Trait

Aneurysm

Clinical name: Vascular dilatation

An abnormal increase in the diameter of an artery or vein, either as a diffuse dilatation or as a localized, sac-like outpouching of the vessel wall (aneurysm).

HPO HP:0002617

Also called: Aneurysmal disease, Aneurysms, Wider than typical opening or gap, Aneurysmal dilatation
Body system: Abnormality of the cardiovascular system

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/vascular-dilatation.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

Read the genes linked to Aneurysm, and the rest of your genome, with one test.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test

46 genes linked to Aneurysm

Changes in these genes cause rare conditions in which Aneurysm is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
NOTCH3notch receptor 3	Always	In 1 condition
ATP7AATPase copper transporting alpha	Very often (80–99%)	In 2 conditions
HLA-Bmajor histocompatibility complex, class I, B	Very often (80–99%)	In 1 condition
IL12Binterleukin 12B	Very often (80–99%)	In 1 condition
IPO8importin 8	Very often (80–99%)	In 1 condition
MLXMAX dimerization protein MLX	Very often (80–99%)	In 1 condition
SLC2A10solute carrier family 2 member 10	Very often (80–99%)	In 1 condition
SMAD2SMAD family member 2	Very often (80–99%)	In 1 condition
SMAD3SMAD family member 3	Very often (80–99%)	In 2 conditions
TGFB2transforming growth factor beta 2	Very often (80–99%)	In 1 condition
TGFB3transforming growth factor beta 3	Very often (80–99%)	In 1 condition
TGFBR1transforming growth factor beta receptor 1	Very often (80–99%)	In 1 condition
TGFBR2transforming growth factor beta receptor 2	Very often (80–99%)	In 1 condition
EPHB4EPH receptor B4	Often (30–79%)	In 1 condition
RASA1RAS p21 protein activator 1	Often (30–79%)	In 1 condition
ALG8ALG8 alpha-1,3-glucosyltransferase	Sometimes (5–29%)	In 1 condition
BRAFB-Raf proto-oncogene, serine/threonine kinase	Sometimes (5–29%)	In 1 condition
EFEMP2EGF-like fibulin extracellular matrix protein 2	Sometimes (5–29%)	In 1 condition
FBLN5fibulin 5	Sometimes (5–29%)	In 1 condition
LRP5LDL receptor related protein 5	Sometimes (5–29%)	In 1 condition
LTBP1latent transforming growth factor beta binding protein 1	Sometimes (5–29%)	In 1 condition
OFD1OFD1 centriole and centriolar satellite protein	Sometimes (5–29%)	In 2 conditions
PCNTpericentrin	Sometimes (5–29%)	In 1 condition
PLOD1procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Sometimes (5–29%)	In 1 condition
PRKCSHPRKCSH beta subunit of glucosidase II	Sometimes (5–29%)	In 1 condition
PTPN11protein tyrosine phosphatase non-receptor type 11	Sometimes (5–29%)	In 1 condition
RAF1Raf-1 proto-oncogene, serine/threonine kinase	Sometimes (5–29%)	In 1 condition
SEC63SEC63 protein translocation regulator	Sometimes (5–29%)	In 1 condition
STAT3signal transducer and activator of transcription 3	Sometimes (5–29%)	In 1 condition
PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha	Rarely (1–4%)	In 1 condition
ACTA2actin alpha 2, smooth muscle	Not recorded	In 1 condition
CAVIN1caveolae associated protein 1	Not recorded	In 1 condition
COL3A1collagen type III alpha 1 chain	Not recorded	In 1 condition
CRB2crumbs cell polarity complex component 2	Not recorded	In 1 condition
LTBP4latent transforming growth factor beta binding protein 4	Not recorded	In 1 condition
MKS1MKS transition zone complex subunit 1	Not recorded	In 1 condition
MNX1motor neuron and pancreas homeobox 1	Not recorded	In 1 condition
NPPAnatriuretic peptide A	Not recorded	In 1 condition
PAM16presequence translocase associated motor 16	Not recorded	In 1 condition
PBX1PBX homeobox 1	Not recorded	In 1 condition

Show 6 more genes

Gene	How often it is seen	Conditions
PEX12peroxisomal biogenesis factor 12	Not recorded	In 1 condition
SALL4spalt like transcription factor 4	Not recorded	In 1 condition
SOX10SRY-box transcription factor 10	Not recorded	In 1 condition
TMEM67transmembrane protein 67	Not recorded	In 1 condition
UBR1ubiquitin protein ligase E3 component n-recognin 1	Not recorded	In 1 condition
WDR19WD repeat domain 19	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal blood vessel morphology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

One test. A lifetime of answers.