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Gene

CDSN

corneodesmosin

Summary

Cytogenetic location
6p21.33
Coordinates
Chromosome 6: 31,115,087–31,120,446 (GRCh38)
Exons
2 exons across 5.4 kb
Protein
529 amino acids
Also known as
D6S586E
MANE Select transcript
ENST00000376288.3NM_001264.5
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

  • Hereditary Hypotrichosis, Woolly Hair and Monilethrix

    • Hereditary hypotrichosis

      Sparse or absent scalp and body hair from childhood, including the LIPH- and LPAR6-related forms.

      • 1 GenCC submitter rates it definitive or strong

  • Inherited Ichthyoses

    • Peeling skin syndromeAutosomal recessive

      A group of conditions in which the outer layer of skin peels off easily, either over the whole body or mainly on the hands and feet.

      • 2 GenCC submitters rate it definitive or strong
      Actionability

      Avoiding friction, heat and moisture reduces peeling.

How CDSN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where CDSN sits. CDSN and 40 genes near it on chromosome 6, from 30,617,767 to 31,617,766.Chromosome 66p21.33p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2730.8 Mb31 Mb31.2 Mb31.4 Mb31.6 MbPPP1R10: 30,600,400–30,618,612, reverse strandMRPS18B: 30,617,759–30,626,398, forward strandMRPS18BATAT1: 30,626,837–30,646,835, forward strandATAT1C6orf136: 30,647,003–30,653,225, forward strandDHX16: 30,652,469–30,673,059, reverse strandDHX16PPP1R18: 30,676,389–30,687,895, reverse strandNRM: 30,688,047–30,691,420, reverse strandNRMMDC1: 30,699,807–30,717,562, reverse strandMDC1TUBB: 30,717,435–30,725,538, forward strandTUBBFLOT1: 30,727,709–30,743,075, reverse strandFLOT1IER3: 30,743,199–30,744,555, reverse strandIER3DDR1: 30,876,421–30,900,978, forward strandDDR1GTF2H4: 30,907,517–30,914,119, forward strandVARS2: 30,914,205–30,928,614, forward strandVARS2SFTA2: 30,931,353–30,955,636, reverse strandSFTA2SFTA2-AS1: 30,934,523–30,938,824, forward strandSFTA2-AS1MUCL3: 30,940,973–30,954,221, forward strandMUCL3MUC21: 30,983,718–30,989,903, forward strandMUC21MUC22: 31,010,474–31,036,882, forward strandMUC22C6orf15: 31,111,223–31,112,582, reverse strandC6orf15PSORS1C1: 31,114,750–31,140,092, forward strandPSORS1C1CDSN: 31,115,087–31,120,446, reverse strandCDSNPSORS1C2: 31,137,534–31,139,721, reverse strandPSORS1C2CCHCR1: 31,142,439–31,158,238, reverse strandTCF19: 31,158,331–31,167,252, forward strandPOU5F1: 31,163,193–31,180,731, reverse strandHLA-C: 31,268,746–31,272,171, reverse strandHLA-CHLA-B: 31,353,195–31,367,067, reverse strandHLA-BMICA: 31,399,784–31,415,315, forward strandMICAMICB: 31,494,881–31,511,124, forward strandMICBMCCD1: 31,528,962–31,530,232, forward strandMCCD1DDX39B: 31,530,217–31,542,451, reverse strandDDX39BATP6V1G2-DDX39B: 31,530,219–31,546,608, reverse strandATP6V1G2-DDX39BATP6V1G2: 31,544,444–31,548,427, reverse strandNFKBIL1: 31,546,870–31,558,829, forward strandLTA: 31,572,054–31,574,324, forward strandTNF: 31,575,558–31,578,336, forward strandTNFLTB: 31,580,525–31,582,522, reverse strandLST1: 31,581,065–31,588,911, forward strandNCR3: 31,588,895–31,593,217, reverse strandAIF1: 31,615,214–31,617,025, forward strandAIF1Diagram of CDSN: 2 exons on the reverse strand of chromosome 6Exon 2: 2 known disease-causing sitesExon 1: 1 known disease-causing siteExon 2: 31,115,087–31,117,529, 2,443 basesExon 1: 31,120,335–31,120,446, 112 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.6 kb of the gene's 5.4 kb; 1,590 of those bases code for the protein.

Sequencing CDSN

2Low

How hard CDSN is to sequence with short reads, out of 100

  • Mappability0%
  • Homology0%
  • Repeats6%
  • GC content13%
  • Reference coverage0%

3

positions in CDSN where ClinVar classes a change as pathogenic or likely pathogenic

3 of them (100%) fall in regions short reads find hard.

  • MHC (3 sites)

A whole genome covers all 5.4 kb of CDSN, introns included, not only the 2.6 kb of exons.

Genes linked to the same conditions

Traits linked to CDSN

The Human Phenotype Ontology lists these as features of the rare conditions CDSN can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). CDSN gene: corneodesmosin. Retrieved 18 October 2026, from https://dantelabs.com/genes/cdsn

Vancouver

Dante Labs. CDSN gene: corneodesmosin [Internet]. [cited 18 October 2026]. Available from: https://dantelabs.com/genes/cdsn

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