Skip to content
Use your HSA or FSA funds

Gene

SLC2A2

solute carrier family 2 member 2

Summary

Cytogenetic location
3q26.2
Coordinates
Chromosome 3: 170,996,347–171,026,720 (GRCh38)
Exons
11 exons across 30.4 kb
Protein
524 amino acids
Inheritance
Autosomal recessive
Also known as
GLUT-2
Previous symbols
GLUT2
MANE Select transcript
ENST00000314251.8NM_000340.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Diabetes Mellitus

    • A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Teplizumab (Tzield) for stage 2 presymptomatic T1D (FDA approved 2022); insulin replacement at clinical T1D onset; TrialNet autoantibody screening for high-risk relatives; closed-loop insulin delivery systems

  • Glycogen Storage Disease

    • Fanconi-Bickel SyndromeAutosomal recessive

      Caused by variants in SLC2A2 (GLUT2), which cause liver glycogen storage, kidney tubule dysfunction, low blood sugar when fasting and poor growth.

      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing allows frequent feeds, slow-release starch and replacement of minerals lost through the kidneys.

  • Neonatal Diabetes Mellitus

    • Diabetes diagnosed in the first months of life, either permanent or transient, caused by single-gene defects in insulin production or secretion.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Most people with KCNJ11 or ABCC8 neonatal diabetes can switch from insulin injections to sulfonylurea tablets, often with better glucose control.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How SLC2A2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where SLC2A2 sits. SLC2A2 and 5 genes near it on chromosome 3, from 170,511,534 to 171,511,533.Chromosome 33q26.2p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29170.6 Mb170.8 Mb171 Mb171.2 Mb171.4 Mb: 170,418,868–170,860,380, forward strandSLC7A14: 170,459,548–170,586,149, reverse strandSLC7A14RPL22L1: 170,864,875–170,870,475, reverse strandRPL22L1EIF5A2: 170,888,418–170,908,644, reverse strandEIF5A2SLC2A2: 170,996,347–171,026,720, reverse strandSLC2A2TNIK: 171,058,414–171,460,473, reverse strandTNIKDiagram of SLC2A2: 11 exons on the reverse strand of chromosome 3Exon 11: 1 known disease-causing siteExon 10: 7 known disease-causing sitesExon 9: 1 known disease-causing siteExon 8: 3 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 6: 5 known disease-causing sitesExon 5: 1 known disease-causing siteExon 4: 5 known disease-causing sitesExon 3: 8 known disease-causing sitesExon 2: 1 known disease-causing siteExon 1: 2 known disease-causing sitesExon 11: 170,996,347–170,998,103, 1,757 basesExon 10: 170,998,193–170,998,396, 204 basesExon 9: 170,999,065–170,999,166, 102 basesExon 8: 171,002,576–171,002,680, 105 basesExon 7: 171,005,285–171,005,472, 188 basesExon 6: 171,005,943–171,006,105, 163 basesExon 5: 171,007,148–171,007,263, 116 basesExon 4: 171,009,958–171,010,082, 125 basesExon 3: 171,014,469–171,014,731, 263 basesExon 2: 171,018,531–171,018,623, 93 basesExon 1: 171,026,656–171,026,720, 65 bases11109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.2 kb of the gene's 30.4 kb; 1,575 of those bases code for the protein.

How a genome test reads SLC2A2

44

positions in SLC2A2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 30.4 kb of SLC2A2, introns included, not only the 3.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SLC2A2 gene: solute carrier family 2 member 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/slc2a2

Vancouver

Dante Labs. SLC2A2 gene: solute carrier family 2 member 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/slc2a2

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test