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Trait

Nephrotic range proteinuria

Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children.

HPO HP:0012593

Summary

Body system
Laboratory abnormalityAbnormality of the genitourinary system

6 genes linked to Nephrotic range proteinuria

Changes in these genes cause rare conditions in which Nephrotic range proteinuria is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
CD81CD81 moleculeAlwaysIn 1 condition
NOS1APnitric oxide synthase 1 adaptor proteinAlwaysIn 1 condition
OAS22'-5'-oligoadenylate synthetase 2AlwaysIn 1 condition
DGKEdiacylglycerol kinase epsilonOften (30–79%)In 1 condition
SMARCAL1SNF2 related chromatin remodeling annealing helicase 1Often (30–79%)In 1 condition
DDOSTdolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunitRarely (1–4%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

High urine protein levels

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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