Trait
High urine protein levels
Clinical name: Proteinuria
Increased levels of protein in the urine.
Summary
- Also called
- Protein in urine
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to High urine protein levels, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test250 genes linked to High urine protein levels
Changes in these genes cause rare conditions in which High urine protein levels is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACTN4actinin alpha 4 | Always | In 2 conditions |
| ANKFY1ankyrin repeat and FYVE domain containing 1 | Always | In 1 condition |
| ANLNanillin, actin binding protein | Always | In 2 conditions |
| APOA1apolipoprotein A1 | Always | In 1 condition |
| APOL1apolipoprotein L1 | Always | In 1 condition |
| APTXaprataxin | Always | In 1 condition |
| ARHGAP24Rho GTPase activating protein 24 | Always | In 1 condition |
| ARHGDIARho GDP dissociation inhibitor alpha | Always | In 2 conditions |
| AVILadvillin | Always | In 1 condition |
| CD2APCD2 associated protein | Always | In 2 conditions |
| CLDN16claudin 16 | Always | In 1 condition |
| COL4A3collagen type IV alpha 3 chain | Always | In 6 conditions |
| COL6A1collagen type VI alpha 1 chain | Always | In 1 condition |
| COQ2coenzyme Q2, polyprenyltransferase | Always | In 1 condition |
| COQ8Bcoenzyme Q8B | Always | In 2 conditions |
| CRB2crumbs cell polarity complex component 2 | Always | In 1 condition |
| CTNScystinosin, lysosomal cystine transporter | Always | In 3 conditions |
| CUBNcubilin | Always | In 3 conditions |
| DAAM2dishevelled associated activator of morphogenesis 2 | Always | In 1 condition |
| DGKEdiacylglycerol kinase epsilon | Always | In 2 conditions |
| DNASE2deoxyribonuclease 2, lysosomal | Always | In 1 condition |
| EMP2epithelial membrane protein 2 | Always | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Always | In 2 conditions |
| FN1fibronectin 1 | Always | In 2 conditions |
| GAPVD1GTPase activating protein and VPS9 domains 1 | Always | In 1 condition |
| HMOX1heme oxygenase 1 | Always | In 2 conditions |
| HNF4Ahepatocyte nuclear factor 4 alpha | Always | In 2 conditions |
| IFT172intraflagellar transport 172 | Always | In 1 condition |
| INF2inverted formin 2 | Always | In 3 conditions |
| KANK2KN motif and ankyrin repeat domains 2 | Always | In 2 conditions |
| KIRREL1kirre like nephrin family adhesion molecule 1 | Always | In 1 condition |
| LAGE3L antigen family member 3 | Always | In 2 conditions |
| LAMA5laminin subunit alpha 5 | Always | In 1 condition |
| LAMB2laminin subunit beta 2 | Always | In 2 conditions |
| LCATlecithin-cholesterol acyltransferase | Always | In 1 condition |
| LRP2LDL receptor related protein 2 | Always | In 2 conditions |
| MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2 | Always | In 2 conditions |
| MEFVMEFV innate immunity regulator, pyrin | Always | In 2 conditions |
| MYO1Emyosin IE | Always | In 2 conditions |
| NPHS1NPHS1 adhesion molecule, nephrin | Always | In 3 conditions |
Show 210 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| NPHS2NPHS2 stomatin family member, podocin | Always | In 2 conditions |
| NUP107nucleoporin 107 | Always | In 4 conditions |
| NUP133nucleoporin 133 | Always | In 4 conditions |
| NUP160nucleoporin 160 | Always | In 2 conditions |
| NUP205nucleoporin 205 | Always | In 1 condition |
| NUP37nucleoporin 37 | Always | In 1 condition |
| NUP85nucleoporin 85 | Always | In 2 conditions |
| NUP93nucleoporin 93 | Always | In 1 condition |
| PAX2paired box 2 | Always | In 4 conditions |
| PDSS2decaprenyl diphosphate synthase subunit 2 | Always | In 1 condition |
| PLCE1phospholipase C epsilon 1 | Always | In 2 conditions |
| PLD4phospholipase D family member 4 | Always | In 1 condition |
| PTPROprotein tyrosine phosphatase receptor type O | Always | In 2 conditions |
| SCARB2scavenger receptor class B member 2 | Always | In 1 condition |
| SLC34A1solute carrier family 34 member 1 | Always | In 1 condition |
| STAT2signal transducer and activator of transcription 2 | Always | In 1 condition |
| TBC1D8BTBC1 domain family member 8B | Always | In 2 conditions |
| TP53RKTP53 regulating kinase | Always | In 2 conditions |
| TPRKBTP53RK binding protein | Always | In 2 conditions |
| TRPC6transient receptor potential cation channel subfamily C member 6 | Always | In 2 conditions |
| VIPAS39VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | Always | In 1 condition |
| VPS33AVPS33A core subunit of CORVET and HOPS complexes | Always | In 2 conditions |
| VPS33BVPS33B late endosome and lysosome associated | Always | In 1 condition |
| WDR19WD repeat domain 19 | Always | In 2 conditions |
| WSB2WD repeat and SOCS box containing 2 | Always | In 1 condition |
| WT1WT1 transcription factor | Always | In 4 conditions |
| YRDCyrdC N6-threonylcarbamoyltransferase domain containing | Always | In 2 conditions |
| ZAP70zeta chain of T cell receptor associated protein kinase 70 | Always | In 1 condition |
| ACSL4acyl-CoA synthetase long chain family member 4 | Very often (80–99%) | In 1 condition |
| AMMECR1AMMECR nuclear protein 1 | Very often (80–99%) | In 1 condition |
| AMNamnion associated transmembrane protein | Very often (80–99%) | In 2 conditions |
| BANK1B cell scaffold protein with ankyrin repeats 1 | Very often (80–99%) | In 1 condition |
| BLKBLK proto-oncogene, Src family tyrosine kinase | Very often (80–99%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Very often (80–99%) | In 1 condition |
| C4Bcomplement C4B (Chido/Rodgers blood group) | Very often (80–99%) | In 1 condition |
| COL4A4collagen type IV alpha 4 chain | Very often (80–99%) | In 4 conditions |
| COL4A5collagen type IV alpha 5 chain | Very often (80–99%) | In 3 conditions |
| CORINcorin, serine peptidase | Very often (80–99%) | In 1 condition |
| CR2complement C3d receptor 2 | Very often (80–99%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Very often (80–99%) | In 2 conditions |
| DNASE1deoxyribonuclease 1 | Very often (80–99%) | In 1 condition |
| ETS1ETS proto-oncogene 1, transcription factor | Very often (80–99%) | In 1 condition |
| FCGR2BFc gamma receptor IIb | Very often (80–99%) | In 1 condition |
| FCGR3BFc gamma receptor IIIb | Very often (80–99%) | In 1 condition |
| FLT1fms related receptor tyrosine kinase 1 | Very often (80–99%) | In 1 condition |
| GON7GON7 subunit of KEOPS complex | Very often (80–99%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Very often (80–99%) | In 1 condition |
| IFT140intraflagellar transport 140 | Very often (80–99%) | In 2 conditions |
| IGHG1immunoglobulin heavy constant gamma 1 (G1m marker) | Very often (80–99%) | In 1 condition |
| IL10interleukin 10 | Very often (80–99%) | In 1 condition |
| IRAK1interleukin 1 receptor associated kinase 1 | Very often (80–99%) | In 2 conditions |
| IRF5interferon regulatory factor 5 | Very often (80–99%) | In 1 condition |
| ITGAMintegrin subunit alpha M | Very often (80–99%) | In 1 condition |
| JAZF1JAZF zinc finger 1 | Very often (80–99%) | In 1 condition |
| KCNE5potassium voltage-gated channel subfamily E regulatory subunit 5 | Very often (80–99%) | In 1 condition |
| KIAA0319LKIAA0319 like | Very often (80–99%) | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Very often (80–99%) | In 4 conditions |
| MAFBMAF bZIP transcription factor B | Very often (80–99%) | In 2 conditions |
| MECP2methyl-CpG binding protein 2 | Very often (80–99%) | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Very often (80–99%) | In 1 condition |
| OSGEPO-sialoglycoprotein endopeptidase | Very often (80–99%) | In 2 conditions |
| PDCD1programmed cell death 1 | Very often (80–99%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Very often (80–99%) | In 2 conditions |
| PXKPX domain containing serine/threonine kinase like | Very often (80–99%) | In 1 condition |
| SAA1serum amyloid A1 | Very often (80–99%) | In 1 condition |
| SMARCAL1SNF2 related chromatin remodeling annealing helicase 1 | Very often (80–99%) | In 2 conditions |
| SPP1secreted phosphoprotein 1 | Very often (80–99%) | In 2 conditions |
| STAT4signal transducer and activator of transcription 4 | Very often (80–99%) | In 2 conditions |
| STOX1storkhead box 1 | Very often (80–99%) | In 1 condition |
| TLR7toll like receptor 7 | Very often (80–99%) | In 1 condition |
| TNFAIP3TNF alpha induced protein 3 | Very often (80–99%) | In 1 condition |
| TNFSF4TNF superfamily member 4 | Very often (80–99%) | In 1 condition |
| TNIP1TNFAIP3 interacting protein 1 | Very often (80–99%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Very often (80–99%) | In 3 conditions |
| UBE2L3ubiquitin conjugating enzyme E2 L3 | Very often (80–99%) | In 1 condition |
| WDR4WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit | Very often (80–99%) | In 2 conditions |
| WDR73WD repeat domain 73 | Very often (80–99%) | In 2 conditions |
| APRTadenine phosphoribosyltransferase | Often (30–79%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Often (30–79%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Often (30–79%) | In 1 condition |
| C1GALT1C1C1GALT1 specific chaperone 1 | Often (30–79%) | In 1 condition |
| CD46CD46 molecule | Often (30–79%) | In 2 conditions |
| CFHcomplement factor H | Often (30–79%) | In 1 condition |
| CFIcomplement factor I | Often (30–79%) | In 2 conditions |
| CLIP2CAP-Gly domain containing linker protein 2 | Often (30–79%) | In 1 condition |
| COA8cytochrome c oxidase assembly factor 8 | Often (30–79%) | In 1 condition |
| COL4A6collagen type IV alpha 6 chain | Often (30–79%) | In 1 condition |
| DLSTdihydrolipoamide S-succinyltransferase | Often (30–79%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Often (30–79%) | In 1 condition |
| DNASE1L3deoxyribonuclease 1L3 | Often (30–79%) | In 1 condition |
| DNMT3ADNA methyltransferase 3 alpha | Often (30–79%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Often (30–79%) | In 1 condition |
| ELNelastin | Often (30–79%) | In 1 condition |
| EPAS1endothelial PAS domain protein 1 | Often (30–79%) | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Often (30–79%) | In 2 conditions |
| ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Often (30–79%) | In 2 conditions |
| EXT2exostosin glycosyltransferase 2 | Often (30–79%) | In 1 condition |
| FAN1FANCD2 and FANCI associated nuclease 1 | Often (30–79%) | In 1 condition |
| FHfumarate hydratase | Often (30–79%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Often (30–79%) | In 1 condition |
| GLAgalactosidase alpha | Often (30–79%) | In 2 conditions |
| GTF2Igeneral transcription factor IIi | Often (30–79%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Often (30–79%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Often (30–79%) | In 1 condition |
| HELLPARHELLP associated long non-coding RNA | Often (30–79%) | In 1 condition |
| HLA-DPA1major histocompatibility complex, class II, DP alpha 1 | Often (30–79%) | In 1 condition |
| HLA-DPB1major histocompatibility complex, class II, DP beta 1 | Often (30–79%) | In 1 condition |
| HNF1BHNF1 homeobox B | Often (30–79%) | In 1 condition |
| KIF1Bkinesin family member 1B | Often (30–79%) | In 2 conditions |
| LIMK1LIM domain kinase 1 | Often (30–79%) | In 1 condition |
| LYZlysozyme | Often (30–79%) | In 1 condition |
| MAXMYC associated transcriptional regulator X | Often (30–79%) | In 2 conditions |
| MDH2malate dehydrogenase 2 | Often (30–79%) | In 1 condition |
| METTL27methyltransferase like 27 | Often (30–79%) | In 1 condition |
| MTX2metaxin 2 | Often (30–79%) | In 1 condition |
| MYH9myosin heavy chain 9 | Often (30–79%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Often (30–79%) | In 1 condition |
| NF1neurofibromin 1 | Often (30–79%) | In 1 condition |
| PBX1PBX homeobox 1 | Often (30–79%) | In 1 condition |
| PRODHproline dehydrogenase 1 | Often (30–79%) | In 1 condition |
| PRTN3proteinase 3 | Often (30–79%) | In 1 condition |
| PUS3pseudouridine synthase 3 | Often (30–79%) | In 1 condition |
| RETret proto-oncogene | Often (30–79%) | In 3 conditions |
| RFC2replication factor C subunit 2 | Often (30–79%) | In 1 condition |
| SARS2seryl-tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| SAT1spermidine/spermine N1-acetyltransferase 1 | Often (30–79%) | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Often (30–79%) | In 1 condition |
| SDHAF2succinate dehydrogenase complex assembly factor 2 | Often (30–79%) | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Often (30–79%) | In 2 conditions |
| SDHCsuccinate dehydrogenase complex subunit C | Often (30–79%) | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Often (30–79%) | In 2 conditions |
| SH2B1SH2B adaptor protein 1 | Often (30–79%) | In 1 condition |
| SLC22A12solute carrier family 22 member 12 | Often (30–79%) | In 1 condition |
| SLC25A11solute carrier family 25 member 11 | Often (30–79%) | In 1 condition |
| SLC2A2solute carrier family 2 member 2 | Often (30–79%) | In 1 condition |
| SLC7A7solute carrier family 7 member 7 | Often (30–79%) | In 1 condition |
| STX1Asyntaxin 1A | Often (30–79%) | In 1 condition |
| TBL2transducin beta like 2 | Often (30–79%) | In 1 condition |
| TMEM127transmembrane protein 127 | Often (30–79%) | In 2 conditions |
| TMEM270transmembrane protein 270 | Often (30–79%) | In 1 condition |
| TRIM8tripartite motif containing 8 | Often (30–79%) | In 1 condition |
| UMODuromodulin | Often (30–79%) | In 1 condition |
| VHLvon Hippel-Lindau tumor suppressor | Often (30–79%) | In 3 conditions |
| VPS37DVPS37D subunit of ESCRT-I | Often (30–79%) | In 1 condition |
| ACP5acid phosphatase 5, tartrate resistant | Sometimes (5–29%) | In 1 condition |
| ADA2adenosine deaminase 2 | Sometimes (5–29%) | In 1 condition |
| BNC2basonuclin zinc finger protein 2 | Sometimes (5–29%) | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Sometimes (5–29%) | In 1 condition |
| DPH1diphthamide biosynthesis 1 | Sometimes (5–29%) | In 1 condition |
| FOXC2forkhead box C2 | Sometimes (5–29%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Sometimes (5–29%) | In 1 condition |
| GSNgelsolin | Sometimes (5–29%) | In 1 condition |
| LMNB2lamin B2 | Sometimes (5–29%) | In 2 conditions |
| LPIN2lipin 2 | Sometimes (5–29%) | In 1 condition |
| MAFMAF bZIP transcription factor | Sometimes (5–29%) | In 1 condition |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Sometimes (5–29%) | In 1 condition |
| MT-CO2mitochondrially encoded cytochrome c oxidase II | Sometimes (5–29%) | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Sometimes (5–29%) | In 1 condition |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Sometimes (5–29%) | In 1 condition |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Sometimes (5–29%) | In 1 condition |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Sometimes (5–29%) | In 1 condition |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Sometimes (5–29%) | In 1 condition |
| MT-TFmitochondrially encoded tRNA-Phe (UUU/C) | Sometimes (5–29%) | In 1 condition |
| MT-THmitochondrially encoded tRNA-His (CAU/C) | Sometimes (5–29%) | In 1 condition |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Sometimes (5–29%) | In 1 condition |
| MT-TQmitochondrially encoded tRNA-Gln (CAA/G) | Sometimes (5–29%) | In 1 condition |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Sometimes (5–29%) | In 2 conditions |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Sometimes (5–29%) | In 1 condition |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Sometimes (5–29%) | In 1 condition |
| NIPBLNIPBL cohesin loading factor | Sometimes (5–29%) | In 1 condition |
| OFD1OFD1 centriole and centriolar satellite protein | Sometimes (5–29%) | In 2 conditions |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Sometimes (5–29%) | In 1 condition |
| PMM2phosphomannomutase 2 | Sometimes (5–29%) | In 2 conditions |
| PSTPIP1proline-serine-threonine phosphatase interacting protein 1 | Sometimes (5–29%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Sometimes (5–29%) | In 1 condition |
| SLC37A4solute carrier family 37 member 4 | Sometimes (5–29%) | In 3 conditions |
| SNAP29synaptosome associated protein 29 | Sometimes (5–29%) | In 1 condition |
| SPRY2sprouty RTK signaling antagonist 2 | Sometimes (5–29%) | In 1 condition |
| UNC45Aunc-45 myosin chaperone A | Sometimes (5–29%) | In 1 condition |
| PYGLglycogen phosphorylase L | Rarely (1–4%) | In 1 condition |
| ADAMTS13ADAM metallopeptidase with thrombospondin type 1 motif 13 | Not recorded | In 1 condition |
| APOEapolipoprotein E | Not recorded | In 1 condition |
| ATP7BATPase copper transporting beta | Not recorded | In 1 condition |
| C3complement C3 | Not recorded | In 1 condition |
| CFBcomplement factor B | Not recorded | In 1 condition |
| COQ6coenzyme Q6, monooxygenase | Not recorded | In 1 condition |
| COX10cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 | Not recorded | In 1 condition |
| COX15cytochrome c oxidase assembly factor COX15 | Not recorded | In 1 condition |
| COX6B1cytochrome c oxidase subunit 6B1 | Not recorded | In 1 condition |
| FASTKD2FASTK mitochondrial RNA regulator 2 | Not recorded | In 1 condition |
| FGAfibrinogen alpha chain | Not recorded | In 1 condition |
| G6PC1glucose-6-phosphatase catalytic subunit 1 | Not recorded | In 1 condition |
| GATA3GATA binding protein 3 | Not recorded | In 1 condition |
| ITGA3integrin subunit alpha 3 | Not recorded | In 1 condition |
| ITGA8integrin subunit alpha 8 | Not recorded | In 1 condition |
| MMACHCmetabolism of cobalamin associated C | Not recorded | In 1 condition |
| MT-TNmitochondrially encoded tRNA-Asn (AAU/C) | Not recorded | In 1 condition |
| NDUFAF6NADH:ubiquinone oxidoreductase complex assembly factor 6 | Not recorded | In 1 condition |
| NEU1neuraminidase 1 | Not recorded | In 1 condition |
| NOTCH2notch receptor 2 | Not recorded | In 1 condition |
| PRDX1peroxiredoxin 1 | Not recorded | In 1 condition |
| RENrenin | Not recorded | In 1 condition |
| SCO1synthesis of cytochrome C oxidase 1 | Not recorded | In 1 condition |
| SCO2synthesis of cytochrome C oxidase 2 | Not recorded | In 1 condition |
| SGPL1sphingosine-1-phosphate lyase 1 | Not recorded | In 1 condition |
| SLC35A1solute carrier family 35 member A1 | Not recorded | In 1 condition |
| SURF1SURF1 cytochrome c oxidase assembly factor | Not recorded | In 1 condition |
| TACO1translational activator of cytochrome c oxidase I | Not recorded | In 1 condition |
| THBDthrombomodulin | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks