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Gene

HLA-B

major histocompatibility complex, class I, B

Summary

Cytogenetic location
6p21.33
Coordinates
Chromosome 6: 31,353,875–31,357,179 (GRCh38)
Exons
8 exons across 3.3 kb
Protein
362 amino acids
Previous symbols
AS
MANE Select transcript
ENST00000412585.7NM_005514.8
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads HLA-B yet. The test sequences your whole genome, so your data includes it all the same.

How HLA-B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 6, with a bracket where HLA-B sits. HLA-B and 57 genes near it on chromosome 6, from 30,855,527 to 31,855,526.Chromosome 66p21.33p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2731 Mb31.2 Mb31.4 Mb31.6 Mb31.8 MbDDR1: 30,876,421–30,900,978, forward strandDDR1GTF2H4: 30,907,517–30,914,119, forward strandVARS2: 30,914,205–30,928,614, forward strandVARS2SFTA2: 30,931,353–30,955,636, reverse strandSFTA2SFTA2-AS1: 30,934,523–30,938,824, forward strandSFTA2-AS1MUCL3: 30,940,973–30,954,221, forward strandMUCL3MUC21: 30,983,718–30,989,903, forward strandMUC21MUC22: 31,010,474–31,036,882, forward strandMUC22C6orf15: 31,111,223–31,112,582, reverse strandPSORS1C1: 31,114,750–31,140,092, forward strandCDSN: 31,115,087–31,120,446, reverse strandPSORS1C2: 31,137,534–31,139,721, reverse strandPSORS1C2CCHCR1: 31,142,439–31,158,238, reverse strandCCHCR1TCF19: 31,158,331–31,167,252, forward strandTCF19POU5F1: 31,163,193–31,180,731, reverse strandPOU5F1HLA-C: 31,268,746–31,272,171, reverse strandHLA-CHLA-B: 31,353,875–31,357,179, reverse strandHLA-BMICA: 31,399,784–31,415,315, forward strandMICAMICB: 31,494,881–31,511,124, forward strandMICBMCCD1: 31,528,962–31,530,232, forward strandMCCD1DDX39B: 31,530,217–31,542,451, reverse strandDDX39BATP6V1G2-DDX39B: 31,530,219–31,546,608, reverse strandATP6V1G2-DDX39BATP6V1G2: 31,544,444–31,548,427, reverse strandNFKBIL1: 31,546,870–31,558,829, forward strandLTA: 31,572,054–31,574,324, forward strandTNF: 31,575,558–31,578,336, forward strandTNFLTB: 31,580,525–31,582,522, reverse strandLST1: 31,581,065–31,588,911, forward strandNCR3: 31,588,895–31,593,217, reverse strandAIF1: 31,615,214–31,617,025, forward strandAIF1PRRC2A: 31,620,675–31,637,771, forward strand: 31,622,774–31,622,860, forward strand: 31,623,874–31,625,499, forward strandBAG6: 31,638,543–31,652,747, reverse strandAPOM: 31,652,416–31,658,214, forward strandAPOMC6orf47: 31,658,298–31,660,778, reverse strandGPANK1: 31,661,228–31,666,283, reverse strandCSNK2B: 31,665,227–31,670,343, forward strand: 31,666,102–31,673,546, forward strandLY6G5B: 31,669,976–31,673,776, forward strandLY6G5C: 31,676,684–31,684,040, reverse strandABHD16A: 31,686,954–31,703,391, reverse strandLY6G6F: 31,706,863–31,710,801, forward strandLY6G6FLY6G6F-LY6G6D: 31,706,904–31,717,918, forward strandLY6G6D: 31,715,285–31,717,919, forward strandLY6G6DMPIG6B: 31,718,594–31,726,714, forward strandLY6G6C: 31,718,648–31,721,746, reverse strandLY6G6CDDAH2: 31,726,586–31,730,617, reverse strandCLIC1: 31,730,579–31,740,558, reverse strandMSH5: 31,739,677–31,762,678, forward strandMSH5-SAPCD1: 31,740,020–31,764,851, forward strandSAPCD1: 31,762,656–31,764,851, forward strandVWA7: 31,765,590–31,777,328, reverse strandVARS1: 31,777,518–31,795,975, reverse strandVARS1LSM2: 31,797,019–31,806,992, reverse strandLSM2HSPA1L: 31,809,619–31,815,788, reverse strandHSPA1LHSPA1A: 31,815,543–31,817,994, forward strandHSPA1AHSPA1B: 31,827,738–31,830,254, forward strandDiagram of HLA-B: 8 exons on the reverse strand of chromosome 6Exon 8: 31,353,875–31,354,296, 422 basesExon 7: 31,354,479–31,354,526, 48 basesExon 6: 31,354,633–31,354,665, 33 basesExon 5: 31,355,107–31,355,223, 117 basesExon 4: 31,355,317–31,355,592, 276 basesExon 3: 31,356,167–31,356,442, 276 basesExon 2: 31,356,688–31,356,957, 270 basesExon 1: 31,357,086–31,357,179, 94 bases876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.5 kb of the gene's 3.3 kb; 1,089 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). HLA-B gene: major histocompatibility complex, class I, B. Retrieved 17 October 2026, from https://dantelabs.com/genes/hla-b

Vancouver

Dante Labs. HLA-B gene: major histocompatibility complex, class I, B [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hla-b

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