Trait
Strawberry mark
Clinical name: Hemangioma
A hemangioma is a benign tumor characterized by blood-filled spaces lined by benign endothelial cells. A hemangioma characterized by large endothelial spaces (caverns) is called a cavernous hemangioma (in contrast to a hemangioma with small endothelial spaces, which is called capillary hemangioma).
Summary
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test77 genes linked to Strawberry mark
Changes in these genes cause rare conditions in which Strawberry mark is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CILK1ciliogenesis associated kinase 1 | Always | In 1 condition |
| FBXO28F-box protein 28 | Always | In 1 condition |
| PPP2R5Cprotein phosphatase 2 regulatory subunit B'gamma | Always | In 1 condition |
| SPOUT1SPOUT domain containing methyltransferase 1 | Always | In 1 condition |
| AGGF1angiogenic factor with G-patch and FHA domains 1 | Very often (80–99%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Very often (80–99%) | In 1 condition |
| IDH2isocitrate dehydrogenase (NADP(+)) 2 | Very often (80–99%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Very often (80–99%) | In 2 conditions |
| PTENphosphatase and tensin homolog | Very often (80–99%) | In 2 conditions |
| PTH1Rparathyroid hormone 1 receptor | Very often (80–99%) | In 1 condition |
| TFAP2Atranscription factor AP-2 alpha | Very often (80–99%) | In 1 condition |
| THSD1thrombospondin type 1 domain containing 1 | Very often (80–99%) | In 1 condition |
| BMPR1Abone morphogenetic protein receptor type 1A | Often (30–79%) | In 1 condition |
| CCM2CCM2 scaffold protein | Often (30–79%) | In 1 condition |
| CPLX1complexin 1 | Often (30–79%) | In 2 conditions |
| CTBP1C-terminal binding protein 1 | Often (30–79%) | In 2 conditions |
| CYP26C1cytochrome P450 family 26 subfamily C member 1 | Often (30–79%) | In 1 condition |
| FGFRL1fibroblast growth factor receptor like 1 | Often (30–79%) | In 1 condition |
| KRIT1KRIT1 ankyrin repeat containing | Often (30–79%) | In 1 condition |
| LETM1leucine zipper and EF-hand containing transmembrane protein 1 | Often (30–79%) | In 2 conditions |
| NELFAnegative elongation factor complex member A | Often (30–79%) | In 1 condition |
| NSD2nuclear receptor binding SET domain protein 2 | Often (30–79%) | In 2 conditions |
| PDCD10programmed cell death 10 | Often (30–79%) | In 1 condition |
| PIGGphosphatidylinositol glycan anchor biosynthesis class G (EMM blood group) | Often (30–79%) | In 1 condition |
| SHOC2SHOC2 leucine rich repeat scaffold protein | Often (30–79%) | In 1 condition |
| ANTXR1ANTXR cell adhesion molecule 1 | Sometimes (5–29%) | In 1 condition |
| ARID1BAT-rich interaction domain 1B | Sometimes (5–29%) | In 1 condition |
| CDONcell adhesion associated, oncogene regulated | Sometimes (5–29%) | In 1 condition |
| CLPBClpB family mitochondrial disaggregase | Sometimes (5–29%) | In 1 condition |
| CRELD1CRELD disulfide isomerase 1 | Sometimes (5–29%) | In 1 condition |
| CRIPTOcripto, EGF-CFC family member | Sometimes (5–29%) | In 1 condition |
| DISP1dispatched RND transporter family member 1 | Sometimes (5–29%) | In 1 condition |
| DLL1delta like canonical Notch ligand 1 | Sometimes (5–29%) | In 1 condition |
| ELANEelastase, neutrophil expressed | Sometimes (5–29%) | In 1 condition |
| FBXO22F-box protein 22 | Sometimes (5–29%) | In 1 condition |
| FGF8fibroblast growth factor 8 | Sometimes (5–29%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Sometimes (5–29%) | In 1 condition |
| FOXH1forkhead box H1 | Sometimes (5–29%) | In 1 condition |
| GAS1growth arrest specific 1 | Sometimes (5–29%) | In 1 condition |
| GFI1growth factor independent 1 transcriptional repressor | Sometimes (5–29%) | In 1 condition |
Show 37 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| GLI2GLI family zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| H4C5H4 clustered histone 5 | Sometimes (5–29%) | In 1 condition |
| KDM6Blysine demethylase 6B | Sometimes (5–29%) | In 1 condition |
| MAP2K2mitogen-activated protein kinase kinase 2 | Sometimes (5–29%) | In 1 condition |
| MSL3MSL complex subunit 3 | Sometimes (5–29%) | In 1 condition |
| MTORmechanistic target of rapamycin kinase | Sometimes (5–29%) | In 1 condition |
| NODALnodal growth differentiation factor | Sometimes (5–29%) | In 1 condition |
| PTCH1patched 1 | Sometimes (5–29%) | In 1 condition |
| SHHsonic hedgehog signaling molecule | Sometimes (5–29%) | In 1 condition |
| SIX3SIX homeobox 3 | Sometimes (5–29%) | In 1 condition |
| SPENspen family transcriptional repressor | Sometimes (5–29%) | In 1 condition |
| SRP19signal recognition particle 19 | Sometimes (5–29%) | In 1 condition |
| SUFUSUFU negative regulator of hedgehog signaling | Sometimes (5–29%) | In 1 condition |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Sometimes (5–29%) | In 1 condition |
| TGIF1TGFB induced factor homeobox 1 | Sometimes (5–29%) | In 1 condition |
| ZIC2Zic family zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| APC2APC regulator of Wnt signaling pathway 2 | Rarely (1–4%) | In 1 condition |
| CALRcalreticulin | Rarely (1–4%) | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Rarely (1–4%) | In 2 conditions |
| JAK2Janus kinase 2 | Rarely (1–4%) | In 1 condition |
| MPLMPL proto-oncogene, thrombopoietin receptor | Rarely (1–4%) | In 1 condition |
| NF1neurofibromin 1 | Rarely (1–4%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Rarely (1–4%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Rarely (1–4%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Not recorded | In 1 condition |
| CTSAcathepsin A | Not recorded | In 1 condition |
| DPM1dolichyl-phosphate mannosyltransferase subunit 1, catalytic | Not recorded | In 1 condition |
| FLT4fms related receptor tyrosine kinase 4 | Not recorded | In 1 condition |
| GPC6glypican 6 | Not recorded | In 1 condition |
| KIF1Bkinesin family member 1B | Not recorded | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| MAXMYC associated transcriptional regulator X | Not recorded | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Not recorded | In 1 condition |
| RETret proto-oncogene | Not recorded | In 1 condition |
| SEC23BSEC23 homolog B, COPII component | Not recorded | In 1 condition |
| TMEM127transmembrane protein 127 | Not recorded | In 1 condition |
| VHLvon Hippel-Lindau tumor suppressor | Not recorded | In 2 conditions |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
- Strawberry birthmark26 genes
- Collection of dilated blood vessels that forms mass24 genes
- Arachnoid hemangiomatosis16 genes
- Retinal capillary hemangioma16 genes
- Facial hemangioma12 genes
- Choroidal hemangioma5 genes
- Glabellar hemangioma5 genes
- Lumbosacral hemangioma4 genes
- Hemangiomatosis3 genes
- Hemangioma of the lip1 gene
- Visceral hemangioma
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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