Trait
Narrow face
Bizygomatic (upper face) and bigonial (lower face) width are both more than 2 standard deviations below the mean (objective); or, an apparent reduction in the width of the upper and lower face (subjective).
Summary
- Also called
- Decreased breadth of face, Decreased width of face, Thin face, Decreased horizontal dimension of face, Decreased transverse dimension of face, Horizontal deficiency of face, Horizontal hypoplasia of face, Horizontal insufficiency of face, Narrow facies, Thin facies, Transverse deficiency of face, Transverse hypoplasia of face, Transverse insufficiency of face
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test114 genes linked to Narrow face
Changes in these genes cause rare conditions in which Narrow face is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| COL18A1collagen type XVIII alpha 1 chain | Always | In 1 condition |
| EFEMP1EGF-like fibulin extracellular matrix protein 1 | Always | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Always | In 1 condition |
| EYA1EYA transcriptional coactivator and phosphatase 1 | Always | In 2 conditions |
| HYOU1hypoxia up-regulated 1 | Always | In 1 condition |
| MAP2K2mitogen-activated protein kinase kinase 2 | Always | In 1 condition |
| MED12mediator complex subunit 12 | Always | In 2 conditions |
| MICU1mitochondrial calcium uptake 1 | Always | In 1 condition |
| NHSNHS actin remodeling regulator | Always | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Always | In 2 conditions |
| RYR3ryanodine receptor 3 | Always | In 1 condition |
| SLC37A4solute carrier family 37 member 4 | Always | In 1 condition |
| TRAIPTRAF interacting protein | Always | In 2 conditions |
| TSPAN7tetraspanin 7 | Always | In 1 condition |
| ATRATR checkpoint kinase | Very often (80–99%) | In 1 condition |
| ATRIPATR interacting protein | Very often (80–99%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Very often (80–99%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Very often (80–99%) | In 1 condition |
| CENPEcentromere protein E | Very often (80–99%) | In 1 condition |
| CEP152centrosomal protein 152 | Very often (80–99%) | In 1 condition |
| CEP295centrosomal protein 295 | Very often (80–99%) | In 1 condition |
| CEP63centrosomal protein 63 | Very often (80–99%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Very often (80–99%) | In 1 condition |
| CPAPcentrosome assembly and centriole elongation protein | Very often (80–99%) | In 1 condition |
| DNA2DNA replication helicase/nuclease 2 | Very often (80–99%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Very often (80–99%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Very often (80–99%) | In 1 condition |
| ELNelastin | Very often (80–99%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Very often (80–99%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Very often (80–99%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Very often (80–99%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Very often (80–99%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Very often (80–99%) | In 1 condition |
| LMNAlamin A/C | Very often (80–99%) | In 1 condition |
| MEGF8multiple EGF like domains 8 | Very often (80–99%) | In 1 condition |
| METTL27methyltransferase like 27 | Very often (80–99%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Very often (80–99%) | In 1 condition |
| NFIXnuclear factor I X | Very often (80–99%) | In 2 conditions |
| NINninein | Very often (80–99%) | In 1 condition |
| NOTCH3notch receptor 3 | Very often (80–99%) | In 1 condition |
Show 74 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| NSDHLNAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL | Very often (80–99%) | In 2 conditions |
| NSMCE2NSE2 SUMO ligase component of SMC5/6 complex | Very often (80–99%) | In 1 condition |
| NUP85nucleoporin 85 | Very often (80–99%) | In 1 condition |
| PAX3paired box 3 | Very often (80–99%) | In 1 condition |
| PCNTpericentrin | Very often (80–99%) | In 1 condition |
| PLK4polo like kinase 4 | Very often (80–99%) | In 1 condition |
| PQBP1polyglutamine binding protein 1 | Very often (80–99%) | In 4 conditions |
| RAB23RAB23, member RAS oncogene family | Very often (80–99%) | In 1 condition |
| RBBP8RB binding protein 8, endonuclease | Very often (80–99%) | In 1 condition |
| RFC2replication factor C subunit 2 | Very often (80–99%) | In 1 condition |
| SLC9A6solute carrier family 9 member A6 | Very often (80–99%) | In 2 conditions |
| STX1Asyntaxin 1A | Very often (80–99%) | In 1 condition |
| TBL2transducin beta like 2 | Very often (80–99%) | In 1 condition |
| TMEM270transmembrane protein 270 | Very often (80–99%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Very often (80–99%) | In 1 condition |
| ACTA1actin alpha 1, skeletal muscle | Often (30–79%) | In 3 conditions |
| ANTXR2ANTXR cell adhesion molecule 2 | Often (30–79%) | In 1 condition |
| APC2APC regulator of Wnt signaling pathway 2 | Often (30–79%) | In 1 condition |
| BCORBCL6 corepressor | Often (30–79%) | In 2 conditions |
| BLMBLM RecQ like helicase | Often (30–79%) | In 2 conditions |
| CENPTcentromere protein T | Often (30–79%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Often (30–79%) | In 1 condition |
| FMR1fragile X messenger ribonucleoprotein 1 | Often (30–79%) | In 1 condition |
| MARK2microtubule affinity regulating kinase 2 | Often (30–79%) | In 1 condition |
| MYH3myosin heavy chain 3 | Often (30–79%) | In 1 condition |
| NALCNsodium leak channel, non-selective | Often (30–79%) | In 1 condition |
| SEMA3Esemaphorin 3E | Often (30–79%) | In 1 condition |
| SLC16A2solute carrier family 16 member 2 | Often (30–79%) | In 1 condition |
| SMSspermine synthase | Often (30–79%) | In 1 condition |
| STEEP1STING1 ER exit protein 1 | Often (30–79%) | In 1 condition |
| TBX1T-box transcription factor 1 | Often (30–79%) | In 1 condition |
| TNNI2troponin I2, fast skeletal type | Often (30–79%) | In 1 condition |
| TNNT3troponin T3, fast skeletal type | Often (30–79%) | In 1 condition |
| TPM2tropomyosin 2 | Often (30–79%) | In 3 conditions |
| UBE3Bubiquitin protein ligase E3B | Often (30–79%) | In 2 conditions |
| UPF3BUPF3B regulator of nonsense mediated mRNA decay | Often (30–79%) | In 2 conditions |
| WRNWRN RecQ like helicase | Often (30–79%) | In 1 condition |
| ZDHHC9zDHHC palmitoyltransferase 9 | Often (30–79%) | In 1 condition |
| BORCS8BLOC-1 related complex subunit 8 | Sometimes (5–29%) | In 1 condition |
| CFL2cofilin 2 | Sometimes (5–29%) | In 1 condition |
| HECTD4HECT domain E3 ubiquitin protein ligase 4 | Sometimes (5–29%) | In 1 condition |
| HIVEP2HIVEP zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| KBTBD13kelch repeat and BTB domain containing 13 | Sometimes (5–29%) | In 1 condition |
| KLHL41kelch like family member 41 | Sometimes (5–29%) | In 2 conditions |
| KMT2Dlysine methyltransferase 2D | Sometimes (5–29%) | In 1 condition |
| LMOD3leiomodin 3 | Sometimes (5–29%) | In 1 condition |
| MYPNmyopalladin | Sometimes (5–29%) | In 1 condition |
| NEBnebulin | Sometimes (5–29%) | In 2 conditions |
| PPP1R15Bprotein phosphatase 1 regulatory subunit 15B | Sometimes (5–29%) | In 1 condition |
| RECQL4RecQ like helicase 4 | Sometimes (5–29%) | In 1 condition |
| RFX7regulatory factor X7 | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 1 condition |
| SATB2SATB homeobox 2 | Sometimes (5–29%) | In 1 condition |
| STRADASTE20 related adaptor alpha | Sometimes (5–29%) | In 1 condition |
| TPM3tropomyosin 3 | Sometimes (5–29%) | In 3 conditions |
| TRMT10AtRNA methyltransferase 10A | Sometimes (5–29%) | In 1 condition |
| CTCFCCCTC-binding factor | Rarely (1–4%) | In 1 condition |
| AP4E1adaptor related protein complex 4 subunit epsilon 1 | Not recorded | In 1 condition |
| ATP7AATPase copper transporting alpha | Not recorded | In 1 condition |
| CHRNB1cholinergic receptor nicotinic beta 1 subunit | Not recorded | In 1 condition |
| DSTYKdual serine/threonine and tyrosine protein kinase | Not recorded | In 1 condition |
| FBN1fibrillin 1 | Not recorded | In 1 condition |
| FBXL4F-box and leucine rich repeat protein 4 | Not recorded | In 1 condition |
| MTM1myotubularin 1 | Not recorded | In 1 condition |
| NGLY1N-glycanase 1 | Not recorded | In 1 condition |
| NOGnoggin | Not recorded | In 1 condition |
| NSUN2NOP2/Sun RNA methyltransferase 2 | Not recorded | In 1 condition |
| PBX1PBX homeobox 1 | Not recorded | In 1 condition |
| RLIMring finger protein, LIM domain interacting | Not recorded | In 1 condition |
| SIN3ASIN3 transcription regulator family member A | Not recorded | In 1 condition |
| SIX1SIX homeobox 1 | Not recorded | In 1 condition |
| SLC6A8solute carrier family 6 member 8 | Not recorded | In 1 condition |
| TRIP11thyroid hormone receptor interactor 11 | Not recorded | In 1 condition |
| TUBB4Atubulin beta 4A class IVa | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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