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Trait
Poor social interactions
Clinical name: Reduced social responsiveness
A reduced ability to participate in the back-and-forth flow of social interaction appropriate to culture and developmental level, which is normally characterized by an influence of the behavior of one person on the behavior of another person. This results in difficulty interacting with others through emotional, physical, or verbal communication.
Summary
- Also called
- Impaired social interaction, Impaired social interactions, Impaired social reciprocity
- Body system
- Abnormality of the nervous system
Poor social interactionsHP:0012760
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Read the genes linked to Poor social interactions, and the rest of your genome, with one test.
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Get my Genome Test71 genes linked to Poor social interactions
Changes in these genes cause rare conditions in which Poor social interactions is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| FOXG1forkhead box G1 | Always | In 1 condition |
| LINGO1leucine rich repeat and Ig domain containing 1 | Always | In 1 condition |
| MBD5methyl-CpG binding domain protein 5 | Always | In 1 condition |
| TET3tet methylcytosine dioxygenase 3 | Always | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Very often (80–99%) | In 2 conditions |
| ALG11ALG11 alpha-1,2-mannosyltransferase | Very often (80–99%) | In 1 condition |
| NF1neurofibromin 1 | Very often (80–99%) | In 1 condition |
| POLA1DNA polymerase alpha 1, catalytic subunit | Very often (80–99%) | In 1 condition |
| SH2B1SH2B adaptor protein 1 | Very often (80–99%) | In 2 conditions |
| CDKL5cyclin dependent kinase like 5 | Often (30–79%) | In 1 condition |
| CHD8chromodomain helicase DNA binding protein 8 | Often (30–79%) | In 1 condition |
| CHMP1Acharged multivesicular body protein 1A | Often (30–79%) | In 1 condition |
| CREBBPCREB binding lysine acetyltransferase | Often (30–79%) | In 2 conditions |
| EP300EP300 lysine acetyltransferase | Often (30–79%) | In 1 condition |
| GABBR2gamma-aminobutyric acid type B receptor subunit 2 | Often (30–79%) | In 1 condition |
| GRIK2glutamate ionotropic receptor kainate type subunit 2 | Often (30–79%) | In 1 condition |
| GRIN1glutamate ionotropic receptor NMDA type subunit 1 | Often (30–79%) | In 1 condition |
| IQSEC2IQ motif and Sec7 domain ArfGEF 2 | Often (30–79%) | In 1 condition |
| MAN2C1mannosidase alpha class 2C member 1 | Often (30–79%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Often (30–79%) | In 1 condition |
| NTNG1netrin G1 | Often (30–79%) | In 1 condition |
| OPHN1oligophrenin 1 | Often (30–79%) | In 1 condition |
| PLA2G6phospholipase A2 group VI | Often (30–79%) | In 1 condition |
| POGZpogo transposable element derived with ZNF domain | Often (30–79%) | In 1 condition |
| PUS3pseudouridine synthase 3 | Often (30–79%) | In 1 condition |
| SHANK3SH3 and multiple ankyrin repeat domains 3 | Often (30–79%) | In 1 condition |
| SMC1Astructural maintenance of chromosomes 1A | Often (30–79%) | In 1 condition |
| ZMYND11zinc finger MYND-type containing 11 | Often (30–79%) | In 1 condition |
| AARS1alanyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| AP2M1adaptor related protein complex 2 subunit mu 1 | Sometimes (5–29%) | In 1 condition |
| CARS1cysteinyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| CHD2chromodomain helicase DNA binding protein 2 | Sometimes (5–29%) | In 1 condition |
| CLTCclathrin heavy chain | Sometimes (5–29%) | In 1 condition |
| DBR1debranching RNA lariats 1 | Sometimes (5–29%) | In 1 condition |
| DLK1delta like non-canonical Notch ligand 1 | Sometimes (5–29%) | In 1 condition |
| DNAJC6DnaJ heat shock protein family (Hsp40) member C6 | Sometimes (5–29%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| GTF2E2general transcription factor IIE subunit 2 | Sometimes (5–29%) | In 1 condition |
| GTF2H5general transcription factor IIH subunit 5 | Sometimes (5–29%) | In 1 condition |
Show 31 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | Sometimes (5–29%) | In 1 condition |
| HTRA2HtrA serine peptidase 2 | Sometimes (5–29%) | In 1 condition |
| LRRK2leucine rich repeat kinase 2 | Sometimes (5–29%) | In 1 condition |
| MEG3maternally expressed 3 | Sometimes (5–29%) | In 1 condition |
| MPLKIPM-phase specific PLK1 interacting protein | Sometimes (5–29%) | In 1 condition |
| NEXMIFneurite extension and migration factor | Sometimes (5–29%) | In 2 conditions |
| PARK7Parkinsonism associated deglycase | Sometimes (5–29%) | In 1 condition |
| PINK1PTEN induced kinase 1 | Sometimes (5–29%) | In 1 condition |
| PODXLpodocalyxin like | Sometimes (5–29%) | In 1 condition |
| PRKNparkin RBR E3 ubiquitin protein ligase | Sometimes (5–29%) | In 1 condition |
| RNF113Aring finger protein 113A | Sometimes (5–29%) | In 1 condition |
| RTL1retrotransposon Gag like 1 | Sometimes (5–29%) | In 1 condition |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Sometimes (5–29%) | In 1 condition |
| SLC2A1solute carrier family 2 member 1 | Sometimes (5–29%) | In 1 condition |
| SLC6A1solute carrier family 6 member 1 | Sometimes (5–29%) | In 1 condition |
| SNCAsynuclein alpha | Sometimes (5–29%) | In 1 condition |
| SNRPNsmall nuclear ribonucleoprotein polypeptide N | Sometimes (5–29%) | In 1 condition |
| SYNGAP1synaptic Ras GTPase activating protein 1 | Sometimes (5–29%) | In 2 conditions |
| SYNJ1synaptojanin 1 | Sometimes (5–29%) | In 1 condition |
| TARS1threonyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| TTC19tetratricopeptide repeat domain 19 | Sometimes (5–29%) | In 1 condition |
| TUBB3tubulin beta 3 class III | Sometimes (5–29%) | In 1 condition |
| UCHL1ubiquitin C-terminal hydrolase L1 | Sometimes (5–29%) | In 1 condition |
| VPS13Cvacuolar protein sorting 13 homolog C | Sometimes (5–29%) | In 1 condition |
| WARS2tryptophanyl tRNA synthetase 2, mitochondrial | Sometimes (5–29%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| CNTNAP2contactin associated protein 2 | Not recorded | In 1 condition |
| MED12mediator complex subunit 12 | Not recorded | In 1 condition |
| NLGN1neuroligin 1 | Not recorded | In 1 condition |
| SLC6A8solute carrier family 6 member 8 | Not recorded | In 1 condition |
| TBR1T-box brain transcription factor 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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