Trait
Low frustration tolerance
The feeling of frustration can be defined as an emotional reaction that occurs when a desired goal is not achieved. Frustration intolerance is defined as an age-inappropriate response to frustration, characterized by crying or temper tantrums in children, or aggressive or other maladaptive behaviors.
Summary
- Also called
- Intolerance to frustration
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test28 genes linked to Low frustration tolerance
Changes in these genes cause rare conditions in which Low frustration tolerance is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CACHD1cache domain containing 1 | Always | In 1 condition |
| FAM177A1family with sequence similarity 177 member A1 | Always | In 1 condition |
| FEM1Bfem-1 homolog B | Always | In 1 condition |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| KMT2Alysine methyltransferase 2A | Often (30–79%) | In 1 condition |
| POGZpogo transposable element derived with ZNF domain | Often (30–79%) | In 1 condition |
| PPP2R5Dprotein phosphatase 2 regulatory subunit B'delta | Often (30–79%) | In 1 condition |
| RNU5B-1RNA, U5B small nuclear 1 | Often (30–79%) | In 1 condition |
| CNTNAP2contactin associated protein 2 | Sometimes (5–29%) | In 1 condition |
| DNAJC13DnaJ heat shock protein family (Hsp40) member C13 | Sometimes (5–29%) | In 1 condition |
| EIF4G1eukaryotic translation initiation factor 4 gamma 1 | Sometimes (5–29%) | In 1 condition |
| GATAD2BGATA zinc finger domain containing 2B | Sometimes (5–29%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Sometimes (5–29%) | In 1 condition |
| GIGYF2GRB10 interacting GYF protein 2 | Sometimes (5–29%) | In 1 condition |
| GNB2G protein subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| LRRK2leucine rich repeat kinase 2 | Sometimes (5–29%) | In 1 condition |
| NAV3neuron navigator 3 | Sometimes (5–29%) | In 1 condition |
| OPHN1oligophrenin 1 | Sometimes (5–29%) | In 1 condition |
| PUF60poly(U) binding splicing factor 60 | Sometimes (5–29%) | In 1 condition |
| SGSM3small G protein signaling modulator 3 | Sometimes (5–29%) | In 1 condition |
| SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | Sometimes (5–29%) | In 1 condition |
| SNCAsynuclein alpha | Sometimes (5–29%) | In 1 condition |
| TRA2Btransformer 2 beta homolog | Sometimes (5–29%) | In 1 condition |
| VPS35VPS35 retromer complex component | Sometimes (5–29%) | In 1 condition |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| KDM5Clysine demethylase 5C | Not recorded | In 1 condition |
| MAOAmonoamine oxidase A | Not recorded | In 1 condition |
| MED12mediator complex subunit 12 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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