |
| C4Bcomplement C4B (Chido/Rodgers blood group) | Sometimes (5–29%) | In 1 condition |
| CR2complement C3d receptor 2 | Sometimes (5–29%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Sometimes (5–29%) | In 1 condition |
| DGKEdiacylglycerol kinase epsilon | Sometimes (5–29%) | In 1 condition |
| DNASE1deoxyribonuclease 1 | Sometimes (5–29%) | In 2 conditions |
| EPB41erythrocyte membrane protein band 4.1 | Sometimes (5–29%) | In 2 conditions |
| ETS1ETS proto-oncogene 1, transcription factor | Sometimes (5–29%) | In 1 condition |
| FCGR2BFc gamma receptor IIb | Sometimes (5–29%) | In 2 conditions |
| FCGR3BFc gamma receptor IIIb | Sometimes (5–29%) | In 1 condition |
| GNB2G protein subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| GYPCglycophorin C (Gerbich blood group) | Sometimes (5–29%) | In 1 condition |
| HGDhomogentisate 1,2-dioxygenase | Sometimes (5–29%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 2 conditions |
| IFIH1interferon induced with helicase C domain 1 | Sometimes (5–29%) | In 1 condition |
| IGHG1immunoglobulin heavy constant gamma 1 (G1m marker) | Sometimes (5–29%) | In 1 condition |
| IL10interleukin 10 | Sometimes (5–29%) | In 1 condition |
| IRAK1interleukin 1 receptor associated kinase 1 | Sometimes (5–29%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Sometimes (5–29%) | In 1 condition |
| ITGAMintegrin subunit alpha M | Sometimes (5–29%) | In 1 condition |
| JAZF1JAZF zinc finger 1 | Sometimes (5–29%) | In 1 condition |
| KIAA0319LKIAA0319 like | Sometimes (5–29%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Sometimes (5–29%) | In 1 condition |
| PDCD1programmed cell death 1 | Sometimes (5–29%) | In 1 condition |
| PGM3phosphoglucomutase 3 | Sometimes (5–29%) | In 2 conditions |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Sometimes (5–29%) | In 1 condition |
| PXKPX domain containing serine/threonine kinase like | Sometimes (5–29%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| SPP1secreted phosphoprotein 1 | Sometimes (5–29%) | In 1 condition |
| SPTA1spectrin alpha, erythrocytic 1 | Sometimes (5–29%) | In 4 conditions |
| STAT4signal transducer and activator of transcription 4 | Sometimes (5–29%) | In 1 condition |
| TLR7toll like receptor 7 | Sometimes (5–29%) | In 1 condition |
| TNFAIP3TNF alpha induced protein 3 | Sometimes (5–29%) | In 2 conditions |
| TNFSF4TNF superfamily member 4 | Sometimes (5–29%) | In 1 condition |
| TNIP1TNFAIP3 interacting protein 1 | Sometimes (5–29%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Sometimes (5–29%) | In 2 conditions |
| UBE2L3ubiquitin conjugating enzyme E2 L3 | Sometimes (5–29%) | In 1 condition |
| URODuroporphyrinogen decarboxylase | Sometimes (5–29%) | In 1 condition |
| BTNL2butyrophilin like 2 | Rarely (1–4%) | In 1 condition |
| AK1adenylate kinase 1 | Not recorded | In 1 condition |
| ALADaminolevulinate dehydratase | Not recorded | In 1 condition |
| CD40LGCD40 ligand | Not recorded | In 1 condition |
| CD59CD59 molecule (CD59 blood group) | Not recorded | In 1 condition |
| COL4A1collagen type IV alpha 1 chain | Not recorded | In 1 condition |
| CPOXcoproporphyrinogen oxidase | Not recorded | In 1 condition |
| EPB42erythrocyte membrane protein band 4.2 | Not recorded | In 1 condition |
| FCGR2AFc gamma receptor IIa | Not recorded | In 1 condition |
| FECHferrochelatase | Not recorded | In 1 condition |
| GALTgalactose-1-phosphate uridylyltransferase | Not recorded | In 1 condition |
| GP1BAglycoprotein Ib platelet subunit alpha | Not recorded | In 1 condition |
| HBA1hemoglobin subunit alpha 1 | Not recorded | In 1 condition |
| HBA2hemoglobin subunit alpha 2 | Not recorded | In 1 condition |
| KDM6Alysine demethylase 6A | Not recorded | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Not recorded | In 1 condition |
| LCATlecithin-cholesterol acyltransferase | Not recorded | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Not recorded | In 1 condition |
| PFKMphosphofructokinase, muscle | Not recorded | In 1 condition |
| TPI1triosephosphate isomerase 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
- Autoimmune hemolytic anemia48 genes
- Microangiopathic hemolytic anemia15 genes
- Nonspherocytic hemolytic anemia11 genes
- Coombs-positive hemolytic anemia10 genes
- Congenital hemolytic anemia8 genes
- Spontaneous hemolytic crises7 genes
- Chronic hemolytic anemia5 genes
- Episodic hemolytic anemia3 genes
- Fava bean-induced hemolytic anemia3 genes
- Heinz body anemia3 genes
- Compensated hemolytic anemia1 gene
- Drug-sensitive hemolytic anemia1 gene
- Exercise-induced hemolysis1 gene
- Increased red cell hemolysis by shear stress1 gene
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks