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Gene

VARS1

valyl-tRNA synthetase 1

Summary

Cytogenetic location
6p21.33
Coordinates
Chromosome 6: 31,777,518–31,795,752 (GRCh38)
Exons
30 exons across 18.2 kb
Protein
1,264 amino acids
Previous symbols
VARS2, VARS
MANE Select transcript
ENST00000375663.8NM_006295.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads VARS1 yet. The test sequences your whole genome, so your data includes it all the same.

How VARS1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where VARS1 sits. VARS1 and 69 genes near it on chromosome 6, from 31,286,635 to 32,286,634.Chromosome 66p21.33p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2731.4 Mb31.6 Mb31.8 Mb32 Mb32.2 MbHLA-B: 31,353,195–31,367,067, reverse strandHLA-BMICA: 31,399,784–31,415,315, forward strandMICAMICB: 31,494,881–31,511,124, forward strandMICBMCCD1: 31,528,962–31,530,232, forward strandMCCD1DDX39B: 31,530,217–31,542,451, reverse strandDDX39BATP6V1G2-DDX39B: 31,530,219–31,546,608, reverse strandATP6V1G2: 31,544,444–31,548,427, reverse strandNFKBIL1: 31,546,870–31,558,829, forward strandLTA: 31,572,054–31,574,324, forward strandTNF: 31,575,558–31,578,336, forward strandTNFLTB: 31,580,525–31,582,522, reverse strandLST1: 31,581,065–31,588,911, forward strandLST1NCR3: 31,588,895–31,593,217, reverse strandNCR3AIF1: 31,615,214–31,617,025, forward strandAIF1PRRC2A: 31,620,675–31,637,771, forward strandPRRC2A: 31,622,774–31,622,860, forward strand: 31,623,874–31,625,499, forward strandBAG6: 31,638,543–31,652,747, reverse strandAPOM: 31,652,416–31,658,214, forward strandC6orf47: 31,658,298–31,660,778, reverse strandGPANK1: 31,661,228–31,666,283, reverse strandCSNK2B: 31,665,227–31,670,343, forward strand: 31,666,102–31,673,546, forward strandLY6G5B: 31,669,976–31,673,776, forward strandLY6G5C: 31,676,684–31,684,040, reverse strandLY6G5CABHD16A: 31,686,954–31,703,391, reverse strandABHD16ALY6G6F: 31,706,863–31,710,801, forward strandLY6G6F-LY6G6D: 31,706,904–31,717,918, forward strandLY6G6D: 31,715,285–31,717,919, forward strandMPIG6B: 31,718,594–31,726,714, forward strandLY6G6C: 31,718,648–31,721,746, reverse strandDDAH2: 31,726,586–31,730,617, reverse strandCLIC1: 31,730,579–31,740,558, reverse strandMSH5: 31,739,677–31,762,678, forward strandMSH5MSH5-SAPCD1: 31,740,020–31,764,851, forward strandSAPCD1: 31,762,656–31,764,851, forward strandSAPCD1VWA7: 31,765,590–31,777,328, reverse strandVWA7VARS1: 31,777,518–31,795,752, reverse strandVARS1LSM2: 31,797,019–31,806,992, reverse strandLSM2HSPA1L: 31,809,619–31,815,788, reverse strandHSPA1A: 31,815,543–31,817,994, forward strandHSPA1B: 31,827,738–31,830,254, forward strandHSPA1BNEU1: 31,857,063–31,862,905, reverse strandNEU1SLC44A4: 31,863,173–31,879,198, reverse strandSLC44A4EHMT2: 31,879,758–31,897,723, reverse strandEHMT2C2: 31,897,785–31,945,677, forward strandC2ZBTB12: 31,899,065–31,902,103, reverse strandZBTB12: 31,927,698–31,952,048, forward strandCFB: 31,945,650–31,952,086, forward strandCFBNELFE: 31,952,087–31,959,079, reverse strandSKIC2: 31,959,025–31,969,852, forward strandSKIC2DXO: 31,969,810–31,972,517, reverse strandWHR1: 31,971,091–31,982,821, forward strandC4A: 31,981,991–32,005,247, forward strandC4AC4B: 32,014,725–32,035,975, forward strandC4BCYP21A2: 32,038,297–32,042,321, forward strandCYP21A2TNXB: 32,041,153–32,115,334, reverse strandTNXBATF6B: 32,115,264–32,128,255, reverse strandATF6BFKBPL: 32,128,697–32,131,070, reverse strandFKBPLPPT2: 32,146,580–32,163,679, forward strandPRRT1: 32,147,292–32,153,083, reverse strandPRRT1: 32,150,495–32,154,373, reverse strandPPT2-EGFL8: 32,153,845–32,171,978, forward strandEGFL8: 32,163,918–32,171,980, forward strandAGPAT1: 32,167,118–32,178,112, reverse strandRNF5: 32,178,391–32,184,769, forward strandAGER: 32,180,963–32,184,365, reverse strandPBX2: 32,184,733–32,190,278, reverse strandGPSM3: 32,190,766–32,195,523, reverse strandNOTCH4: 32,194,843–32,224,111, reverse strandNOTCH4Diagram of VARS1: 30 exons on the reverse strand of chromosome 6Exon 29: 3 known disease-causing sitesExon 28: 3 known disease-causing sitesExon 27: 6 known disease-causing sitesExon 25: 3 known disease-causing sitesExon 20: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 9: 2 known disease-causing sitesExon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 30: 31,777,518–31,777,662, 145 basesExon 29: 31,778,967–31,779,292, 326 basesExon 28: 31,779,425–31,779,536, 112 basesExon 27: 31,779,608–31,779,814, 207 basesExon 26: 31,779,998–31,780,153, 156 basesExon 25: 31,780,441–31,780,568, 128 basesExon 24: 31,780,705–31,780,783, 79 basesExon 23: 31,780,870–31,780,938, 69 basesExon 22: 31,781,019–31,781,123, 105 basesExon 21: 31,781,481–31,781,606, 126 basesExon 20: 31,781,691–31,781,761, 71 basesExon 19: 31,781,847–31,781,952, 106 basesExon 18: 31,782,087–31,782,177, 91 basesExon 17: 31,782,285–31,782,443, 159 basesExon 16: 31,782,530–31,782,633, 104 basesExon 15: 31,782,721–31,782,845, 125 basesExon 14: 31,783,096–31,783,186, 91 basesExon 13: 31,784,214–31,784,308, 95 basesExon 12: 31,784,394–31,784,502, 109 basesExon 11: 31,784,595–31,784,714, 120 basesExon 10: 31,785,246–31,785,327, 82 basesExon 9: 31,785,569–31,785,733, 165 basesExon 8: 31,791,610–31,791,737, 128 basesExon 7: 31,791,871–31,791,971, 101 basesExon 6: 31,792,217–31,792,301, 85 basesExon 5: 31,792,392–31,792,516, 125 basesExon 4: 31,792,757–31,792,895, 139 basesExon 3: 31,792,986–31,793,120, 135 basesExon 2: 31,794,831–31,795,250, 420 basesExon 1: 31,795,546–31,795,752, 207 bases3025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.1 kb of the gene's 18.2 kb; 3,795 of those bases code for the protein.

How a genome test reads VARS1

25

positions in VARS1 where ClinVar classes a change as pathogenic or likely pathogenic

25 of them (100%) fall in regions short reads find hard.

  • MHC (25 sites)The major histocompatibility complex (HLA genes), highly polymorphic and poorly represented by a single reference.

A whole genome covers all 18.2 kb of VARS1, introns included, not only the 4.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). VARS1 gene: valyl-tRNA synthetase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/vars1

Vancouver

Dante Labs. VARS1 gene: valyl-tRNA synthetase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/vars1

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