Trait
Schizophrenia
A mental disorder characterized by a disintegration of thought processes and emotional responsiveness. It most commonly manifests as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking. It is accompanied by significant social or occupational dysfunction. The onset of symptoms typically occurs in young adulthood, with a global lifetime prevalence of about 1%. This term is not a helpful parent term to describe abnormal experiences.
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test61 genes linked to Schizophrenia
Changes in these genes cause rare conditions in which Schizophrenia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCB7ATP binding cassette subfamily B member 7 | Always | In 2 conditions |
| CNTNAP2contactin associated protein 2 | Always | In 1 condition |
| NIT1nitrilase 1 | Always | In 1 condition |
| NRXN1neurexin 1 | Always | In 1 condition |
| PRODHproline dehydrogenase 1 | Always | In 3 conditions |
| SHANK3SH3 and multiple ankyrin repeat domains 3 | Always | In 1 condition |
| RBM12RNA binding motif protein 12 | Often (30–79%) | In 1 condition |
| AMACRalpha-methylacyl-CoA racemase | Sometimes (5–29%) | In 1 condition |
| ARSAarylsulfatase A | Sometimes (5–29%) | In 1 condition |
| ARVCFARVCF delta catenin family member | Sometimes (5–29%) | In 1 condition |
| ATG7autophagy related 7 | Sometimes (5–29%) | In 1 condition |
| CHRNA7cholinergic receptor nicotinic alpha 7 subunit | Sometimes (5–29%) | In 1 condition |
| COMTcatechol-O-methyltransferase | Sometimes (5–29%) | In 1 condition |
| DNMT3ADNA methyltransferase 3 alpha | Sometimes (5–29%) | In 1 condition |
| DSG4desmoglein 4 | Sometimes (5–29%) | In 1 condition |
| FLI1Fli-1 proto-oncogene, ETS transcription factor | Sometimes (5–29%) | In 1 condition |
| FTSJ1FtsJ RNA 2'-O-methyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Sometimes (5–29%) | In 1 condition |
| HIRAhistone cell cycle regulator | Sometimes (5–29%) | In 1 condition |
| JMJD1Cjumonji domain containing 1C | Sometimes (5–29%) | In 1 condition |
| KRT81keratin 81 | Sometimes (5–29%) | In 1 condition |
| KRT83keratin 83 | Sometimes (5–29%) | In 1 condition |
| KRT86keratin 86 | Sometimes (5–29%) | In 1 condition |
| MED12mediator complex subunit 12 | Sometimes (5–29%) | In 1 condition |
| MSTO1misato mitochondrial distribution and morphology regulator 1 | Sometimes (5–29%) | In 2 conditions |
| NIPA1NIPA magnesium transporter 1 | Sometimes (5–29%) | In 1 condition |
| NIPA2NIPA magnesium transporter 2 | Sometimes (5–29%) | In 1 condition |
| PSAPprosaposin | Sometimes (5–29%) | In 1 condition |
| RREB1ras responsive element binding protein 1 | Sometimes (5–29%) | In 1 condition |
| SEC24CSEC24 homolog C, COPII component | Sometimes (5–29%) | In 1 condition |
| SETD1ASET domain containing 1A, histone lysine methyltransferase | Sometimes (5–29%) | In 1 condition |
| SLC1A1solute carrier family 1 member 1 | Sometimes (5–29%) | In 1 condition |
| TBX1T-box transcription factor 1 | Sometimes (5–29%) | In 2 conditions |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 1 condition |
| TUBG1tubulin gamma 1 | Sometimes (5–29%) | In 1 condition |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Sometimes (5–29%) | In 1 condition |
| UPF3BUPF3B regulator of nonsense mediated mRNA decay | Sometimes (5–29%) | In 1 condition |
| ZBTB20zinc finger and BTB domain containing 20 | Sometimes (5–29%) | In 1 condition |
| ZDHHC9zDHHC palmitoyltransferase 9 | Sometimes (5–29%) | In 1 condition |
| CATcatalase | Rarely (1–4%) | In 1 condition |
Show 21 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| DNAJC13DnaJ heat shock protein family (Hsp40) member C13 | Rarely (1–4%) | In 1 condition |
| EIF4G1eukaryotic translation initiation factor 4 gamma 1 | Rarely (1–4%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Rarely (1–4%) | In 1 condition |
| GIGYF2GRB10 interacting GYF protein 2 | Rarely (1–4%) | In 1 condition |
| LRRK2leucine rich repeat kinase 2 | Rarely (1–4%) | In 1 condition |
| MT-TEmitochondrially encoded tRNA-Glu (GAA/G) | Rarely (1–4%) | In 1 condition |
| NKX2-1NK2 homeobox 1 | Rarely (1–4%) | In 1 condition |
| SNCAsynuclein alpha | Rarely (1–4%) | In 1 condition |
| VPS35VPS35 retromer complex component | Rarely (1–4%) | In 1 condition |
| APOL2apolipoprotein L2 | Not recorded | In 1 condition |
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Not recorded | In 1 condition |
| CHI3L1chitinase 3 like 1 | Not recorded | In 1 condition |
| DAOAD-amino acid oxidase activator | Not recorded | In 1 condition |
| DISC2disrupted in schizophrenia 2 | Not recorded | In 1 condition |
| DRD3dopamine receptor D3 | Not recorded | In 1 condition |
| GJA5gap junction protein alpha 5 | Not recorded | In 1 condition |
| GJA8gap junction protein alpha 8 | Not recorded | In 1 condition |
| HTR2A5-hydroxytryptamine receptor 2A | Not recorded | In 1 condition |
| MTHFRmethylenetetrahydrofolate reductase | Not recorded | In 1 condition |
| RTN4Rreticulon 4 receptor | Not recorded | In 1 condition |
| SYN2synapsin II | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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