Gen
HLA-B
major histocompatibility complex, class I, B
- HGNC 4932↗(öppnas i en ny flik)
- Ensembl-gen ENSG00000234745↗(öppnas i en ny flik)
- NCBI Gene 3106↗(öppnas i en ny flik)
Sammanfattning
- Cytogenetisk position
- 6p21.33
- Koordinater
- Kromosom 6: 31 353 875–31 357 179 (GRCh38)
- Exoner
- 8 exoner på 3,3 kb
- Protein
- 362 aminosyror
- Tidigare symboler
- AS
- MANE Select-transkript
- ENST00000412585.7NM_005514.8
- Lokustyp
- gene with protein product
- Mycket hög
- Säker
- Låg
- Mycket låg
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Beställ mitt Genome TestKuraterade rapporter som är relevanta för denna gen
Ingen Genome Test-rapport läser HLA-B ännu. Testet sekvenserar hela ditt genom, så dina data innehåller den ändå.
Så är HLA-B uppbyggd
- Kodande sekvens
- Otranslaterad region
- Intron
- Transkriptionsriktning
- Sträckor som korta läsningar har svårt för
Exoner i genens MANE Select-transkript (version v1.5), från NCBI och EMBL-EBI, på referensgenomet GRCh38.
Kromosombanden från UCSC:s GRCh38-ideogram (2022-10-29).
Närliggande gener från Ensembl-version 116, på GRCh38.
Exoner utgör 1,5 kb av genens 3,3 kb, och 1 089 av dessa baser kodar för proteinet.
Egenskaper kopplade till HLA-B
Human Phenotype Ontology listar dessa som kännetecken för de sällsynta tillstånd som HLA-B kan orsaka. Varje egenskaps sida visar de andra gener som är kopplade till den.
Abnormality of the cardiovascular system
- Abnormal heart valve morphology
- Aneurysm
- Disruption of blood oxygen supply to brain
- Hypertensive crisis
- Inflammation of artery
- Inflammation of blood vessel
- Narrowing of an artery
- Redness of skin or mucous membrane
Visa ytterligare 33 egenskaper
- Abnormal aortic valve morphology
- Abnormal systemic blood pressure
- Absent pulse
- Asymmetric blood pressure between arms
- Blood pressure substantially higher in legs than arms
- Bulging of wall of large artery located above heart
- Heart attack
- High blood pressure
- Increased blood pressure in blood vessels of lungs
- Intermittent claudication
- Jaw pain while chewing
- Narrowing of kidney artery
- Abdominal aortic aneurysm
- Abnormal endocardium morphology
- Abnormal heart rate
- Abnormal myocardium morphology
- Absent superficial temporal artery pulse
- Aortic regurgitation
- Blood clot in artery of lung
- Cardiac failure
- Double outlet right ventricle with subpulmonary ventricular septal defect without pulmonary stenosis
- Endocarditis
- Increased spleen size
- Inflammation of heart muscle
- Mini stroke
- Mitral regurgitation
- Stretched and thinned heart muscle
- Stroke
- Sudden cardiac death
- Swelling or irritation of membrane around heart
- Swollen lymph nodes
- Swollen lymph nodes in center of chest
- Tear in inner wall of large artery that carries blood away from heart
Abnormality of the nervous system
- Cognitive impairment
- Headache
- Migraine
- Abnormal gait
- Confusion
- Depression
- Epilepsy
- Weakness of one side of body
Visa ytterligare 15 egenskaper
- Abnormal pyramidal sign
- Abnormal speech pattern
- Ataxia
- Behavioral abnormality
- Cranial nerve paralysis
- Difficulty articulating speech
- Disturbances of consciousness
- Increased reflexes
- Irritability
- Loss of developmental milestones
- Memory impairment
- Peripheral neuropathy
- Pins and needles feeling
- Rise in pressure inside skull
- Visual hallucinations
Abnormality of the eye
- Extreme sensitivity of the eyes to light
- Blurred vision
- Inflammation of iris
- Nongranulomatous uveitis
- Panuveitis
- Visual impairment
- Weakness of muscles controlling eye movement
- Amaurosis fugax
Visa ytterligare 14 egenskaper
- Blindness
- Clouding of the lens of the eye
- Damage to outer layer of the cornea of the eye
- Double vision
- Drooping upper eyelid
- Involuntary, rapid, rhythmic eye movements
- Noninflammatory retina disease
- Optic atrophy
- Optic neuritis
- Partial loss of field of vision
- Retrobulbar optic neuritis
- Uveitis
- Visual loss
- Anterior uveitis
Abnormality of the musculoskeletal system
- Arthritis
- Cartilage destruction
- Enthesitis
- Joint stiffness
- Lumbago
- Muscle weakness
- Polyarticular arthritis
- Death of bone due to decreased blood supply
Visa ytterligare 5 egenskaper
Laboratory abnormality
- Elevated circulating C-reactive protein concentration
- Fever
- Joint swelling
- Elevated circulating alpha-globulin concentration
- Elevated circulating calprotectin concentration
- Elevated circulating osteopontin concentration
- High ESR
- AA amyloidosis
Visa ytterligare 5 egenskaper
Abnormality of the digestive system
- Anorexia
- Diarrhea
- Nausea and vomiting
- Abdominal pain
- Inflammation of the large intestine
- Poor swallowing
- Acute liver failure
- Death of digestive organ tissue due to poor blood supply
Visa ytterligare 4 egenskaper
Abnormality of the genitourinary system
- Inflammation of testicles
- Genital ulcers
- Balanitis
- Dull burning sensation with urination
- Dyspareunia
- Epididymitis
- Frequent urinary tract infections
- Glomerulopathy
Visa ytterligare 4 egenskaper
Abnormality of the integument
- Abnormal blistering of the skin
- Abnormality of the nail
- Acantholysis
- Firm lump under the skin
- Flat, discolored area of skin
- Hyperkeratosis
- Papule
- Poor fingernail formation
Visa ytterligare 4 egenskaper
Abnormality of blood and blood-forming tissues
- Abnormality of neutrophils
- Blood clot in vein
- Gastrointestinal bleeding
- Hyperfibrinogenemia
- Low number of red blood cells or hemoglobin
- Superficial thrombophlebitis
- Blood clot in artery
- Bloody nose
Visa ytterligare 2 egenskaper
Abnormality of head or neck
- Chewing difficulties
- Mouth sore
- Pink eye
- Recurrent canker sores
- Excessive salivation
- Dry eye syndrome
- Eyelid folded in
- Inflammation of the tongue
Visa ytterligare 2 egenskaper
Abnormality of the respiratory system
- Abnormal pleura morphology
- Breathing difficulty
- Cough
- Coughing up blood
- Dry cough
- Inflammation of tissues lining lungs and chest
- Lung infiltrates
- Pulmonary scarring
Visa ytterligare 2 egenskaper
Externa länkar
Genposter
Transkript
Protein
Varifrån detta kommer
- HGNC: genens symbol, namn, andra symboler och position.
- MANE Select v1.5, från NCBI och EMBL-EBI: transkriptet, dess exoner och kodande sekvens.
- Human Phenotype Ontology, version 2026-09-01: egenskaperna som är kopplade till genen. Läs mer på hpo.jax.org.
Citera den här sidan
Dante Labs. (u.å.). HLA-B-genen: major histocompatibility complex, class I, B. Hämtad 17 oktober 2026, från https://dantelabs.com/sv/genes/hla-b
Dante Labs. HLA-B-genen: major histocompatibility complex, class I, B [Internet]. [citerad 17 oktober 2026]. Tillgänglig på: https://dantelabs.com/sv/genes/hla-b
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