Trait
Slender build
Asthenic habitus refers to a slender build with long limbs, an angular profile, and prominent muscles or bones.
Summary
- Also called
- Thin build, Asthenic habitus, Thin body habitus
- Body system
- Growth abnormality
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test29 genes linked to Slender build
Changes in these genes cause rare conditions in which Slender build is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| NONOnon-POU domain containing octamer binding | Always | In 2 conditions |
| RNU2-2RNA, U2 small nuclear 2 | Always | In 1 condition |
| FBN2fibrillin 2 | Very often (80–99%) | In 1 condition |
| NSDHLNAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL | Very often (80–99%) | In 2 conditions |
| POLR3ARNA polymerase III subunit A | Very often (80–99%) | In 1 condition |
| TIMM50translocase of inner mitochondrial membrane 50 | Very often (80–99%) | In 1 condition |
| WRNWRN RecQ like helicase | Very often (80–99%) | In 1 condition |
| DNA2DNA replication helicase/nuclease 2 | Often (30–79%) | In 2 conditions |
| GRIA3glutamate ionotropic receptor AMPA type subunit 3 | Often (30–79%) | In 2 conditions |
| HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | Often (30–79%) | In 1 condition |
| MED12mediator complex subunit 12 | Often (30–79%) | In 1 condition |
| SARS1seryl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| TNNT1troponin T1, slow skeletal type | Often (30–79%) | In 1 condition |
| UPF3BUPF3B regulator of nonsense mediated mRNA decay | Often (30–79%) | In 1 condition |
| ACTA1actin alpha 1, skeletal muscle | Sometimes (5–29%) | In 2 conditions |
| CICcapicua transcriptional repressor | Sometimes (5–29%) | In 1 condition |
| KBTBD13kelch repeat and BTB domain containing 13 | Sometimes (5–29%) | In 1 condition |
| KLHL41kelch like family member 41 | Sometimes (5–29%) | In 1 condition |
| MYPNmyopalladin | Sometimes (5–29%) | In 1 condition |
| NEBnebulin | Sometimes (5–29%) | In 3 conditions |
| TGFB1transforming growth factor beta 1 | Sometimes (5–29%) | In 2 conditions |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 1 condition |
| TPM3tropomyosin 3 | Sometimes (5–29%) | In 1 condition |
| COL6A1collagen type VI alpha 1 chain | Not recorded | In 1 condition |
| FARSBphenylalanyl-tRNA synthetase subunit beta | Not recorded | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Not recorded | In 2 conditions |
| STRADASTE20 related adaptor alpha | Not recorded | In 1 condition |
| TUBB4Atubulin beta 4A class IVa | Not recorded | In 1 condition |
| TYMPthymidine phosphorylase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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