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Trait

Nevus sebaceous

A congenital, hairless plaque consisting of overgrown epidermis, sebaceous glands, hair follicles, apocrine glands and connective tissue. They are a variant of epidermal naevi. Sebaceous naevi most often appear on the scalp, but they may also arise on the face, neck or forehead. At birth, a sevaceous nevus typically appears as a solitary, smooth, yellow-orange hairless patch. Sebaceous naevi become more pronounced around adolescence, often appearing bumpy, warty or scaly.

HPO HP:0010815

Summary

Also called
Naevus sebaceous, Organoid nevus, Sebaceous mole, Sebaceous naevus, Sebaceous nevus
Body system
Abnormality of the integument

5 genes linked to Nevus sebaceous

Changes in these genes cause rare conditions in which Nevus sebaceous is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
BRAFB-Raf proto-oncogene, serine/threonine kinaseSometimes (5–29%)In 1 condition
SMOsmoothened, frizzled class receptorSometimes (5–29%)In 1 condition
HRASHRas proto-oncogene, GTPaseNot recordedIn 1 condition
KRASKRas proto-oncogene, GTPaseNot recordedIn 1 condition
NRASNRAS proto-oncogene, GTPaseNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Epidermal nevus

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

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