Trait
Malaise
A feeling of general discomfort, weakness, or lack of health.
Summary
- Body system
- Constitutional symptom
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test48 genes linked to Malaise
Changes in these genes cause rare conditions in which Malaise is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATP7BATPase copper transporting beta | Always | In 1 condition |
| KLF1KLF transcription factor 1 | Always | In 1 condition |
| PACSIN3protein kinase C and casein kinase substrate in neurons 3 | Always | In 1 condition |
| BANK1B cell scaffold protein with ankyrin repeats 1 | Very often (80–99%) | In 1 condition |
| BLKBLK proto-oncogene, Src family tyrosine kinase | Very often (80–99%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Very often (80–99%) | In 1 condition |
| C4Bcomplement C4B (Chido/Rodgers blood group) | Very often (80–99%) | In 1 condition |
| CR2complement C3d receptor 2 | Very often (80–99%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Very often (80–99%) | In 1 condition |
| DNASE1deoxyribonuclease 1 | Very often (80–99%) | In 1 condition |
| ETS1ETS proto-oncogene 1, transcription factor | Very often (80–99%) | In 1 condition |
| FCGR2BFc gamma receptor IIb | Very often (80–99%) | In 1 condition |
| FCGR3BFc gamma receptor IIIb | Very often (80–99%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Very often (80–99%) | In 2 conditions |
| IGHG1immunoglobulin heavy constant gamma 1 (G1m marker) | Very often (80–99%) | In 1 condition |
| IL10interleukin 10 | Very often (80–99%) | In 1 condition |
| IRAK1interleukin 1 receptor associated kinase 1 | Very often (80–99%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Very often (80–99%) | In 1 condition |
| ITGAMintegrin subunit alpha M | Very often (80–99%) | In 1 condition |
| JAZF1JAZF zinc finger 1 | Very often (80–99%) | In 1 condition |
| KIAA0319LKIAA0319 like | Very often (80–99%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Very often (80–99%) | In 1 condition |
| PDCD1programmed cell death 1 | Very often (80–99%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Very often (80–99%) | In 2 conditions |
| PXKPX domain containing serine/threonine kinase like | Very often (80–99%) | In 1 condition |
| SPP1secreted phosphoprotein 1 | Very often (80–99%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Very often (80–99%) | In 1 condition |
| TLR7toll like receptor 7 | Very often (80–99%) | In 1 condition |
| TNFAIP3TNF alpha induced protein 3 | Very often (80–99%) | In 1 condition |
| TNFSF4TNF superfamily member 4 | Very often (80–99%) | In 1 condition |
| TNIP1TNFAIP3 interacting protein 1 | Very often (80–99%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Very often (80–99%) | In 1 condition |
| UBE2L3ubiquitin conjugating enzyme E2 L3 | Very often (80–99%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Often (30–79%) | In 2 conditions |
| P4HA2prolyl 4-hydroxylase subunit alpha 2 | Often (30–79%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| CTR9CTR9 component of Paf1/RNA polymerase II complex | Sometimes (5–29%) | In 1 condition |
| DIS3L2DIS3 like 3'-5' exoribonuclease 2 | Sometimes (5–29%) | In 1 condition |
| GPC3glypican 3 | Sometimes (5–29%) | In 1 condition |
| H19H19 imprinted maternally expressed transcript | Sometimes (5–29%) | In 1 condition |
Show 8 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| IL12Binterleukin 12B | Sometimes (5–29%) | In 1 condition |
| MLXMAX dimerization protein MLX | Sometimes (5–29%) | In 1 condition |
| POU6F2POU class 6 homeobox 2 | Sometimes (5–29%) | In 1 condition |
| RESTRE1 silencing transcription factor | Sometimes (5–29%) | In 1 condition |
| TRIM28tripartite motif containing 28 | Sometimes (5–29%) | In 1 condition |
| TRIP13thyroid hormone receptor interactor 13 | Sometimes (5–29%) | In 1 condition |
| WT1WT1 transcription factor | Sometimes (5–29%) | In 1 condition |
| ELANEelastase, neutrophil expressed | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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