Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Polyarticular arthritis, and the rest of your genome, with one test.
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Get my Genome Test50 genes linked to Polyarticular arthritis
Changes in these genes cause rare conditions in which Polyarticular arthritis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| MEFVMEFV innate immunity regulator, pyrin | Always | In 2 conditions |
| NLRP1NLR family pyrin domain containing 1 | Always | In 1 condition |
| NLRP3NLR family pyrin domain containing 3 | Always | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Always | In 1 condition |
| DMP1dentin matrix acidic phosphoprotein 1 | Very often (80–99%) | In 1 condition |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Very often (80–99%) | In 1 condition |
| NOD2nucleotide binding oligomerization domain containing 2 | Very often (80–99%) | In 1 condition |
| BANK1B cell scaffold protein with ankyrin repeats 1 | Often (30–79%) | In 1 condition |
| BLKBLK proto-oncogene, Src family tyrosine kinase | Often (30–79%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Often (30–79%) | In 1 condition |
| C4Bcomplement C4B (Chido/Rodgers blood group) | Often (30–79%) | In 1 condition |
| CR2complement C3d receptor 2 | Often (30–79%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Often (30–79%) | In 2 conditions |
| DNASE1deoxyribonuclease 1 | Often (30–79%) | In 1 condition |
| ETS1ETS proto-oncogene 1, transcription factor | Often (30–79%) | In 1 condition |
| FCGR2BFc gamma receptor IIb | Often (30–79%) | In 1 condition |
| FCGR3BFc gamma receptor IIIb | Often (30–79%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Often (30–79%) | In 1 condition |
| HLA-DPA1major histocompatibility complex, class II, DP alpha 1 | Often (30–79%) | In 1 condition |
| HLA-DPB1major histocompatibility complex, class II, DP beta 1 | Often (30–79%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Often (30–79%) | In 2 conditions |
| IGHG1immunoglobulin heavy constant gamma 1 (G1m marker) | Often (30–79%) | In 1 condition |
| IL10interleukin 10 | Often (30–79%) | In 2 conditions |
| IRAK1interleukin 1 receptor associated kinase 1 | Often (30–79%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Often (30–79%) | In 1 condition |
| ITGAMintegrin subunit alpha M | Often (30–79%) | In 1 condition |
| JAZF1JAZF zinc finger 1 | Often (30–79%) | In 1 condition |
| KIAA0319LKIAA0319 like | Often (30–79%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Often (30–79%) | In 1 condition |
| P4HA2prolyl 4-hydroxylase subunit alpha 2 | Often (30–79%) | In 1 condition |
| PDCD1programmed cell death 1 | Often (30–79%) | In 1 condition |
| PRTN3proteinase 3 | Often (30–79%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Often (30–79%) | In 3 conditions |
| PXKPX domain containing serine/threonine kinase like | Often (30–79%) | In 1 condition |
| SPP1secreted phosphoprotein 1 | Often (30–79%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Often (30–79%) | In 1 condition |
| TLR7toll like receptor 7 | Often (30–79%) | In 1 condition |
| TNFAIP3TNF alpha induced protein 3 | Often (30–79%) | In 2 conditions |
| TNFSF4TNF superfamily member 4 | Often (30–79%) | In 1 condition |
| TNIP1TNFAIP3 interacting protein 1 | Often (30–79%) | In 1 condition |
Show 10 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| TREX1three prime repair exonuclease 1 | Often (30–79%) | In 1 condition |
| UBE2L3ubiquitin conjugating enzyme E2 L3 | Often (30–79%) | In 1 condition |
| DOCK11dedicator of cytokinesis 11 | Sometimes (5–29%) | In 1 condition |
| IL36RNinterleukin 36 receptor antagonist | Sometimes (5–29%) | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Sometimes (5–29%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Rarely (1–4%) | In 1 condition |
| CD244CD244 molecule | Not recorded | In 1 condition |
| CIITAclass II major histocompatibility complex transactivator | Not recorded | In 1 condition |
| NFKBIL1NFKB inhibitor like 1 | Not recorded | In 1 condition |
| SLC22A4solute carrier family 22 member 4 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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