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Gene

GTF2H4

general transcription factor IIH subunit 4

Summary

Cytogenetic location
6p21.33
Coordinates
Chromosome 6: 30,908,207–30,914,106 (GRCh38)
Exons
14 exons across 5.9 kb
Protein
462 amino acids
Also known as
TFB2, TFIIH, P52
MANE Select transcript
ENST00000259895.9NM_001517.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads GTF2H4 yet. The test sequences your whole genome, so your data includes it all the same.

How GTF2H4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 6, with a bracket where GTF2H4 sits. GTF2H4 and 32 genes near it on chromosome 6, from 30,411,157 to 31,411,156.Chromosome 66p21.33p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2730.6 Mb30.8 Mb31 Mb31.2 Mb31.4 MbHLA-E: 30,489,495–30,494,205, forward strandHLA-EGNL1: 30,541,212–30,556,603, reverse strandGNL1PRR3: 30,556,704–30,563,723, forward strandPRR3ABCF1: 30,571,383–30,597,179, forward strandABCF1PPP1R10: 30,600,400–30,618,612, reverse strandMRPS18B: 30,617,759–30,626,398, forward strandMRPS18BATAT1: 30,626,837–30,646,835, forward strandATAT1C6orf136: 30,647,003–30,653,225, forward strandDHX16: 30,652,469–30,673,059, reverse strandDHX16PPP1R18: 30,676,389–30,687,895, reverse strandNRM: 30,688,047–30,691,420, reverse strandNRMMDC1: 30,699,807–30,717,562, reverse strandMDC1TUBB: 30,717,435–30,725,538, forward strandTUBBFLOT1: 30,727,709–30,743,075, reverse strandFLOT1IER3: 30,743,199–30,744,555, reverse strandIER3DDR1: 30,876,421–30,900,978, forward strandDDR1GTF2H4: 30,908,207–30,914,106, forward strandGTF2H4VARS2: 30,914,205–30,928,614, forward strandVARS2SFTA2: 30,931,353–30,955,636, reverse strandSFTA2SFTA2-AS1: 30,934,523–30,938,824, forward strandSFTA2-AS1MUCL3: 30,940,973–30,954,221, forward strandMUC21: 30,983,718–30,989,903, forward strandMUC21MUC22: 31,010,474–31,036,882, forward strandMUC22C6orf15: 31,111,223–31,112,582, reverse strandC6orf15PSORS1C1: 31,114,750–31,140,092, forward strandPSORS1C1CDSN: 31,115,087–31,120,446, reverse strandCDSNPSORS1C2: 31,137,534–31,139,721, reverse strandPSORS1C2CCHCR1: 31,142,439–31,158,238, reverse strandTCF19: 31,158,331–31,167,252, forward strandPOU5F1: 31,163,193–31,180,731, reverse strandPOU5F1HLA-C: 31,268,746–31,272,171, reverse strandHLA-CHLA-B: 31,353,195–31,367,067, reverse strandHLA-BMICA: 31,399,784–31,415,315, forward strandMICADiagram of GTF2H4: 14 exons on the forward strand of chromosome 6Exon 1: 30,908,207–30,908,403, 197 basesExon 2: 30,909,034–30,909,173, 140 basesExon 3: 30,909,435–30,909,539, 105 basesExon 4: 30,909,932–30,910,063, 132 basesExon 5: 30,910,665–30,910,761, 97 basesExon 6: 30,910,853–30,910,941, 89 basesExon 7: 30,911,158–30,911,269, 112 basesExon 8: 30,911,431–30,911,499, 69 basesExon 9: 30,911,684–30,911,767, 84 basesExon 10: 30,912,014–30,912,146, 133 basesExon 11: 30,912,328–30,912,458, 131 basesExon 12: 30,913,110–30,913,157, 48 basesExon 13: 30,913,309–30,913,387, 79 basesExon 14: 30,913,811–30,914,106, 296 bases12345678910111213145′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.7 kb of the gene's 5.9 kb; 1,389 of those bases code for the protein.

Traits linked to GTF2H4

The Human Phenotype Ontology lists these as features of the rare conditions GTF2H4 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). GTF2H4 gene: general transcription factor IIH subunit 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/gtf2h4

Vancouver

Dante Labs. GTF2H4 gene: general transcription factor IIH subunit 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/gtf2h4

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