Trait
High blood bilirubin levels
Clinical name: Hyperbilirubinemia
An increased amount of bilirubin in the blood.
Summary
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
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Read the genes linked to High blood bilirubin levels, and the rest of your genome, with one test.
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Get my Genome Test73 genes linked to High blood bilirubin levels
Changes in these genes cause rare conditions in which High blood bilirubin levels is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCD3ATP binding cassette subfamily D member 3 | Always | In 1 condition |
| ADKadenosine kinase | Always | In 1 condition |
| ALDOAaldolase, fructose-bisphosphate A | Always | In 1 condition |
| AMACRalpha-methylacyl-CoA racemase | Always | In 1 condition |
| ANK1ankyrin 1 | Always | In 2 conditions |
| ATP7BATPase copper transporting beta | Always | In 1 condition |
| CDAN1codanin 1 | Always | In 1 condition |
| CHASERRCHD2 adjacent suppressive regulatory RNA | Always | In 1 condition |
| CYP7B1cytochrome P450 family 7 subfamily B member 1 | Always | In 2 conditions |
| GATA1GATA binding protein 1 | Always | In 1 condition |
| GLI2GLI family zinc finger 2 | Always | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Always | In 1 condition |
| NT5C3A5'-nucleotidase, cytosolic IIIA | Always | In 1 condition |
| ODC1ornithine decarboxylase 1 | Always | In 1 condition |
| PEX1peroxisomal biogenesis factor 1 | Always | In 1 condition |
| PEX19peroxisomal biogenesis factor 19 | Always | In 1 condition |
| RNU6ATACRNA, U6atac small nuclear | Always | In 1 condition |
| SC5Dsterol-C5-desaturase | Always | In 1 condition |
| SLC19A1solute carrier family 19 member 1 | Always | In 1 condition |
| SLC25A13solute carrier family 25 member 13 | Always | In 2 conditions |
| SPTBspectrin beta, erythrocytic | Always | In 3 conditions |
| TMEM63Btransmembrane protein 63B | Always | In 1 condition |
| VPS33BVPS33B late endosome and lysosome associated | Always | In 1 condition |
| VPS50VPS50 subunit of EARP/GARPII complex | Always | In 1 condition |
| AKR1D1aldo-keto reductase family 1 member D1 | Very often (80–99%) | In 2 conditions |
| TRMUtRNA mitochondrial 2-thiouridylase | Very often (80–99%) | In 1 condition |
| CHD8chromodomain helicase DNA binding protein 8 | Often (30–79%) | In 1 condition |
| EPB42erythrocyte membrane protein band 4.2 | Often (30–79%) | In 1 condition |
| FOCADfocadhesin | Often (30–79%) | In 1 condition |
| HMBShydroxymethylbilane synthase | Often (30–79%) | In 1 condition |
| KIF23kinesin family member 23 | Often (30–79%) | In 1 condition |
| KLF1KLF transcription factor 1 | Often (30–79%) | In 1 condition |
| MTTPmicrosomal triglyceride transfer protein | Often (30–79%) | In 1 condition |
| NEK8NIMA related kinase 8 | Often (30–79%) | In 1 condition |
| NPHP3nephrocystin 3 | Often (30–79%) | In 1 condition |
| OTX2orthodenticle homeobox 2 | Often (30–79%) | In 1 condition |
| PGK1phosphoglycerate kinase 1 | Often (30–79%) | In 1 condition |
| RACGAP1Rac GTPase activating protein 1 | Often (30–79%) | In 1 condition |
| RHAGRh associated glycoprotein | Often (30–79%) | In 2 conditions |
| RHCERh blood group CcEe antigens | Often (30–79%) | In 2 conditions |
Show 33 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| RHDRh blood group D antigen | Often (30–79%) | In 1 condition |
| SLC2A2solute carrier family 2 member 2 | Often (30–79%) | In 1 condition |
| SLC4A1solute carrier family 4 member 1 (Diego blood group) | Often (30–79%) | In 2 conditions |
| SLCO1B1solute carrier organic anion transporter family member 1B1 | Often (30–79%) | In 1 condition |
| SLCO1B3solute carrier organic anion transporter family member 1B3 | Often (30–79%) | In 1 condition |
| SPTA1spectrin alpha, erythrocytic 1 | Often (30–79%) | In 2 conditions |
| TFAMtranscription factor A, mitochondrial | Often (30–79%) | In 1 condition |
| ABCB11ATP binding cassette subfamily B member 11 | Sometimes (5–29%) | In 1 condition |
| ABCB4ATP binding cassette subfamily B member 4 | Sometimes (5–29%) | In 1 condition |
| ATP8B1ATPase phospholipid transporting 8B1 | Sometimes (5–29%) | In 1 condition |
| EIF2AK3eukaryotic translation initiation factor 2 alpha kinase 3 | Sometimes (5–29%) | In 1 condition |
| EPB41erythrocyte membrane protein band 4.1 | Sometimes (5–29%) | In 1 condition |
| GYPCglycophorin C (Gerbich blood group) | Sometimes (5–29%) | In 1 condition |
| IFT56intraflagellar transport 56 | Sometimes (5–29%) | In 1 condition |
| MED12mediator complex subunit 12 | Sometimes (5–29%) | In 1 condition |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Sometimes (5–29%) | In 1 condition |
| NR1H4nuclear receptor subfamily 1 group H member 4 | Sometimes (5–29%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Sometimes (5–29%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Sometimes (5–29%) | In 1 condition |
| TCEAL1transcription elongation factor A like 1 | Sometimes (5–29%) | In 1 condition |
| ZNF699zinc finger protein 699 | Sometimes (5–29%) | In 1 condition |
| ALDOBaldolase, fructose-bisphosphate B | Not recorded | In 1 condition |
| DGUOKdeoxyguanosine kinase | Not recorded | In 1 condition |
| FHfumarate hydratase | Not recorded | In 1 condition |
| GSRglutathione-disulfide reductase | Not recorded | In 1 condition |
| HK1hexokinase 1 | Not recorded | In 1 condition |
| KCNN4potassium calcium-activated channel subfamily N member 4 | Not recorded | In 1 condition |
| LBRlamin B receptor | Not recorded | In 1 condition |
| OSTM1osteoclastogenesis associated transmembrane protein 1 | Not recorded | In 1 condition |
| PAX8paired box 8 | Not recorded | In 1 condition |
| POMCproopiomelanocortin | Not recorded | In 1 condition |
| RFX6regulatory factor X6 | Not recorded | In 1 condition |
| WDR35WD repeat domain 35 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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