Trait
Tear in inner wall of large artery that carries blood away from heart
Clinical name: Aortic dissection
Aortic dissection refers to a tear in the intimal layer of the aorta causing a separation between the intima and the medial layers of the aorta.
Summary
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test35 genes linked to Tear in inner wall of large artery that carries blood away from heart
Changes in these genes cause rare conditions in which Tear in inner wall of large artery that carries blood away from heart is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| MYH11myosin heavy chain 11 | Always | In 3 conditions |
| IPO8importin 8 | Very often (80–99%) | In 1 condition |
| SMAD2SMAD family member 2 | Very often (80–99%) | In 2 conditions |
| SMAD3SMAD family member 3 | Very often (80–99%) | In 4 conditions |
| TGFB2transforming growth factor beta 2 | Very often (80–99%) | In 3 conditions |
| TGFB3transforming growth factor beta 3 | Very often (80–99%) | In 2 conditions |
| TGFBR1transforming growth factor beta receptor 1 | Very often (80–99%) | In 2 conditions |
| TGFBR2transforming growth factor beta receptor 2 | Very often (80–99%) | In 2 conditions |
| SLC2A10solute carrier family 2 member 10 | Often (30–79%) | In 1 condition |
| ACTA2actin alpha 2, smooth muscle | Sometimes (5–29%) | In 1 condition |
| ANGPTL6angiopoietin like 6 | Sometimes (5–29%) | In 1 condition |
| BGNbiglycan | Sometimes (5–29%) | In 1 condition |
| COL3A1collagen type III alpha 1 chain | Sometimes (5–29%) | In 3 conditions |
| EFEMP2EGF-like fibulin extracellular matrix protein 2 | Sometimes (5–29%) | In 1 condition |
| ELNelastin | Sometimes (5–29%) | In 1 condition |
| ENGendoglin | Sometimes (5–29%) | In 1 condition |
| FBN1fibrillin 1 | Sometimes (5–29%) | In 2 conditions |
| FOXE3forkhead box E3 | Sometimes (5–29%) | In 1 condition |
| HEY2hes related family bHLH transcription factor with YRPW motif 2 | Sometimes (5–29%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Sometimes (5–29%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 1 condition |
| LOXlysyl oxidase | Sometimes (5–29%) | In 1 condition |
| MAT2Amethionine adenosyltransferase 2A | Sometimes (5–29%) | In 1 condition |
| MFAP5microfibril associated protein 5 | Sometimes (5–29%) | In 1 condition |
| MYLKmyosin light chain kinase | Sometimes (5–29%) | In 1 condition |
| P4HA2prolyl 4-hydroxylase subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| PLOD1procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Sometimes (5–29%) | In 1 condition |
| PRKG1protein kinase cGMP-dependent 1 | Sometimes (5–29%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Sometimes (5–29%) | In 1 condition |
| SMAD4SMAD family member 4 | Sometimes (5–29%) | In 1 condition |
| TGFBR3transforming growth factor beta receptor 3 | Sometimes (5–29%) | In 1 condition |
| THSD1thrombospondin type 1 domain containing 1 | Sometimes (5–29%) | In 1 condition |
| THSD4thrombospondin type 1 domain containing 4 | Sometimes (5–29%) | In 1 condition |
| ABCC6ATP binding cassette subfamily C member 6 | Rarely (1–4%) | In 1 condition |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Rarely (1–4%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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