Trait
Weakness of muscles controlling eye movement
Clinical name: Ophthalmoparesis
Ophthalmoplegia is a paralysis or weakness of one or more of the muscles that control eye movement.
Summary
- Also called
- Extraocular muscle palsy, Extraocular muscle paralysis, Weakness of extraocular eye movement
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
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Get my Genome Test80 genes linked to Weakness of muscles controlling eye movement
Changes in these genes cause rare conditions in which Weakness of muscles controlling eye movement is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AFG3L2AFG3 like matrix AAA peptidase subunit 2 | Always | In 3 conditions |
| CHRNEcholinergic receptor nicotinic epsilon subunit | Always | In 2 conditions |
| COX10cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 | Always | In 1 condition |
| COX15cytochrome c oxidase assembly factor COX15 | Always | In 1 condition |
| COX6B1cytochrome c oxidase subunit 6B1 | Always | In 1 condition |
| FASTKD2FASTK mitochondrial RNA regulator 2 | Always | In 1 condition |
| GFPT1glutamine--fructose-6-phosphate transaminase 1 | Always | In 2 conditions |
| ISCUiron-sulfur cluster assembly enzyme | Always | In 1 condition |
| JPH1junctophilin 1 | Always | In 1 condition |
| MT-TNmitochondrially encoded tRNA-Asn (AAU/C) | Always | In 1 condition |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Always | In 1 condition |
| MUSKmuscle associated receptor tyrosine kinase | Always | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Always | In 6 conditions |
| SCO1synthesis of cytochrome C oxidase 1 | Always | In 1 condition |
| SCO2synthesis of cytochrome C oxidase 2 | Always | In 1 condition |
| SLC5A7solute carrier family 5 member 7 | Always | In 1 condition |
| SURF1SURF1 cytochrome c oxidase assembly factor | Always | In 1 condition |
| TACO1translational activator of cytochrome c oxidase I | Always | In 1 condition |
| TEFMtranscription elongation factor, mitochondrial | Always | In 1 condition |
| TUBA4Atubulin alpha 4a | Always | In 1 condition |
| TYMPthymidine phosphorylase | Always | In 2 conditions |
| ABCD3ATP binding cassette subfamily D member 3 | Very often (80–99%) | In 1 condition |
| GIPC1GIPC PDZ domain containing family member 1 | Very often (80–99%) | In 1 condition |
| LRP12LDL receptor related protein 12 | Very often (80–99%) | In 2 conditions |
| NOTCH2NLCnotch 2 N-terminal like C | Very often (80–99%) | In 1 condition |
| NUTM2B-AS1NUTM2B antisense RNA 1 | Very often (80–99%) | In 1 condition |
| PLECplectin | Very often (80–99%) | In 1 condition |
| RILPL1Rab interacting lysosomal protein like 1 | Very often (80–99%) | In 1 condition |
| ATN1atrophin 1 | Often (30–79%) | In 1 condition |
| ATXN7ataxin 7 | Often (30–79%) | In 1 condition |
| COL13A1collagen type XIII alpha 1 chain | Often (30–79%) | In 1 condition |
| COLQcollagen like tail subunit of asymmetric acetylcholinesterase | Often (30–79%) | In 2 conditions |
| DNM2dynamin 2 | Often (30–79%) | In 1 condition |
| GUK1guanylate kinase 1 | Often (30–79%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Often (30–79%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Often (30–79%) | In 1 condition |
| LAMB2laminin subunit beta 2 | Often (30–79%) | In 1 condition |
| LIG3DNA ligase 3 | Often (30–79%) | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Often (30–79%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Often (30–79%) | In 1 condition |
Show 40 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Often (30–79%) | In 1 condition |
| MT-ND2mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 | Often (30–79%) | In 1 condition |
| MT-ND3mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 | Often (30–79%) | In 1 condition |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Often (30–79%) | In 1 condition |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Often (30–79%) | In 1 condition |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Often (30–79%) | In 1 condition |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Often (30–79%) | In 2 conditions |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Often (30–79%) | In 1 condition |
| MT-TVmitochondrially encoded tRNA-Val (GUN) | Often (30–79%) | In 1 condition |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Often (30–79%) | In 1 condition |
| MTMR14myotubularin related protein 14 | Often (30–79%) | In 1 condition |
| P4HA2prolyl 4-hydroxylase subunit alpha 2 | Often (30–79%) | In 1 condition |
| POLG2DNA polymerase gamma 2, accessory subunit | Often (30–79%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Often (30–79%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Often (30–79%) | In 2 conditions |
| SLC25A4solute carrier family 25 member 4 | Often (30–79%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Often (30–79%) | In 3 conditions |
| UCHL1ubiquitin C-terminal hydrolase L1 | Often (30–79%) | In 1 condition |
| ALDH4A1aldehyde dehydrogenase 4 family member A1 | Sometimes (5–29%) | In 1 condition |
| ATXN1ataxin 1 | Sometimes (5–29%) | In 1 condition |
| ATXN2ataxin 2 | Sometimes (5–29%) | In 1 condition |
| BIN1bridging integrator 1 | Sometimes (5–29%) | In 1 condition |
| DNA2DNA replication helicase/nuclease 2 | Sometimes (5–29%) | In 1 condition |
| DOK7docking protein 7 | Sometimes (5–29%) | In 1 condition |
| GSNgelsolin | Sometimes (5–29%) | In 1 condition |
| KLHL40kelch like family member 40 | Sometimes (5–29%) | In 1 condition |
| RNASEH1ribonuclease H1 | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Sometimes (5–29%) | In 3 conditions |
| SPEGstriated muscle enriched protein kinase | Sometimes (5–29%) | In 1 condition |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Sometimes (5–29%) | In 1 condition |
| TTNtitin | Sometimes (5–29%) | In 1 condition |
| CACNA1Scalcium voltage-gated channel subunit alpha1 S | Rarely (1–4%) | In 1 condition |
| GABRA3gamma-aminobutyric acid type A receptor subunit alpha3 | Rarely (1–4%) | In 1 condition |
| KCNJ18potassium inwardly rectifying channel subfamily J member 18 | Rarely (1–4%) | In 1 condition |
| ACTN2actinin alpha 2 | Not recorded | In 1 condition |
| CHATcholine O-acetyltransferase | Not recorded | In 1 condition |
| CHRNA1cholinergic receptor nicotinic alpha 1 subunit | Not recorded | In 2 conditions |
| MAPTmicrotubule associated protein tau | Not recorded | In 1 condition |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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