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Gene

SLC22A12

solute carrier family 22 member 12

Summary

Cytogenetic location
11q13.1
Coordinates
Chromosome 11: 64,591,220–64,602,344 (GRCh38)
Exons
10 exons across 11.1 kb
Protein
553 amino acids
Inheritance
Autosomal recessive
Also known as
OAT4L, RST, URAT1, hURAT1, UAT
MANE Select transcript
ENST00000377574.6NM_144585.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Renal Hypouricemia

    • Hereditary Renal HypouricemiaAutosomal recessive

      A recessive disorder of uric acid reabsorption caused by variants in SLC22A12 or SLC2A9, associated with exercise-induced acute kidney injury and uric acid stones.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing supports staying well hydrated and avoiding extreme anaerobic exercise to reduce the risk of kidney injury.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How SLC22A12 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where SLC22A12 sits. SLC22A12 and 44 genes near it on chromosome 11, from 64,096,782 to 65,096,781.Chromosome 1111q13.1p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2564.2 Mb64.4 Mb64.6 Mb64.8 Mb65 MbMACROD1: 63,998,553–64,166,501, reverse strandMACROD1FLRT1: 64,035,757–64,119,403, forward strandFLRT1STIP1: 64,185,272–64,204,549, forward strandSTIP1FERMT3: 64,205,926–64,223,896, forward strandTRPT1: 64,223,799–64,226,823, reverse strandNUDT22: 64,225,941–64,230,686, forward strandDNAJC4: 64,230,158–64,234,286, forward strandVEGFB: 64,234,406–64,239,264, forward strandFKBP2: 64,241,003–64,244,583, forward strandFKBP2: 64,241,095–64,244,583, forward strandPPP1R14B: 64,244,478–64,246,956, reverse strandPLCB3: 64,251,498–64,269,424, forward strandPLCB3BAD: 64,269,828–64,291,946, reverse strandBADGPR137: 64,270,062–64,290,690, forward strandKCNK4: 64,291,302–64,300,031, forward strandCATSPERZ: 64,300,338–64,304,770, forward strandESRRA: 64,305,080–64,317,859, forward strandTRMT112: 64,316,460–64,318,086, reverse strandTRMT112PRDX5: 64,317,977–64,321,827, forward strandPRDX5CCDC88B: 64,340,197–64,357,534, forward strandCCDC88BRPS6KA4: 64,359,134–64,372,215, forward strandRPS6KA4SLC22A11: 64,555,632–64,572,875, forward strandSLC22A11SLC22A12: 64,591,220–64,602,344, forward strandSLC22A12NRXN2: 64,606,174–64,723,202, reverse strandNRXN2RASGRP2: 64,726,905–64,745,456, reverse strandRASGRP2PYGM: 64,746,389–64,759,990, reverse strandPYGMSF1: 64,764,605–64,778,802, reverse strandSF1MAP4K2: 64,784,918–64,803,245, reverse strandMAP4K2MEN1: 64,803,500–64,811,294, reverse strandMEN1CDC42BPG: 64,823,051–64,844,735, reverse strandCDC42BPGEHD1: 64,851,642–64,888,372, reverse strandEHD1ATG2A: 64,894,531–64,917,249, reverse strandATG2APPP2R5B: 64,917,553–64,934,480, forward strandPPP2R5BGPHA2: 64,934,471–64,935,894, reverse strandGPHA2MAJIN: 64,937,517–64,972,113, reverse strandMAJINBATF2: 64,987,945–64,997,018, reverse strandBATF2ARL2: 65,013,735–65,024,328, forward strandARL2ARL2-SNX15: 65,014,182–65,040,570, forward strandARL2-SNX15SNX15: 65,027,404–65,040,578, forward strandSNX15SAC3D1: 65,040,897–65,047,320, forward strandNAALADL1: 65,044,818–65,058,558, reverse strandCDCA5: 65,066,299–65,084,164, reverse strandZFPL1: 65,084,210–65,088,409, forward strandZFPL1CATSPERH: 65,084,974–65,089,375, reverse strandVPS51: 65,089,324–65,111,862, forward strandVPS51Diagram of SLC22A12: 10 exons on the forward strand of chromosome 11Exon 1: 2 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 6: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 9: 1 known disease-causing siteExon 1: 64,591,220–64,591,958, 739 basesExon 2: 64,592,779–64,592,882, 104 basesExon 3: 64,593,405–64,593,559, 155 basesExon 4: 64,593,635–64,593,803, 169 basesExon 5: 64,598,516–64,598,639, 124 basesExon 6: 64,598,808–64,598,923, 116 basesExon 7: 64,599,676–64,599,890, 215 basesExon 8: 64,600,367–64,600,475, 109 basesExon 9: 64,600,735–64,600,938, 204 basesExon 10: 64,601,488–64,602,344, 857 bases123456789105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.8 kb of the gene's 11.1 kb; 1,662 of those bases code for the protein.

How a genome test reads SLC22A12

13

positions in SLC22A12 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 11.1 kb of SLC22A12, introns included, not only the 2.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SLC22A12 gene: solute carrier family 22 member 12. Retrieved 17 October 2026, from https://dantelabs.com/genes/slc22a12

Vancouver

Dante Labs. SLC22A12 gene: solute carrier family 22 member 12 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/slc22a12

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