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Gene

APOE

apolipoprotein E

Summary

Cytogenetic location
19q13.32
Coordinates
Chromosome 19: 44,905,796–44,909,393 (GRCh38)
Exons
4 exons across 3.6 kb
Protein
317 amino acids
Previous symbols
AD2
MANE Select transcript
ENST00000252486.9NM_000041.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Alzheimer disease

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Enhanced screening, cognitive engagement, cardiovascular health optimization, anti-amyloid therapies (lecanemab), prevention trial eligibility

  • Hyperlipidemia

      • 2 GenCC submitters rate it definitive or strong

How APOE is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where APOE sits. APOE and 33 genes near it on chromosome 19, from 44,407,595 to 45,407,594.Chromosome 1919q13.32p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4344.6 Mb44.8 Mb45 Mb45.2 Mb45.4 MbZNF229: 44,417,519–44,448,578, reverse strandZNF229ZNF180: 44,470,957–44,500,547, reverse strandZNF180CEACAM20: 44,501,677–44,529,788, reverse strandCEACAM20IGSF23: 44,613,563–44,636,787, forward strandIGSF23PVR: 44,643,798–44,666,162, forward strandPVRCEACAM19: 44,662,278–44,684,370, forward strandCEACAM19CEACAM16: 44,699,151–44,710,718, forward strandCEACAM16BCL3: 44,747,705–44,760,044, forward strandBCL3CBLC: 44,777,845–44,802,301, forward strandCBLCBCAM: 44,809,040–44,821,421, forward strandBCAMNECTIN2: 44,846,175–44,890,134, forward strandNECTIN2TOMM40: 44,890,569–44,903,695, forward strandTOMM40APOE: 44,905,796–44,909,393, forward strandAPOEAPOC1: 44,913,133–44,920,054, forward strandAPOC1APOC2: 44,936,126–44,949,585, forward strandAPOC2APOC4: 44,942,234–44,945,496, forward strandAPOC4-APOC2: 44,942,238–44,949,565, forward strandCLPTM1: 44,954,585–44,993,342, forward strandCLPTM1RELB: 45,001,431–45,038,194, forward strandRELBCLASRP: 45,039,042–45,070,956, forward strandCLASRPZNF296: 45,071,500–45,076,485, reverse strandZNF296GEMIN7: 45,075,575–45,091,518, forward strandGEMIN7MARK4: 45,079,288–45,305,284, forward strandPPP1R37: 45,091,396–45,148,077, forward strandPPP1R37NKPD1: 45,149,744–45,160,982, reverse strandNKPD1BLOC1S3: 45,152,811–45,216,933, forward strandBLOC1S3TRAPPC6A: 45,162,928–45,178,268, reverse strandTRAPPC6AEXOC3L2: 45,210,600–45,245,429, reverse strandEXOC3L2CKM: 45,306,411–45,323,372, reverse strandCKMKLC3: 45,333,434–45,351,537, forward strandKLC3ERCC2: 45,349,773–45,370,918, reverse strandERCC2PPP1R13L: 45,379,634–45,406,367, reverse strandPPP1R13LPOLR1G: 45,406,644–45,410,737, forward strandPOLR1GERCC1: 45,407,333–45,479,055, reverse strandERCC1Diagram of APOE: 4 exons on the forward strand of chromosome 19Exon 2: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 4: 11 known disease-causing sitesExon 1: 44,905,796–44,905,841, 46 basesExon 2: 44,906,602–44,906,667, 66 basesExon 3: 44,907,760–44,907,952, 193 basesExon 4: 44,908,533–44,909,393, 861 bases12345′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.2 kb of the gene's 3.6 kb; 954 of those bases code for the protein.

How a genome test reads APOE

13

positions in APOE where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3.6 kb of APOE, introns included, not only the 1.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). APOE gene: apolipoprotein E. Retrieved 17 October 2026, from https://dantelabs.com/genes/apoe

Vancouver

Dante Labs. APOE gene: apolipoprotein E [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/apoe

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