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Trait

Acantholysis

The loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes.

HPO HP:0100792

Summary

Body system
Abnormality of the integument

8 condition reports read genes linked to this trait

Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.

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10 genes linked to Acantholysis

Changes in these genes cause rare conditions in which Acantholysis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
CASTcalpastatinAlwaysIn 1 condition
DSG1desmoglein 1AlwaysIn 1 condition
DSPdesmoplakinAlwaysIn 3 conditions
JUPjunction plakoglobinAlwaysIn 2 conditions
TUFT1tuftelin 1AlwaysIn 1 condition
ATP2C1ATPase secretory pathway Ca2+ transporting 1Very often (80–99%)In 1 condition
HLA-Bmajor histocompatibility complex, class I, BVery often (80–99%)In 1 condition
IKZF1IKAROS family zinc finger 1Very often (80–99%)In 1 condition
KRT2keratin 2Very often (80–99%)In 1 condition
ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2Not recordedIn 2 conditions

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal epidermal morphology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.19-9814e911.

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