Trait
Hypermobility of all joints
Clinical name: Generalized joint hypermobility
Joint hypermobility (ability of a joint to move beyond its normal range of motion) affecting many or all joints of the body. In individuals with Joint hypermobility at multiple sites (usually five or more), the term generalized joint hypermobility is preferred.
Summary
- Also called
- Generalised joint laxity, Generalized joint laxity
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
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Read the genes linked to Hypermobility of all joints, and the rest of your genome, with one test.
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Get my Genome Test56 genes linked to Hypermobility of all joints
Changes in these genes cause rare conditions in which Hypermobility of all joints is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AEBP1AE binding protein 1 | Always | In 1 condition |
| IFT140intraflagellar transport 140 | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| MARK2microtubule affinity regulating kinase 2 | Always | In 1 condition |
| SERPINH1serpin family H member 1 | Always | In 1 condition |
| ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2 | Very often (80–99%) | In 1 condition |
| ADAMTSL2ADAMTS like 2 | Very often (80–99%) | In 1 condition |
| ATP6V0A2ATPase H+ transporting V0 subunit a2 | Very often (80–99%) | In 2 conditions |
| ATP6V1AATPase H+ transporting V1 subunit A | Very often (80–99%) | In 1 condition |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Very often (80–99%) | In 1 condition |
| CHST14carbohydrate sulfotransferase 14 | Very often (80–99%) | In 2 conditions |
| COL1A1collagen type I alpha 1 chain | Very often (80–99%) | In 2 conditions |
| COL1A2collagen type I alpha 2 chain | Very often (80–99%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Very often (80–99%) | In 1 condition |
| COL5A1collagen type V alpha 1 chain | Very often (80–99%) | In 1 condition |
| COL5A2collagen type V alpha 2 chain | Very often (80–99%) | In 2 conditions |
| DSEdermatan sulfate epimerase | Very often (80–99%) | In 1 condition |
| TNXBtenascin XB | Very often (80–99%) | In 1 condition |
| COMPcartilage oligomeric matrix protein | Often (30–79%) | In 2 conditions |
| KIF22kinesin family member 22 | Often (30–79%) | In 1 condition |
| MCTP2multiple C2 and transmembrane domain containing 2 | Often (30–79%) | In 1 condition |
| MED12mediator complex subunit 12 | Often (30–79%) | In 1 condition |
| MSTO1misato mitochondrial distribution and morphology regulator 1 | Often (30–79%) | In 1 condition |
| PLOD1procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Often (30–79%) | In 1 condition |
| PUF60poly(U) binding splicing factor 60 | Often (30–79%) | In 1 condition |
| C1Rcomplement C1r | Sometimes (5–29%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Sometimes (5–29%) | In 1 condition |
| DUSP6dual specificity phosphatase 6 | Sometimes (5–29%) | In 1 condition |
| EMX2empty spiracles homeobox 2 | Sometimes (5–29%) | In 1 condition |
| FGF17fibroblast growth factor 17 | Sometimes (5–29%) | In 1 condition |
| FGF8fibroblast growth factor 8 | Sometimes (5–29%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Sometimes (5–29%) | In 1 condition |
| GNRH1gonadotropin releasing hormone 1 | Sometimes (5–29%) | In 1 condition |
| GNRHRgonadotropin releasing hormone receptor | Sometimes (5–29%) | In 1 condition |
| HS6ST1heparan sulfate 6-O-sulfotransferase 1 | Sometimes (5–29%) | In 1 condition |
| IPO8importin 8 | Sometimes (5–29%) | In 1 condition |
| KISS1KiSS-1 metastasis suppressor | Sometimes (5–29%) | In 1 condition |
| KISS1RKISS1 receptor | Sometimes (5–29%) | In 1 condition |
| NHLH2nescient helix-loop-helix 2 | Sometimes (5–29%) | In 1 condition |
| NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor | Sometimes (5–29%) | In 1 condition |
Show 16 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| PHIPPHIP subunit of CUL4-Ring ligase complex | Sometimes (5–29%) | In 1 condition |
| PROK2prokineticin 2 | Sometimes (5–29%) | In 1 condition |
| PROKR2prokineticin receptor 2 | Sometimes (5–29%) | In 1 condition |
| SATB2SATB homeobox 2 | Sometimes (5–29%) | In 1 condition |
| SPRY4sprouty RTK signaling antagonist 4 | Sometimes (5–29%) | In 1 condition |
| TAC3tachykinin precursor 3 | Sometimes (5–29%) | In 1 condition |
| TACR3tachykinin receptor 3 | Sometimes (5–29%) | In 1 condition |
| TONSLtonsoku like, DNA repair protein | Sometimes (5–29%) | In 1 condition |
| WDR11WD repeat domain 11 | Sometimes (5–29%) | In 1 condition |
| AP4B1adaptor related protein complex 4 subunit beta 1 | Rarely (1–4%) | In 1 condition |
| AP4E1adaptor related protein complex 4 subunit epsilon 1 | Rarely (1–4%) | In 1 condition |
| AP4M1adaptor related protein complex 4 subunit mu 1 | Rarely (1–4%) | In 1 condition |
| AP4S1adaptor related protein complex 4 subunit sigma 1 | Rarely (1–4%) | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Not recorded | In 1 condition |
| LONP1lon peptidase 1, mitochondrial | Not recorded | In 1 condition |
| TDO2tryptophan 2,3-dioxygenase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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