Trait
Intermittent claudication
Intermittent claudication is a symptom of peripheral arterial occlusive disease. After having walked over a distance which is individually characteristic, the patients experience pain or cramps in the calves, feet or thighs which typically subsides on standing still.
Summary
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test11 genes linked to Intermittent claudication
Changes in these genes cause rare conditions in which Intermittent claudication is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AEBP1AE binding protein 1 | Always | In 1 condition |
| NT5E5'-nucleotidase ecto | Always | In 1 condition |
| ABCC6ATP binding cassette subfamily C member 6 | Often (30–79%) | In 2 conditions |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Often (30–79%) | In 1 condition |
| IL12Binterleukin 12B | Often (30–79%) | In 1 condition |
| MLXMAX dimerization protein MLX | Often (30–79%) | In 1 condition |
| JAK2Janus kinase 2 | Sometimes (5–29%) | In 1 condition |
| XYLT1xylosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| XYLT2xylosyltransferase 2 | Sometimes (5–29%) | In 1 condition |
| AGXTalanine--glyoxylate aminotransferase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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