Gene
TNFAIP3
TNF alpha induced protein 3
- HGNC 11896(opens in a new tab)
- Ensembl gene ENSG00000118503(opens in a new tab)
- NCBI Gene 7128(opens in a new tab)
Summary
- Cytogenetic location
- 6q23.3
- Coordinates
- Chromosome 6: 137,867,259–137,883,312 (GRCh38)
- Exons
- 9 exons across 16.1 kb
- Protein
- 790 amino acids
- Inheritance
- Autosomal dominant
- Also known as
- A20, OTUD7C
- MANE Select transcript
- ENST00000612899.5NM_001270508.2
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Rare Monogenic Autoinflammatory Diseases
- Haploinsufficiency of A20 (HA20)Autosomal dominant
A Behcet-like disease with mouth and genital ulcers, fevers and autoimmunity, caused by variants in TNFAIP3.
- 2 GenCC submitters rate it definitive or strong
Inheritance
- Autosomal dominant
- One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.
How TNFAIP3 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.7 kb of the gene's 16.1 kb; 2,373 of those bases code for the protein.
How a genome test reads TNFAIP3
20
positions in TNFAIP3 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 16.1 kb of TNFAIP3, introns included, not only the 4.7 kb of exons.
Traits linked to TNFAIP3
The Human Phenotype Ontology lists these as features of the rare conditions TNFAIP3 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the immune system
- Antinuclear antibody positivity
- Anti-complement component C1q antibody positivity
- Anti-ribosome Po antibody positivity
- Anti-titin antibody positivity
- Antineutrophil antibody positivity
- Decreased circulating complement C3 concentration
- Decreased circulating complement C4 concentration
- Malar rash
Show 11 more traits
- Skin rash
- Anti-dsDNA antibody positivity
- Anti-La/SS-B antibody positivity
- Anti-nucleoporin 62 antibody positivity
- Anti-phosphatidic acid antibody positivity
- Anti-Ro52/TRIM21 antibody positivity
- Anti-Sm antibody positivity
- Anti-U1 ribonucleoprotein antibody positivity
- Discoid lupus rash
- Lupus anticoagulant
- Serositis
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). TNFAIP3 gene: TNF alpha induced protein 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/tnfaip3
Dante Labs. TNFAIP3 gene: TNF alpha induced protein 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tnfaip3
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