Trait
Corneal opacity
A reduction of corneal clarity.
Summary
- Also called
- Corneal clouding, Corneal opacities, Reduction of corneal clarity, Scarring or clouding of the cornea of the eye
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Corneal opacity, and the rest of your genome, with one test.
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Get my Genome Test166 genes linked to Corneal opacity
Changes in these genes cause rare conditions in which Corneal opacity is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Always | In 2 conditions |
| ARSBarylsulfatase B | Always | In 1 condition |
| B3GALT6beta-1,3-galactosyltransferase 6 | Always | In 1 condition |
| BUD13BUD13 spliceosome associated protein | Always | In 1 condition |
| CHUKcomponent of inhibitor of nuclear factor kappa B kinase complex | Always | In 1 condition |
| FKRPfukutin related protein | Always | In 3 conditions |
| FKTNfukutin | Always | In 2 conditions |
| HYAL2hyaluronidase 2 | Always | In 1 condition |
| IDUAalpha-L-iduronidase | Always | In 6 conditions |
| KERAkeratocan | Always | In 1 condition |
| LARGE1LARGE xylosyl- and glucuronyltransferase 1 | Always | In 2 conditions |
| NDPnorrin cystine knot growth factor NDP | Always | In 3 conditions |
| NGLY1N-glycanase 1 | Always | In 1 condition |
| PLCB3phospholipase C beta 3 | Always | In 1 condition |
| POMT1protein O-mannosyltransferase 1 | Always | In 2 conditions |
| POMT2protein O-mannosyltransferase 2 | Always | In 2 conditions |
| PXDNperoxidasin | Always | In 1 condition |
| RBM8ARNA binding motif protein 8A | Always | In 1 condition |
| TGFBItransforming growth factor beta induced | Always | In 2 conditions |
| AGBL1AGBL carboxypeptidase 1 | Very often (80–99%) | In 1 condition |
| ATOH7atonal bHLH transcription factor 7 | Very often (80–99%) | In 2 conditions |
| B3GLCTbeta 3-glucosyltransferase | Very often (80–99%) | In 1 condition |
| BMP4bone morphogenetic protein 4 | Very often (80–99%) | In 1 condition |
| BUB1BUB1 mitotic checkpoint serine/threonine kinase | Very often (80–99%) | In 1 condition |
| BUB1BBUB1 mitotic checkpoint serine/threonine kinase B | Very often (80–99%) | In 1 condition |
| BUB3BUB3 mitotic checkpoint protein | Very often (80–99%) | In 1 condition |
| CEP57centrosomal protein 57 | Very often (80–99%) | In 1 condition |
| COL11A1collagen type XI alpha 1 chain | Very often (80–99%) | In 1 condition |
| COL8A2collagen type VIII alpha 2 chain | Very often (80–99%) | In 3 conditions |
| COX7Bcytochrome c oxidase subunit 7B | Very often (80–99%) | In 1 condition |
| CTSAcathepsin A | Very often (80–99%) | In 1 condition |
| FOXE3forkhead box E3 | Very often (80–99%) | In 2 conditions |
| FZD4frizzled class receptor 4 | Very often (80–99%) | In 1 condition |
| GLAgalactosidase alpha | Very often (80–99%) | In 1 condition |
| GUSBglucuronidase beta | Very often (80–99%) | In 2 conditions |
| HCCSholocytochrome c synthase | Very often (80–99%) | In 1 condition |
| LCATlecithin-cholesterol acyltransferase | Very often (80–99%) | In 1 condition |
| MAB21L1mab-21 like 1 | Very often (80–99%) | In 1 condition |
| MCOLN1mucolipin TRP cation channel 1 | Very often (80–99%) | In 2 conditions |
| NDUFB11NADH:ubiquinone oxidoreductase subunit B11 | Very often (80–99%) | In 1 condition |
Show 126 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| NEU1neuraminidase 1 | Very often (80–99%) | In 3 conditions |
| PEX1peroxisomal biogenesis factor 1 | Very often (80–99%) | In 1 condition |
| PEX10peroxisomal biogenesis factor 10 | Very often (80–99%) | In 1 condition |
| PEX11Bperoxisomal biogenesis factor 11 beta | Very often (80–99%) | In 1 condition |
| PEX12peroxisomal biogenesis factor 12 | Very often (80–99%) | In 1 condition |
| PEX13peroxisomal biogenesis factor 13 | Very often (80–99%) | In 1 condition |
| PEX14peroxisomal biogenesis factor 14 | Very often (80–99%) | In 1 condition |
| PEX16peroxisomal biogenesis factor 16 | Very often (80–99%) | In 1 condition |
| PEX19peroxisomal biogenesis factor 19 | Very often (80–99%) | In 1 condition |
| PEX2peroxisomal biogenesis factor 2 | Very often (80–99%) | In 1 condition |
| PEX26peroxisomal biogenesis factor 26 | Very often (80–99%) | In 1 condition |
| PEX3peroxisomal biogenesis factor 3 | Very often (80–99%) | In 1 condition |
| PEX5peroxisomal biogenesis factor 5 | Very often (80–99%) | In 1 condition |
| PEX6peroxisomal biogenesis factor 6 | Very often (80–99%) | In 1 condition |
| SLC4A11solute carrier family 4 member 11 | Very often (80–99%) | In 3 conditions |
| TATtyrosine aminotransferase | Very often (80–99%) | In 1 condition |
| TCF4transcription factor 4 | Very often (80–99%) | In 2 conditions |
| TRIP13thyroid hormone receptor interactor 13 | Very often (80–99%) | In 1 condition |
| ZEB1zinc finger E-box binding homeobox 1 | Very often (80–99%) | In 2 conditions |
| B3GALNT2beta-1,3-N-acetylgalactosaminyltransferase 2 | Often (30–79%) | In 1 condition |
| B4GAT1beta-1,4-glucuronyltransferase 1 | Often (30–79%) | In 1 condition |
| COL4A1collagen type IV alpha 1 chain | Often (30–79%) | In 2 conditions |
| CRPPACDP-L-ribitol pyrophosphorylase A | Often (30–79%) | In 1 condition |
| CYP1B1cytochrome P450 family 1 subfamily B member 1 | Often (30–79%) | In 2 conditions |
| DAG1dystroglycan 1 | Often (30–79%) | In 1 condition |
| DNA2DNA replication helicase/nuclease 2 | Often (30–79%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 1 condition |
| FOXC1forkhead box C1 | Often (30–79%) | In 1 condition |
| FUCA1alpha-L-fucosidase 1 | Often (30–79%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Often (30–79%) | In 2 conditions |
| GLB1galactosidase beta 1 | Often (30–79%) | In 1 condition |
| GON4Lgon-4 like | Often (30–79%) | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Often (30–79%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Often (30–79%) | In 2 conditions |
| LRP5LDL receptor related protein 5 | Often (30–79%) | In 1 condition |
| LTBP2latent transforming growth factor beta binding protein 2 | Often (30–79%) | In 2 conditions |
| MAFBMAF bZIP transcription factor B | Often (30–79%) | In 1 condition |
| MMP2matrix metallopeptidase 2 | Often (30–79%) | In 1 condition |
| MYOCmyocilin | Often (30–79%) | In 1 condition |
| NEUROG1neurogenin 1 | Often (30–79%) | In 1 condition |
| PAX6paired box 6 | Often (30–79%) | In 2 conditions |
| PIGLphosphatidylinositol glycan anchor biosynthesis class L | Often (30–79%) | In 1 condition |
| PIGNphosphatidylinositol glycan anchor biosynthesis class N | Often (30–79%) | In 1 condition |
| PLXND1plexin D1 | Often (30–79%) | In 1 condition |
| POLR3ARNA polymerase III subunit A | Often (30–79%) | In 1 condition |
| POMGNT1protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | Often (30–79%) | In 1 condition |
| POMGNT2protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) | Often (30–79%) | In 1 condition |
| POMKprotein O-mannose kinase | Often (30–79%) | In 1 condition |
| REV3LREV3 like, DNA directed polymerase zeta catalytic subunit | Often (30–79%) | In 1 condition |
| RIPK4receptor interacting serine/threonine kinase 4 | Often (30–79%) | In 1 condition |
| RXYLT1ribitol xylosyltransferase 1 | Often (30–79%) | In 1 condition |
| ST14ST14 transmembrane serine protease matriptase | Often (30–79%) | In 1 condition |
| STSsteroid sulfatase | Often (30–79%) | In 1 condition |
| SUMF1sulfatase modifying factor 1 | Often (30–79%) | In 2 conditions |
| TEKTEK receptor tyrosine kinase | Often (30–79%) | In 1 condition |
| TRIM44TRIM family member 44 | Often (30–79%) | In 1 condition |
| TWIST2twist family bHLH transcription factor 2 | Often (30–79%) | In 1 condition |
| ABCA1ATP binding cassette subfamily A member 1 | Sometimes (5–29%) | In 1 condition |
| ASAH1N-acylsphingosine amidohydrolase 1 | Sometimes (5–29%) | In 1 condition |
| ATAD3AATPase family AAA domain containing 3A | Sometimes (5–29%) | In 2 conditions |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Sometimes (5–29%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Sometimes (5–29%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Sometimes (5–29%) | In 1 condition |
| COLEC10collectin subfamily member 10 | Sometimes (5–29%) | In 1 condition |
| CRYAAcrystallin alpha A | Sometimes (5–29%) | In 1 condition |
| CRYBA4crystallin beta A4 | Sometimes (5–29%) | In 1 condition |
| CRYBB1crystallin beta B1 | Sometimes (5–29%) | In 1 condition |
| CRYBB2crystallin beta B2 | Sometimes (5–29%) | In 1 condition |
| CRYGCcrystallin gamma C | Sometimes (5–29%) | In 1 condition |
| CRYGDcrystallin gamma D | Sometimes (5–29%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Sometimes (5–29%) | In 1 condition |
| DYRK1Adual specificity tyrosine phosphorylation regulated kinase 1A | Sometimes (5–29%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Sometimes (5–29%) | In 1 condition |
| ELNelastin | Sometimes (5–29%) | In 2 conditions |
| ELP1elongator acetyltransferase complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2 | Sometimes (5–29%) | In 1 condition |
| FBLN5fibulin 5 | Sometimes (5–29%) | In 1 condition |
| FERMT1FERM domain containing kindlin 1 | Sometimes (5–29%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Sometimes (5–29%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Sometimes (5–29%) | In 1 condition |
| GJA8gap junction protein alpha 8 | Sometimes (5–29%) | In 1 condition |
| GJB3gap junction protein beta 3 | Sometimes (5–29%) | In 1 condition |
| GJB4gap junction protein beta 4 | Sometimes (5–29%) | In 1 condition |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Sometimes (5–29%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Sometimes (5–29%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Sometimes (5–29%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Sometimes (5–29%) | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| KDSR3-ketodihydrosphingosine reductase | Sometimes (5–29%) | In 1 condition |
| KRT14keratin 14 | Sometimes (5–29%) | In 1 condition |
| KRT5keratin 5 | Sometimes (5–29%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Sometimes (5–29%) | In 1 condition |
| LMNAlamin A/C | Sometimes (5–29%) | In 1 condition |
| MAFMAF bZIP transcription factor | Sometimes (5–29%) | In 2 conditions |
| MAN2B1mannosidase alpha class 2B member 1 | Sometimes (5–29%) | In 2 conditions |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Sometimes (5–29%) | In 1 condition |
| METTL27methyltransferase like 27 | Sometimes (5–29%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Sometimes (5–29%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Sometimes (5–29%) | In 1 condition |
| OTUD5OTU deubiquitinase 5 | Sometimes (5–29%) | In 1 condition |
| PCYT1Aphosphate cytidylyltransferase 1A, choline | Sometimes (5–29%) | In 2 conditions |
| PDGFRBplatelet derived growth factor receptor beta | Sometimes (5–29%) | In 1 condition |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Sometimes (5–29%) | In 1 condition |
| PORCNporcupine O-acyltransferase | Sometimes (5–29%) | In 1 condition |
| PPP1R13Lprotein phosphatase 1 regulatory subunit 13 like | Sometimes (5–29%) | In 1 condition |
| RFC2replication factor C subunit 2 | Sometimes (5–29%) | In 1 condition |
| SMARCAL1SNF2 related chromatin remodeling annealing helicase 1 | Sometimes (5–29%) | In 1 condition |
| STX1Asyntaxin 1A | Sometimes (5–29%) | In 1 condition |
| TBCEtubulin folding cofactor E | Sometimes (5–29%) | In 1 condition |
| TBCKTBC1 domain containing kinase | Sometimes (5–29%) | In 2 conditions |
| TBL2transducin beta like 2 | Sometimes (5–29%) | In 1 condition |
| TMEM270transmembrane protein 270 | Sometimes (5–29%) | In 1 condition |
| TRPV3transient receptor potential cation channel subfamily V member 3 | Sometimes (5–29%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Sometimes (5–29%) | In 1 condition |
| YAP1Yes1 associated transcriptional regulator | Sometimes (5–29%) | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Sometimes (5–29%) | In 1 condition |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Rarely (1–4%) | In 1 condition |
| GRHL2grainyhead like transcription factor 2 | Rarely (1–4%) | In 1 condition |
| MT-CYBmitochondrially encoded cytochrome b | Rarely (1–4%) | In 1 condition |
| OVOL2ovo like zinc finger 2 | Rarely (1–4%) | In 2 conditions |
| VSX1visual system homeobox 1 | Rarely (1–4%) | In 1 condition |
| DYMdymeclin | Not recorded | In 1 condition |
| FLNBfilamin B | Not recorded | In 1 condition |
| FRAS1Fraser extracellular matrix complex subunit 1 | Not recorded | In 1 condition |
| KIF11kinesin family member 11 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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