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Trait

Bile duct proliferation

Proliferative changes of the bile ducts.

HPO HP:0001408

Summary

Also called
Proliferation of bile canaliculi
Body system
Abnormality of the digestive system

24 genes linked to Bile duct proliferation

Changes in these genes cause rare conditions in which Bile duct proliferation is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ABCB4ATP binding cassette subfamily B member 4AlwaysIn 2 conditions
CYP7B1cytochrome P450 family 7 subfamily B member 1AlwaysIn 2 conditions
FARSBphenylalanyl-tRNA synthetase subunit betaAlwaysIn 1 condition
MICOS13mitochondrial contact site and cristae organizing system subunit 13AlwaysIn 1 condition
PSKH1protein serine kinase H1AlwaysIn 1 condition
RPGRIP1LRPGRIP1 likeAlwaysIn 1 condition
SLC37A4solute carrier family 37 member 4AlwaysIn 1 condition
KIF12kinesin family member 12Very often (80–99%)In 1 condition
TMEM216transmembrane protein 216Very often (80–99%)In 1 condition
ABCB11ATP binding cassette subfamily B member 11Often (30–79%)In 1 condition
ATP8B1ATPase phospholipid transporting 8B1Often (30–79%)In 1 condition
CLDN1claudin 1Often (30–79%)In 1 condition
DCDC2doublecortin domain containing 2Often (30–79%)In 2 conditions
PHKG2phosphorylase kinase catalytic subunit gamma 2Often (30–79%)In 1 condition
POLGDNA polymerase gamma, catalytic subunitOften (30–79%)In 1 condition
TMEM67transmembrane protein 67Often (30–79%)In 2 conditions
HSD17B4hydroxysteroid 17-beta dehydrogenase 4Sometimes (5–29%)In 1 condition
IFT56intraflagellar transport 56Sometimes (5–29%)In 1 condition
MED12mediator complex subunit 12Sometimes (5–29%)In 1 condition
CC2D2Acoiled-coil and C2 domain containing 2ANot recordedIn 1 condition
CEP290centrosomal protein 290Not recordedIn 1 condition
MKS1MKS transition zone complex subunit 1Not recordedIn 1 condition
NPHP3nephrocystin 3Not recordedIn 2 conditions
WDR35WD repeat domain 35Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal biliary tract morphology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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