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Gene

ACP5

acid phosphatase 5, tartrate resistant

Summary

Cytogenetic location
19p13.2
Coordinates
Chromosome 19: 11,574,660–11,577,645 (GRCh38)
Exons
5 exons across 3 kb
Protein
325 amino acids
Inheritance
Autosomal dominant Autosomal recessive
Also known as
TRAP, HPAP, TRAcP
MANE Select transcript
ENST00000648477.1NM_001611.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Rare Monogenic Autoinflammatory Diseases

    • PTPN2-related autoinflammation and autoimmunityAutosomal dominant

      Early-onset inflammatory and autoimmune disease, including colitis and arthritis, caused by variants in PTPN2.

      • 3 GenCC submitters rate it definitive or strong

  • Type I Interferonopathies

    • Spondyloenchondrodysplasia with immune dysregulationAutosomal recessive

      A skeletal dysplasia with autoimmunity, such as lupus or low platelets, caused by variants in ACP5.

      • 3 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.
Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How ACP5 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 19, with a bracket where ACP5 sits. ACP5 and 38 genes near it on chromosome 19, from 11,076,153 to 12,076,152.Chromosome 1919p13.2p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4311.2 Mb11.4 Mb11.6 Mb11.8 Mb12 MbSMARCA4: 10,960,824–11,079,426, forward strandSMARCA4LDLR: 11,089,418–11,133,830, forward strandLDLRSPC24: 11,131,419–11,155,815, reverse strandSPC24KANK2: 11,164,264–11,197,945, reverse strandKANK2DOCK6: 11,199,295–11,262,533, reverse strandDOCK6ANGPTL8: 11,237,502–11,245,478, forward strandANGPTL8TSPAN16: 11,296,139–11,326,996, forward strandRAB3D: 11,322,047–11,346,433, reverse strandTMEM205: 11,342,775–11,346,534, reverse strandCCDC159: 11,344,684–11,354,948, forward strandCCDC159PLPPR2: 11,355,386–11,365,698, forward strandPLPPR2SWSAP1: 11,374,658–11,379,194, forward strandEPOR: 11,377,207–11,384,343, reverse strandEPORRGL3: 11,384,341–11,419,372, reverse strandRGL3ODAD3: 11,420,604–11,435,782, reverse strandODAD3PRKCSH: 11,422,369–11,450,969, forward strandPRKCSHELAVL3: 11,451,326–11,481,051, reverse strandELAVL3: 11,466,240–11,505,698, reverse strandZNF653: 11,483,134–11,505,839, reverse strandZNF653ECSIT: 11,505,916–11,540,137, reverse strandECSITCNN1: 11,538,767–11,550,323, forward strandCNN1ELOF1: 11,551,147–11,559,325, reverse strandELOF1ZNF627: 11,559,374–11,622,582, forward strandZNF627ACP5: 11,574,660–11,577,645, reverse strandACP5ZNF823: 11,721,263–11,739,027, reverse strandZNF823ZNF441: 11,767,000–11,784,078, forward strandZNF441ZNF491: 11,797,642–11,809,622, forward strandZNF491ZNF440: 11,814,257–11,835,567, forward strandZNF440ZNF439: 11,848,716–11,883,750, forward strandZNF439ZNF69: 11,887,759–11,919,844, forward strandZNF69ZNF700: 11,925,064–11,950,774, forward strandZNF700: 11,925,075–11,979,290, forward strandZNF763: 11,965,030–11,983,128, forward strandZNF763: 11,987,641–12,078,106, forward strandZNF433: 11,988,498–12,035,741, reverse strandZNF433: 12,017,888–12,052,967, reverse strandZNF878: 12,040,992–12,052,983, reverse strandZNF878ZNF844: 12,064,690–12,081,565, forward strand: 12,075,327–12,113,325, forward strandDiagram of ACP5: 5 exons on the reverse strand of chromosome 19Exon 5: 4 known disease-causing sitesExon 4: 13 known disease-causing sitesExon 3: 6 known disease-causing sitesExon 2: 7 known disease-causing sitesExon 5: 11,574,660–11,575,252, 593 basesExon 4: 11,576,243–11,576,588, 346 basesExon 3: 11,576,716–11,576,843, 128 basesExon 2: 11,577,057–11,577,317, 261 basesExon 1: 11,577,593–11,577,645, 53 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.4 kb of the gene's 3 kb; 978 of those bases code for the protein.

How a genome test reads ACP5

31

positions in ACP5 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3 kb of ACP5, introns included, not only the 1.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ACP5 gene: acid phosphatase 5, tartrate resistant. Retrieved 16 October 2026, from https://dantelabs.com/genes/acp5

Vancouver

Dante Labs. ACP5 gene: acid phosphatase 5, tartrate resistant [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/acp5

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