Trait
Slowed or blocked flow of bile from liver
Clinical name: Cholestasis
Impairment of bile flow due to obstruction in bile ducts.
Summary
- Body system
- Abnormality of the digestive system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test81 genes linked to Slowed or blocked flow of bile from liver
Changes in these genes cause rare conditions in which Slowed or blocked flow of bile from liver is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCB4ATP binding cassette subfamily B member 4 | Always | In 1 condition |
| AMOTL1angiomotin like 1 | Always | In 1 condition |
| ARG1arginase 1 | Always | In 1 condition |
| ATP6AP1ATPase H+ transporting accessory protein 1 | Always | In 1 condition |
| CLDN1claudin 1 | Always | In 2 conditions |
| DCDC2doublecortin domain containing 2 | Always | In 3 conditions |
| FARSBphenylalanyl-tRNA synthetase subunit beta | Always | In 1 condition |
| GFM1G elongation factor mitochondrial 1 | Always | In 1 condition |
| JAG1jagged canonical Notch ligand 1 | Always | In 1 condition |
| KIF12kinesin family member 12 | Always | In 1 condition |
| LBRlamin B receptor | Always | In 1 condition |
| LYNLYN proto-oncogene, Src family tyrosine kinase | Always | In 1 condition |
| MARS1methionyl-tRNA synthetase 1 | Always | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Always | In 1 condition |
| POLG2DNA polymerase gamma 2, accessory subunit | Always | In 1 condition |
| PSKH1protein serine kinase H1 | Always | In 1 condition |
| SPOUT1SPOUT domain containing methyltransferase 1 | Always | In 1 condition |
| TFAMtranscription factor A, mitochondrial | Always | In 1 condition |
| UNC45Aunc-45 myosin chaperone A | Always | In 1 condition |
| USP53ubiquitin specific peptidase 53 | Always | In 1 condition |
| VPS33BVPS33B late endosome and lysosome associated | Always | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Very often (80–99%) | In 1 condition |
| BCAP31B cell receptor associated protein 31 | Very often (80–99%) | In 1 condition |
| BCS1LBCS1 ubiquinol-cytochrome c reductase complex chaperone | Very often (80–99%) | In 3 conditions |
| CYP7A1cytochrome P450 family 7 subfamily A member 1 | Very often (80–99%) | In 1 condition |
| GPR35G protein-coupled receptor 35 | Very often (80–99%) | In 1 condition |
| MST1macrophage stimulating 1 | Very often (80–99%) | In 1 condition |
| PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin | Very often (80–99%) | In 2 conditions |
| SEMA4Dsemaphorin 4D | Very often (80–99%) | In 1 condition |
| SLC25A13solute carrier family 25 member 13 | Very often (80–99%) | In 1 condition |
| TCF4transcription factor 4 | Very often (80–99%) | In 1 condition |
| ADKadenosine kinase | Often (30–79%) | In 1 condition |
| AKR1D1aldo-keto reductase family 1 member D1 | Often (30–79%) | In 1 condition |
| ALG8ALG8 alpha-1,3-glucosyltransferase | Often (30–79%) | In 1 condition |
| AP1S1adaptor related protein complex 1 subunit sigma 1 | Often (30–79%) | In 1 condition |
| ATP7AATPase copper transporting alpha | Often (30–79%) | In 1 condition |
| CEP83centrosomal protein 83 | Often (30–79%) | In 1 condition |
| COG6component of oligomeric golgi complex 6 | Often (30–79%) | In 1 condition |
| CYP7B1cytochrome P450 family 7 subfamily B member 1 | Often (30–79%) | In 1 condition |
| DEF6DEF6 guanine nucleotide exchange factor | Often (30–79%) | In 1 condition |
Show 41 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| DZIP1LDAZ interacting zinc finger protein 1 like | Often (30–79%) | In 1 condition |
| IARS1isoleucyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| IFT56intraflagellar transport 56 | Often (30–79%) | In 1 condition |
| MED12mediator complex subunit 12 | Often (30–79%) | In 1 condition |
| PCSK1proprotein convertase subtilisin/kexin type 1 | Often (30–79%) | In 1 condition |
| POMCproopiomelanocortin | Often (30–79%) | In 2 conditions |
| RBCK1RANBP2-type and C3HC4-type zinc finger containing 1 | Often (30–79%) | In 1 condition |
| RFX6regulatory factor X6 | Often (30–79%) | In 1 condition |
| SAA1serum amyloid A1 | Often (30–79%) | In 1 condition |
| SHPKsedoheptulokinase | Often (30–79%) | In 1 condition |
| TMEM67transmembrane protein 67 | Often (30–79%) | In 1 condition |
| AGR2anterior gradient 2, protein disulphide isomerase family member | Sometimes (5–29%) | In 1 condition |
| ANKS6ankyrin repeat and sterile alpha motif domain containing 6 | Sometimes (5–29%) | In 1 condition |
| DHRSXdehydrogenase/reductase X-linked | Sometimes (5–29%) | In 1 condition |
| EARS2glutamyl-tRNA synthetase 2, mitochondrial | Sometimes (5–29%) | In 1 condition |
| GALMgalactose mutarotase | Sometimes (5–29%) | In 1 condition |
| GNB2G protein subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Sometimes (5–29%) | In 2 conditions |
| HADHBhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | Sometimes (5–29%) | In 1 condition |
| HSD17B4hydroxysteroid 17-beta dehydrogenase 4 | Sometimes (5–29%) | In 1 condition |
| IFT140intraflagellar transport 140 | Sometimes (5–29%) | In 1 condition |
| IFT54intraflagellar transport 54 | Sometimes (5–29%) | In 1 condition |
| NPHP3nephrocystin 3 | Sometimes (5–29%) | In 2 conditions |
| PEX2peroxisomal biogenesis factor 2 | Sometimes (5–29%) | In 1 condition |
| PHKA2phosphorylase kinase regulatory subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| PHKG2phosphorylase kinase catalytic subunit gamma 2 | Sometimes (5–29%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Sometimes (5–29%) | In 1 condition |
| SERPINA1serpin family A member 1 | Sometimes (5–29%) | In 1 condition |
| ZNF699zinc finger protein 699 | Sometimes (5–29%) | In 1 condition |
| GNASGNAS complex locus | Rarely (1–4%) | In 1 condition |
| BLVRAbiliverdin reductase A | Not recorded | In 1 condition |
| FGAfibrinogen alpha chain | Not recorded | In 1 condition |
| GLIS3GLIS family zinc finger 3 | Not recorded | In 1 condition |
| IFT172intraflagellar transport 172 | Not recorded | In 1 condition |
| INSRinsulin receptor | Not recorded | In 1 condition |
| NEK8NIMA related kinase 8 | Not recorded | In 1 condition |
| NOTCH2notch receptor 2 | Not recorded | In 1 condition |
| RINT1RAD50 interactor 1 | Not recorded | In 1 condition |
| SKIC3SKI3 subunit of superkiller complex | Not recorded | In 1 condition |
| TBX19T-box transcription factor 19 | Not recorded | In 1 condition |
| WDR35WD repeat domain 35 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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