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Gene

FN1

fibronectin 1

Summary

Cytogenetic location
2q35
Coordinates
Chromosome 2: 215,360,865–215,436,068 (GRCh38)
Exons
46 exons across 75.2 kb
Protein
2,477 amino acids
Inheritance
Autosomal dominant
Also known as
MSF, CIG, LETS, GFND2, FINC, lnc-ABCA12-8
MANE Select transcript
ENST00000354785.11NM_212482.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Epiphyseal and Spondyloepiphyseal Dysplasias

    • Spondylometaphyseal dysplasia, corner fracture typeAutosomal dominant

      Short stature, spinal changes and corner-fracture-like bone changes caused by FN1 variants.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How FN1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where FN1 sits. FN1 and 2 genes near it on chromosome 2, from 214,898,467 to 215,898,466.Chromosome 22q35p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3215 Mb215.2 Mb215.4 Mb215.6 Mb215.8 MbABCA12: 214,931,542–215,138,626, reverse strandABCA12ATIC: 215,311,956–215,352,251, forward strandATICFN1: 215,360,865–215,436,068, reverse strandFN1Diagram of FN1: 46 exons on the reverse strand of chromosome 2Exon 36: 1 known disease-causing siteExon 20: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 6: 3 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 3: 1 known disease-causing siteExon 2: 2 known disease-causing sitesExon 46: 215,360,865–215,361,626, 762 basesExon 45: 215,361,969–215,362,079, 111 basesExon 44: 215,364,879–215,364,985, 107 basesExon 43: 215,365,505–215,365,630, 126 basesExon 42: 215,367,863–215,368,027, 165 basesExon 41: 215,370,294–215,370,432, 139 basesExon 40: 215,371,909–215,372,375, 467 basesExon 39: 215,373,322–215,373,411, 90 basesExon 38: 215,375,214–215,375,393, 180 basesExon 37: 215,375,629–215,375,718, 90 basesExon 36: 215,376,498–215,376,674, 177 basesExon 35: 215,378,175–215,378,262, 88 basesExon 34: 215,379,130–215,379,317, 188 basesExon 33: 215,380,811–215,381,080, 270 basesExon 32: 215,382,212–215,382,325, 114 basesExon 31: 215,383,328–215,383,483, 156 basesExon 30: 215,384,020–215,384,184, 165 basesExon 29: 215,384,860–215,384,976, 117 basesExon 28: 215,386,689–215,386,958, 270 basesExon 27: 215,388,212–215,388,301, 90 basesExon 26: 215,391,632–215,391,814, 183 basesExon 25: 215,392,931–215,393,203, 273 basesExon 24: 215,394,528–215,394,719, 192 basesExon 23: 215,397,137–215,397,223, 87 basesExon 22: 215,397,680–215,397,848, 169 basesExon 21: 215,399,257–215,399,351, 95 basesExon 20: 215,404,389–215,404,655, 267 basesExon 19: 215,406,238–215,406,510, 273 basesExon 18: 215,407,127–215,407,321, 195 basesExon 17: 215,408,108–215,408,197, 90 basesExon 16: 215,408,298–215,408,426, 129 basesExon 15: 215,409,563–215,409,739, 177 basesExon 14: 215,409,934–215,410,114, 181 basesExon 13: 215,414,837–215,414,958, 122 basesExon 12: 215,419,242–215,419,385, 144 basesExon 11: 215,420,673–215,420,801, 129 basesExon 10: 215,422,091–215,422,243, 153 basesExon 9: 215,423,350–215,423,526, 177 basesExon 8: 215,424,146–215,424,325, 180 basesExon 7: 215,425,094–215,425,285, 192 basesExon 6: 215,428,180–215,428,338, 159 basesExon 5: 215,430,715–215,430,852, 138 basesExon 4: 215,431,833–215,431,964, 132 basesExon 3: 215,433,324–215,433,461, 138 basesExon 2: 215,434,696–215,434,824, 129 basesExon 1: 215,435,655–215,436,068, 414 bases464030201015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8.4 kb of the gene's 75.2 kb; 7,434 of those bases code for the protein.

How a genome test reads FN1

16

positions in FN1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 75.2 kb of FN1, introns included, not only the 8.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FN1 gene: fibronectin 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/fn1

Vancouver

Dante Labs. FN1 gene: fibronectin 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fn1

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