Trait
Prominent nose
Distance between subnasale and pronasale more than two standard deviations above the mean, or alternatively, an apparently increased anterior protrusion of the nasal tip.
Summary
- Also called
- Big nose, Disproportionately large nose, Increased nasal size, Increased size of nose, Large nose, Pronounced nose
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Prominent nose, and the rest of your genome, with one test.
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Get my Genome Test125 genes linked to Prominent nose
Changes in these genes cause rare conditions in which Prominent nose is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACER3alkaline ceramidase 3 | Always | In 1 condition |
| APC2APC regulator of Wnt signaling pathway 2 | Always | In 1 condition |
| ASH1LASH1 like histone lysine methyltransferase | Always | In 1 condition |
| ASPHaspartate beta-hydroxylase | Always | In 1 condition |
| CDK19cyclin dependent kinase 19 | Always | In 1 condition |
| CDK5RAP2CDK5 regulatory subunit associated protein 2 | Always | In 1 condition |
| DENND5ADENN domain containing 5A | Always | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Always | In 1 condition |
| ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Always | In 1 condition |
| FBXL3F-box and leucine rich repeat protein 3 | Always | In 1 condition |
| FEM1Bfem-1 homolog B | Always | In 1 condition |
| GMPPAGDP-mannose pyrophosphorylase A | Always | In 1 condition |
| HIVEP2HIVEP zinc finger 2 | Always | In 1 condition |
| INPP4Ainositol polyphosphate-4-phosphatase type I A | Always | In 1 condition |
| INTUinturned planar cell polarity protein | Always | In 1 condition |
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Always | In 1 condition |
| LIG4DNA ligase 4 | Always | In 1 condition |
| MAU2MAU2 sister chromatid cohesion factor | Always | In 1 condition |
| NAV3neuron navigator 3 | Always | In 1 condition |
| NBNnibrin | Always | In 2 conditions |
| NHSNHS actin remodeling regulator | Always | In 2 conditions |
| NINninein | Always | In 2 conditions |
| NONOnon-POU domain containing octamer binding | Always | In 2 conditions |
| PEX19peroxisomal biogenesis factor 19 | Always | In 1 condition |
| QRICH1glutamine rich 1 | Always | In 1 condition |
| RBSNrabenosyn, RAB effector | Always | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Always | In 3 conditions |
| SRCAPSnf2 related CREBBP activator protein | Always | In 1 condition |
| STILSTIL centriolar assembly protein | Always | In 1 condition |
| STIM1stromal interaction molecule 1 | Always | In 1 condition |
| TAF4TATA-box binding protein associated factor 4 | Always | In 1 condition |
| TAF6TATA-box binding protein associated factor 6 | Always | In 1 condition |
| UGGT1UDP-glucose glycoprotein glucosyltransferase 1 | Always | In 1 condition |
| ZNF668zinc finger protein 668 | Always | In 1 condition |
| CUL4Bcullin 4B | Very often (80–99%) | In 1 condition |
| EMG1EMG1 N1-specific pseudouridine methyltransferase | Very often (80–99%) | In 2 conditions |
| GINS3GINS complex subunit 3 | Very often (80–99%) | In 1 condition |
| HYMAIhydatidiform mole associated and imprinted | Very often (80–99%) | In 1 condition |
| KAT6Blysine acetyltransferase 6B | Very often (80–99%) | In 3 conditions |
| PCNTpericentrin | Very often (80–99%) | In 2 conditions |
Show 85 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| PLAGL1PLAG1 like zinc finger 1 | Very often (80–99%) | In 1 condition |
| AARS1alanyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| ACTBactin beta | Often (30–79%) | In 1 condition |
| ACTG1actin gamma 1 | Often (30–79%) | In 1 condition |
| BCL11BBCL11 transcription factor B | Often (30–79%) | In 1 condition |
| BPTFbromodomain PHD finger transcription factor | Often (30–79%) | In 1 condition |
| CENPEcentromere protein E | Often (30–79%) | In 1 condition |
| CENPTcentromere protein T | Often (30–79%) | In 1 condition |
| COG5component of oligomeric golgi complex 5 | Often (30–79%) | In 1 condition |
| CTSKcathepsin K | Often (30–79%) | In 2 conditions |
| EP300EP300 lysine acetyltransferase | Often (30–79%) | In 2 conditions |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Often (30–79%) | In 1 condition |
| EXOSC5exosome component 5 | Often (30–79%) | In 1 condition |
| FGF3fibroblast growth factor 3 | Often (30–79%) | In 2 conditions |
| LMBR1limb development membrane protein 1 | Often (30–79%) | In 1 condition |
| MAN1B1mannosidase alpha class 1B member 1 | Often (30–79%) | In 2 conditions |
| MED12mediator complex subunit 12 | Often (30–79%) | In 4 conditions |
| NFIXnuclear factor I X | Often (30–79%) | In 1 condition |
| PMM2phosphomannomutase 2 | Often (30–79%) | In 1 condition |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Often (30–79%) | In 1 condition |
| PTPMT1protein tyrosine phosphatase mitochondrial 1 | Often (30–79%) | In 1 condition |
| PUM1pumilio RNA binding family member 1 | Often (30–79%) | In 1 condition |
| RUSC2RUN and SH3 domain containing 2 | Often (30–79%) | In 1 condition |
| SLC6A1solute carrier family 6 member 1 | Often (30–79%) | In 1 condition |
| SLC6A11solute carrier family 6 member 11 | Often (30–79%) | In 1 condition |
| WARS1tryptophanyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| ADAT3adenosine deaminase tRNA specific 3 | Sometimes (5–29%) | In 1 condition |
| CLTCL1clathrin heavy chain like 1 | Sometimes (5–29%) | In 1 condition |
| COG3component of oligomeric golgi complex 3 | Sometimes (5–29%) | In 1 condition |
| CREBBPCREB binding lysine acetyltransferase | Sometimes (5–29%) | In 1 condition |
| DCAF17DDB1 and CUL4 associated factor 17 | Sometimes (5–29%) | In 1 condition |
| EBF3EBF transcription factor 3 | Sometimes (5–29%) | In 1 condition |
| EXTL3exostosin like glycosyltransferase 3 | Sometimes (5–29%) | In 1 condition |
| FBXO11F-box protein 11 | Sometimes (5–29%) | In 1 condition |
| FILIP1filamin A interacting protein 1 | Sometimes (5–29%) | In 1 condition |
| FOXP2forkhead box P2 | Sometimes (5–29%) | In 1 condition |
| GNB2G protein subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| H4C5H4 clustered histone 5 | Sometimes (5–29%) | In 1 condition |
| HNRNPCheterogeneous nuclear ribonucleoprotein C | Sometimes (5–29%) | In 1 condition |
| MARK2microtubule affinity regulating kinase 2 | Sometimes (5–29%) | In 1 condition |
| MINPP1multiple inositol-polyphosphate phosphatase 1 | Sometimes (5–29%) | In 1 condition |
| OPHN1oligophrenin 1 | Sometimes (5–29%) | In 2 conditions |
| PDE4Dphosphodiesterase 4D | Sometimes (5–29%) | In 1 condition |
| PGM2L1phosphoglucomutase 2 like 1 | Sometimes (5–29%) | In 1 condition |
| PLAAT3phospholipase A and acyltransferase 3 | Sometimes (5–29%) | In 1 condition |
| PLK4polo like kinase 4 | Sometimes (5–29%) | In 1 condition |
| SLF2SMC5/6 complex localization factor 2 | Sometimes (5–29%) | In 1 condition |
| SMC5structural maintenance of chromosomes 5 | Sometimes (5–29%) | In 1 condition |
| SMG8SMG8 nonsense mediated mRNA decay factor | Sometimes (5–29%) | In 1 condition |
| SNRPNsmall nuclear ribonucleoprotein polypeptide N | Sometimes (5–29%) | In 1 condition |
| SOX6SRY-box transcription factor 6 | Sometimes (5–29%) | In 1 condition |
| SPARTspartin | Sometimes (5–29%) | In 1 condition |
| SPOPspeckle type BTB/POZ protein | Sometimes (5–29%) | In 1 condition |
| TBC1D32TBC1 domain family member 32 | Sometimes (5–29%) | In 1 condition |
| TMEM94transmembrane protein 94 | Sometimes (5–29%) | In 1 condition |
| TTC5tetratricopeptide repeat domain 5 | Sometimes (5–29%) | In 1 condition |
| TTI2TELO2 interacting protein 2 | Sometimes (5–29%) | In 2 conditions |
| UFC1ubiquitin-fold modifier conjugating enzyme 1 | Sometimes (5–29%) | In 1 condition |
| USP9Xubiquitin specific peptidase 9 X-linked | Sometimes (5–29%) | In 2 conditions |
| ZNF699zinc finger protein 699 | Sometimes (5–29%) | In 1 condition |
| GJA5gap junction protein alpha 5 | Rarely (1–4%) | In 1 condition |
| GJA8gap junction protein alpha 8 | Rarely (1–4%) | In 1 condition |
| PTBP1polypyrimidine tract binding protein 1 | Rarely (1–4%) | In 1 condition |
| AP1S2adaptor related protein complex 1 subunit sigma 2 | Not recorded | In 1 condition |
| AP4S1adaptor related protein complex 4 subunit sigma 1 | Not recorded | In 1 condition |
| ATRATR checkpoint kinase | Not recorded | In 1 condition |
| BLMBLM RecQ like helicase | Not recorded | In 1 condition |
| CEP120centrosomal protein 120 | Not recorded | In 1 condition |
| CHD3chromodomain helicase DNA binding protein 3 | Not recorded | In 1 condition |
| DYNC1I2dynein cytoplasmic 1 intermediate chain 2 | Not recorded | In 1 condition |
| EIF4A3eukaryotic translation initiation factor 4A3 | Not recorded | In 1 condition |
| FHL1four and a half LIM domains 1 | Not recorded | In 1 condition |
| GPC4glypican 4 | Not recorded | In 1 condition |
| ITGA3integrin subunit alpha 3 | Not recorded | In 1 condition |
| MBD5methyl-CpG binding domain protein 5 | Not recorded | In 1 condition |
| NSUN2NOP2/Sun RNA methyltransferase 2 | Not recorded | In 1 condition |
| PEX3peroxisomal biogenesis factor 3 | Not recorded | In 1 condition |
| POC1APOC1 centriolar protein A | Not recorded | In 1 condition |
| PSMB8proteasome 20S subunit beta 8 | Not recorded | In 1 condition |
| RBBP8RB binding protein 8, endonuclease | Not recorded | In 2 conditions |
| RLIMring finger protein, LIM domain interacting | Not recorded | In 1 condition |
| STAG2STAG2 cohesin complex component | Not recorded | In 1 condition |
| UNC80unc-80 subunit of NALCN channel complex | Not recorded | In 1 condition |
| WDR73WD repeat domain 73 | Not recorded | In 1 condition |
| WNK3WNK lysine deficient protein kinase 3 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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