Trait
Flat, discolored area of skin
Clinical name: Macule
A flat, distinct, discolored area of skin less than 1 cm wide that does not involve any change in the thickness or texture of the skin.
Summary
- Also called
- Flat, discoloured area of skin
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Flat, discolored area of skin, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test67 genes linked to Flat, discolored area of skin
Changes in these genes cause rare conditions in which Flat, discolored area of skin is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ADAM10ADAM metallopeptidase domain 10 | Always | In 1 condition |
| GGCXgamma-glutamyl carboxylase | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| SMARCAL1SNF2 related chromatin remodeling annealing helicase 1 | Always | In 1 condition |
| ABCB6ATP binding cassette subfamily B member 6 (LAN blood group) | Very often (80–99%) | In 1 condition |
| ACDACD shelterin complex subunit and telomerase recruitment factor | Very often (80–99%) | In 1 condition |
| ADARadenosine deaminase RNA specific | Very often (80–99%) | In 1 condition |
| CTC1CST telomere replication complex component 1 | Very often (80–99%) | In 1 condition |
| CYBAcytochrome b-245 alpha chain | Very often (80–99%) | In 1 condition |
| CYBBcytochrome b-245 beta chain | Very often (80–99%) | In 1 condition |
| CYBC1cytochrome b-245 chaperone 1 | Very often (80–99%) | In 1 condition |
| DKC1dyskerin pseudouridine synthase 1 | Very often (80–99%) | In 1 condition |
| ELOVL4ELOVL fatty acid elongase 4 | Very often (80–99%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Very often (80–99%) | In 1 condition |
| GJB3gap junction protein beta 3 | Very often (80–99%) | In 1 condition |
| GJB4gap junction protein beta 4 | Very often (80–99%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Very often (80–99%) | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Very often (80–99%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Very often (80–99%) | In 1 condition |
| IKZF1IKAROS family zinc finger 1 | Very often (80–99%) | In 1 condition |
| KDSR3-ketodihydrosphingosine reductase | Very often (80–99%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Very often (80–99%) | In 1 condition |
| NCF2neutrophil cytosolic factor 2 | Very often (80–99%) | In 1 condition |
| NCF4neutrophil cytosolic factor 4 | Very often (80–99%) | In 1 condition |
| NHP2NHP2 ribonucleoprotein | Very often (80–99%) | In 1 condition |
| NOP10NOP10 ribonucleoprotein | Very often (80–99%) | In 1 condition |
| NPM1nucleophosmin 1 | Very often (80–99%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Very often (80–99%) | In 1 condition |
| PTENphosphatase and tensin homolog | Very often (80–99%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Very often (80–99%) | In 1 condition |
| STK11serine/threonine kinase 11 | Very often (80–99%) | In 1 condition |
| TERCtelomerase RNA component | Very often (80–99%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Very often (80–99%) | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Very often (80–99%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Very often (80–99%) | In 1 condition |
| TYMSthymidylate synthetase | Very often (80–99%) | In 1 condition |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Very often (80–99%) | In 1 condition |
| WRAP53WD repeat containing antisense to TP53 | Very often (80–99%) | In 1 condition |
| DDB2damage specific DNA binding protein 2 | Often (30–79%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Often (30–79%) | In 1 condition |
Show 27 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Often (30–79%) | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Often (30–79%) | In 1 condition |
| ERCC5ERCC excision repair 5, endonuclease | Often (30–79%) | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Often (30–79%) | In 2 conditions |
| SNAI2snail family transcriptional repressor 2 | Often (30–79%) | In 1 condition |
| XPAXPA, DNA damage recognition and repair factor | Often (30–79%) | In 1 condition |
| XPCXPC complex subunit, DNA damage recognition and repair factor | Often (30–79%) | In 1 condition |
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Sometimes (5–29%) | In 1 condition |
| CASZ1castor zinc finger 1 | Sometimes (5–29%) | In 1 condition |
| CSTAcystatin A | Sometimes (5–29%) | In 1 condition |
| GABRDgamma-aminobutyric acid type A receptor subunit delta | Sometimes (5–29%) | In 1 condition |
| GNASGNAS complex locus | Sometimes (5–29%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Sometimes (5–29%) | In 1 condition |
| KCNAB2potassium voltage-gated channel subfamily A regulatory beta subunit 2 | Sometimes (5–29%) | In 1 condition |
| LUZP1leucine zipper protein 1 | Sometimes (5–29%) | In 1 condition |
| MMP23Bmatrix metallopeptidase 23B | Sometimes (5–29%) | In 1 condition |
| PDPNpodoplanin | Sometimes (5–29%) | In 1 condition |
| PRDM16PR/SET domain 16 | Sometimes (5–29%) | In 1 condition |
| PRKCZprotein kinase C zeta | Sometimes (5–29%) | In 1 condition |
| REREarginine-glutamic acid dipeptide repeats | Sometimes (5–29%) | In 1 condition |
| SKISKI proto-oncogene | Sometimes (5–29%) | In 1 condition |
| SPENspen family transcriptional repressor | Sometimes (5–29%) | In 1 condition |
| TGM5transglutaminase 5 | Sometimes (5–29%) | In 1 condition |
| TSC1TSC complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| TSC2TSC complex subunit 2 | Sometimes (5–29%) | In 1 condition |
| UBE4Bubiquitination factor E4B | Sometimes (5–29%) | In 1 condition |
| NF1neurofibromin 1 | Rarely (1–4%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks