Trait
Acute liver failure
Clinical name: Acute hepatic failure
Hepatic failure refers to the inability of the liver to perform its normal synthetic and metabolic functions, which can result in coagulopathy and alteration in the mental status of a previously healthy individual. Hepatic failure is defined as acute if there is onset of encephalopathy within 8 weeks of the onset of symptoms in a patient with a previously healthy liver.
Summary
- Body system
- Abnormality of the digestive system
Reference genomeGRCh38hg38
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Get my Genome Test28 genes linked to Acute liver failure
Changes in these genes cause rare conditions in which Acute liver failure is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| LIPAlipase A, lysosomal acid type | Always | In 2 conditions |
| MPV17mitochondrial inner membrane protein MPV17 | Always | In 1 condition |
| TRMUtRNA mitochondrial 2-thiouridylase | Always | In 1 condition |
| ATP7BATPase copper transporting beta | Very often (80–99%) | In 2 conditions |
| CYC1cytochrome c1 | Often (30–79%) | In 1 condition |
| EIF2AK3eukaryotic translation initiation factor 2 alpha kinase 3 | Often (30–79%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 2 conditions |
| SCYL1SCY1 like pseudokinase 1 | Often (30–79%) | In 1 condition |
| ACAD9acyl-CoA dehydrogenase family member 9 | Sometimes (5–29%) | In 1 condition |
| CACNA1Scalcium voltage-gated channel subunit alpha1 S | Sometimes (5–29%) | In 1 condition |
| CALRcalreticulin | Sometimes (5–29%) | In 1 condition |
| F5coagulation factor V | Sometimes (5–29%) | In 1 condition |
| FAHfumarylacetoacetate hydrolase | Sometimes (5–29%) | In 2 conditions |
| HLA-Bmajor histocompatibility complex, class I, B | Sometimes (5–29%) | In 1 condition |
| IKZF1IKAROS family zinc finger 1 | Sometimes (5–29%) | In 1 condition |
| ITCHitchy E3 ubiquitin protein ligase | Sometimes (5–29%) | In 1 condition |
| JAK2Janus kinase 2 | Sometimes (5–29%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 1 condition |
| ZNFX1zinc finger NFX1-type containing 1 | Sometimes (5–29%) | In 1 condition |
| GPR35G protein-coupled receptor 35 | Rarely (1–4%) | In 1 condition |
| HADHhydroxyacyl-CoA dehydrogenase | Rarely (1–4%) | In 1 condition |
| MST1macrophage stimulating 1 | Rarely (1–4%) | In 1 condition |
| SEMA4Dsemaphorin 4D | Rarely (1–4%) | In 1 condition |
| TCF4transcription factor 4 | Rarely (1–4%) | In 1 condition |
| LARS1leucyl-tRNA synthetase 1 | Not recorded | In 1 condition |
| NBASNBAS subunit of NRZ tethering complex | Not recorded | In 1 condition |
| RINT1RAD50 interactor 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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