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Gene

COX15

cytochrome c oxidase assembly factor COX15

Summary

Cytogenetic location
10q24.2
Coordinates
Chromosome 10: 99,710,868–99,732,127 (GRCh38)
Exons
9 exons across 21.3 kb
Protein
410 amino acids
Also known as
CEMCOX2
MANE Select transcript
ENST00000016171.6NM_078470.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Primary Mitochondrial Disease

      • Mitochondrial Respiratory Chain Complex Deficiency

        One of 61 genes linked to it

        Isolated deficiencies of complex I, II, III, IV or V, caused by variants in nuclear or mitochondrial genes, which can affect the brain, muscles, heart, liver and other energy-demanding organs.

        • 2 GenCC submitters rate it definitive or strong
        What knowing changes

        Knowing can end a diagnostic search and guide surveillance of affected organs and avoidance of drugs toxic to mitochondria.

    How COX15 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 10, with a bracket where COX15 sits. COX15 and 13 genes near it on chromosome 10, from 99,221,498 to 100,221,497.Chromosome 1010q24.2p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.399.4 Mb99.6 Mb99.8 Mb100 Mb100.2 MbHPSE2: 98,457,077–99,235,878, reverse strandHPSE2CNNM1: 99,329,030–99,394,330, forward strandCNNM1GOT1: 99,396,869–99,431,465, reverse strandGOT1NKX2-3: 99,532,928–99,536,524, forward strandNKX2-3SLC25A28: 99,610,509–99,622,793, reverse strandSLC25A28: 99,651,595–99,732,112, reverse strandENTPD7: 99,659,415–99,712,489, forward strandENTPD7CUTC: 99,702,558–99,758,005, forward strandCUTCCOX15: 99,710,868–99,732,127, reverse strandCOX15ABCC2: 99,782,640–99,853,670, forward strandABCC2DNMBP: 99,875,576–100,010,049, reverse strandDNMBPCPN1: 100,041,105–100,081,907, reverse strandCPN1ERLIN1: 100,150,094–100,186,062, reverse strandERLIN1CHUK: 100,188,299–100,229,611, reverse strandCHUKDiagram of COX15: 9 exons on the reverse strand of chromosome 10Exon 8: 2 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 5: 4 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 2: 1 known disease-causing siteExon 9: 99,710,868–99,714,718, 3,851 basesExon 8: 99,716,348–99,716,461, 114 basesExon 7: 99,718,346–99,718,500, 155 basesExon 6: 99,720,987–99,721,068, 82 basesExon 5: 99,723,956–99,724,123, 168 basesExon 4: 99,726,968–99,727,154, 187 basesExon 3: 99,727,441–99,727,563, 123 basesExon 2: 99,729,553–99,729,734, 182 basesExon 1: 99,731,960–99,732,127, 168 bases9876543215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 5 kb of the gene's 21.3 kb; 1,233 of those bases code for the protein.

    How a genome test reads COX15

    20

    positions in COX15 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 21.3 kb of COX15, introns included, not only the 5 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). COX15 gene: cytochrome c oxidase assembly factor COX15. Retrieved 16 October 2026, from https://dantelabs.com/genes/cox15

    Vancouver

    Dante Labs. COX15 gene: cytochrome c oxidase assembly factor COX15 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cox15

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