Trait
Decreased liver function
Reduced ability of the liver to perform its functions.
Summary
- Also called
- Liver dysfunction, Liver dysfunction, mild
- Body system
- Abnormality of the digestive system
Reference genomeGRCh38hg38
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Get my Genome Test74 genes linked to Decreased liver function
Changes in these genes cause rare conditions in which Decreased liver function is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATP6AP2ATPase H+ transporting accessory protein 2 | Always | In 1 condition |
| BCS1LBCS1 ubiquinol-cytochrome c reductase complex chaperone | Always | In 1 condition |
| DDOSTdolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit | Always | In 1 condition |
| FADDFas associated via death domain | Always | In 1 condition |
| FARSBphenylalanyl-tRNA synthetase subunit beta | Always | In 1 condition |
| GCSHglycine cleavage system protein H | Always | In 1 condition |
| LARS2leucyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| MED12mediator complex subunit 12 | Always | In 1 condition |
| MICOS13mitochondrial contact site and cristae organizing system subunit 13 | Always | In 1 condition |
| MRPS23mitochondrial ribosomal protein S23 | Always | In 1 condition |
| VPS51VPS51 subunit of GARP complex | Always | In 1 condition |
| ACADMacyl-CoA dehydrogenase medium chain | Often (30–79%) | In 1 condition |
| ALG3ALG3 alpha-1,3- mannosyltransferase | Often (30–79%) | In 1 condition |
| ALG8ALG8 alpha-1,3-glucosyltransferase | Often (30–79%) | In 1 condition |
| BTNL2butyrophilin like 2 | Often (30–79%) | In 1 condition |
| COA8cytochrome c oxidase assembly factor 8 | Often (30–79%) | In 1 condition |
| COG2component of oligomeric golgi complex 2 | Often (30–79%) | In 1 condition |
| GATCglutamyl-tRNA amidotransferase subunit C | Often (30–79%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Often (30–79%) | In 1 condition |
| LRPPRCleucine rich pentatricopeptide repeat containing | Often (30–79%) | In 1 condition |
| LYSTlysosomal trafficking regulator | Often (30–79%) | In 1 condition |
| MPImannose phosphate isomerase | Often (30–79%) | In 1 condition |
| PRF1perforin 1 | Often (30–79%) | In 1 condition |
| QRSL1glutaminyl-tRNA amidotransferase subunit QRSL1 | Often (30–79%) | In 1 condition |
| SLC25A15solute carrier family 25 member 15 | Often (30–79%) | In 2 conditions |
| SMPD1sphingomyelin phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| STX11syntaxin 11 | Often (30–79%) | In 1 condition |
| STXBP2syntaxin binding protein 2 | Often (30–79%) | In 1 condition |
| UNC13Dunc-13 homolog D | Often (30–79%) | In 1 condition |
| ALG1ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase | Sometimes (5–29%) | In 1 condition |
| ASXL1ASXL transcriptional regulator 1 | Sometimes (5–29%) | In 1 condition |
| CBLCbl proto-oncogene | Sometimes (5–29%) | In 1 condition |
| DLDdihydrolipoamide dehydrogenase | Sometimes (5–29%) | In 1 condition |
| FECHferrochelatase | Sometimes (5–29%) | In 1 condition |
| GALMgalactose mutarotase | Sometimes (5–29%) | In 1 condition |
| GANABglucosidase II alpha subunit | Sometimes (5–29%) | In 1 condition |
| HBBhemoglobin subunit beta | Sometimes (5–29%) | In 1 condition |
| PCK1phosphoenolpyruvate carboxykinase 1 | Sometimes (5–29%) | In 1 condition |
| PCK2phosphoenolpyruvate carboxykinase 2, mitochondrial | Sometimes (5–29%) | In 1 condition |
| RNU12RNA, U12 small nuclear | Sometimes (5–29%) | In 1 condition |
Show 34 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| RUNX1RUNX family transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 1 condition |
| SRSF2serine and arginine rich splicing factor 2 | Sometimes (5–29%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Sometimes (5–29%) | In 1 condition |
| PARS2prolyl-tRNA synthetase 2, mitochondrial | Rarely (1–4%) | In 1 condition |
| BLVRAbiliverdin reductase A | Not recorded | In 1 condition |
| CCDC47coiled-coil domain containing 47 | Not recorded | In 1 condition |
| COG7component of oligomeric golgi complex 7 | Not recorded | In 1 condition |
| COX10cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 | Not recorded | In 1 condition |
| COX15cytochrome c oxidase assembly factor COX15 | Not recorded | In 1 condition |
| COX6B1cytochrome c oxidase subunit 6B1 | Not recorded | In 1 condition |
| FASTKD2FASTK mitochondrial RNA regulator 2 | Not recorded | In 1 condition |
| GALTgalactose-1-phosphate uridylyltransferase | Not recorded | In 1 condition |
| IARS1isoleucyl-tRNA synthetase 1 | Not recorded | In 1 condition |
| LIPT1lipoyltransferase 1 | Not recorded | In 1 condition |
| MT-TNmitochondrially encoded tRNA-Asn (AAU/C) | Not recorded | In 1 condition |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Not recorded | In 1 condition |
| OCLNoccludin | Not recorded | In 1 condition |
| PEX10peroxisomal biogenesis factor 10 | Not recorded | In 2 conditions |
| PEX13peroxisomal biogenesis factor 13 | Not recorded | In 1 condition |
| PEX16peroxisomal biogenesis factor 16 | Not recorded | In 1 condition |
| PEX2peroxisomal biogenesis factor 2 | Not recorded | In 1 condition |
| PEX26peroxisomal biogenesis factor 26 | Not recorded | In 1 condition |
| PEX6peroxisomal biogenesis factor 6 | Not recorded | In 1 condition |
| RMND1required for meiotic nuclear division 1 homolog | Not recorded | In 1 condition |
| SCO1synthesis of cytochrome C oxidase 1 | Not recorded | In 1 condition |
| SCO2synthesis of cytochrome C oxidase 2 | Not recorded | In 1 condition |
| SLC30A10solute carrier family 30 member 10 | Not recorded | In 1 condition |
| SURF1SURF1 cytochrome c oxidase assembly factor | Not recorded | In 1 condition |
| TACO1translational activator of cytochrome c oxidase I | Not recorded | In 1 condition |
| TALDO1transaldolase 1 | Not recorded | In 1 condition |
| TRMT10CtRNA methyltransferase 10C, mitochondrial RNase P subunit | Not recorded | In 1 condition |
| UQCRC2ubiquinol-cytochrome c reductase core protein 2 | Not recorded | In 1 condition |
| VMA12vacuolar ATPase assembly factor VMA12 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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