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Trait

Facial wrinkling

Excessive wrinkling of the skin of the face.

HPO HP:0009762

Summary

Body system
Abnormality of the integument

3 genes linked to Facial wrinkling

Changes in these genes cause rare conditions in which Facial wrinkling is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
CAV1caveolin 1Often (30–79%)In 1 condition
MED12mediator complex subunit 12Sometimes (5–29%)In 2 conditions
NAA10N-alpha-acetyltransferase 10, NatA catalytic subunitNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Premature skin wrinkling

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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